The Pulse of Cardiology

O’Rourke, Michael; Hayward, Christopher

doi:10.1016/j.jacc.2009.04.065

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…The level of central BP is influenced by several variables, including arterial stiffness and pressure wave reflection. However, the predominant role is a matter of debate (37). Exemplary findings from a twin study suggested that the increase in central BP was mainly associated with increased pulse wave reflection due to arterial dimensions or peripheral large artery tone, rather than arterial stiffness (38).…”

Section: Discussionmentioning

confidence: 99%

Vascular and Renal Hemodynamic Changes after Renal Denervation

Ott¹,

Janka

Schmid

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Renal denervation (RDN) has been shown to be effective in reducing BP in treatmentresistant hypertension. Measurement of the renal and sympathetic activity revealed a decrease in sympathetic drive to the kidney and small resistance vessels after RDN. However, the consequences on renal perfusion and renal vascular resistance (RVR), as well as central hemodynamics, are unknown.Design, setting, participants, & measurements Nineteen patients with treatment-resistant hypertension (office BP$140/90 mmHg, despite at least three antihypertensive drugs [including a diuretic], and diagnosis confirmed by 24-hour ambulatory BP monitoring) underwent RDN between January and October 2011. Renal perfusion and RVR were noninvasively assessed by magnetic resonance imaging with arterial spin labeling, and renal function was assessed by estimating GFR before (day 21), after (day +1), and again after 3 months of RDN. Central hemodynamics was assessed using pulse wave analysis at day 21 and after 6 months of RDN.

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Section: Discussionmentioning

confidence: 99%

Vascular and Renal Hemodynamic Changes after Renal Denervation

Ott¹,

Janka

Schmid

et al. 2013

Clinical Journal of the American Society of Nephrology

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“…Approaches providing central pressures and, in addition, waveform characteristics may give added value. 10 In conclusion, the NPMA method, applied on regular cuffs, is a next attempt to get closer to the heart of the matter, as far as systolic blood pressure is concerned. As with all other methods, clinical studies with cardiovascular end points (clinical validation) will allow the definite assessment of its utility.…”

Section: Hypertensionmentioning

confidence: 99%

Moving On—On Average in the Right Direction?

Weber

Wassertheurer²

2014

Hypertension

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Heart rate reduction decreases central blood pressure in sick sinus syndrome patients with a permanent cardiac pacemaker

et al. 2018

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Increased resting heart rate (HR) contributes to higher cardiovascular mortality and morbidity in the healthy as well as in people with cardiovascular diseases, possibly due to elevated blood pressure (BP) among other mechanisms. Data on the relationship between HR and central (aortic) BP remains controversial, however, and concerning β-blockers, it has been proposed that pharmacological HR lowering is associated with augmentation of central BP. We aimed to study the role of pharmacologically unaffected HR on central BP indices in sick sinus syndrome patients with a permanent cardiac pacemaker in the HR range from 40 to 90 bpm. We included 27 subjects (mean age 65.8 ± 9.5 years, 12 men) with a dual-chamber pacemaker implanted due to sick sinus syndrome. We determined central hemodynamic indices noninvasively during an atrial pacing mode at low (40 bpm), middle (60 bpm), and high (90 bpm) HR levels with an oscillometric cuff-based device (Sphygmocor XCEL). There was no difference in central systolic BP at the middle versus the high HR level (mean 121.2 ± 13.0 and 121.2 ± 12.1 mmHg, respectively, P = 0.9), but at the low HR level, it was significantly lower than at the middle HR level (mean 117.2 ± 13.1 and 121.2 ± 13.0 mmHg, P < 0.01). Our acute study provides evidence to suggest that at a HR of <60 bpm, sick sinus syndrome patients may have a lower central BP than at a higher HR, despite the proposed augmenting effects of low HR on central BP.

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The Pulse of Cardiology

Cited by 5 publications

References 43 publications

Vascular and Renal Hemodynamic Changes after Renal Denervation

Vascular and Renal Hemodynamic Changes after Renal Denervation

Moving On—On Average in the Right Direction?

Heart rate reduction decreases central blood pressure in sick sinus syndrome patients with a permanent cardiac pacemaker

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