The Pulmonary Response to Fibrous Dusts of Diverse Compositions

Gross, Paul; deTrevïlle, Robert T. P.; Cralley, Lewis J.; Granquist, W. T.; Pundsack, Fred L.

doi:10.1080/0002889708506221

Cited by 35 publications

(8 citation statements)

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“…However, our results cannot be entirely explained on this basis, since the effect of particulates alone tends to be manifested by macrophage exudation into the air spaces. and sometimes by the evolution of fibrosis (27). The morphology of the histopathologic lung changes in our exposed rabbits was indicative of an inflammatory response in both the pulmonary airways and the interstitium.…”

Section: Additional Studiesmentioning

confidence: 84%

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Animal model of grain worker's lung.

Stepner¹,

Broder²,

Baumal³

1986

Environ Health Perspect

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We examined the light microscopic changes in the lungs of rabbits exposed to grain dust for variable periods of time, to determine whether an animal model of grain worker's lung could be developed. Experimental animals were exposed to grain dust at a concentration of 20 mg/m3 for 7 hr/day, 5 days/week, for up to 6 months. The lungs of these rabbits demonstrated a granulomatous interstitial pneumonitis associated with exudation of mononuclear cells into the alveoli and conducting airways. These changes appeared within 5 days of the onset of exposure and reached a peak at 3 weeks but were sustained through the longest exposure interval. No abnormalities were observed in the lungs of control rabbits. These results show three points of consistency with those obtained in epidemiologic studies of grain elevator workers. First, the rapid appearance of the experimental changes suggests that the mechanism of tissue injury may not be immunologic. Second, the occurrence of the histopathologic alterations in the interstitium, alveoli, and airways corresponds with the combined restrictive and obstructive ventilatory defect described in the human epidemiologic studies. Third, the absence of lung fibrosis in rabbits exposed to dust for 6 months suggests that the pneumonitis is reversible. Thus this experimental model shows promise of helping to clarify the nature and mechanism of the adverse pulmonary effects of grain dust.

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Section: Additional Studiesmentioning

confidence: 84%

“…The average monthly temperature in the chambers ranged from 16 to 24°C, with a daily minimum of 10 and maximum of 27 (Table 1). The average monthly total dust concentration was similar in both chambers and approximated 20 mg/m3.…”

Section: Chamber Conditionsmentioning

confidence: 99%

Animal model of grain worker's lung.

Stepner¹,

Broder²,

Baumal³

1986

Environ Health Perspect

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“…8 Such lesions were found in the rat lungs four days after the intratracheal injections. However, animals killed after one year or later failed to show .…”

Section: Arch Environ Health-vol 20 June 1970mentioning

confidence: 95%

The Pulmonary Reaction to High Concentrations of Fibrous Glass Dust

Gross

Kaschak

Tolker

et al. 1970

Archives of Environmental Health: An International Journal

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“…The effects of GW have been tested by inhalation on three rodent species: rat, hamster, and guinea pig (9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The results reported by Drew et al (14) are not included here because the animals in that study were exposed for 10 weeks and sacrifice'd within 2 months after exposure, which did not permit the study of fibrosis and cancer.…”

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

“…A third report was not taken into consideration because of the high rate of deaths at 12 months (9). One lung carcinoma out of 20 hamsters inoculated with 10 mg (5 inoculations of 2 mg each) GF with a mean diameter of 0.65 pm (0% <0.2 pm) was detected in one experiment (19).…”

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

Review of Animal/In Vitro Data on Biological Effects of Man-Made Fibers

Achard¹,

Jaurand²

1994

Environmental Health Perspectives

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This paper reviews the investigations with man-made fibers (MMF). Insulation wools: glasswool (GW), rockwool (RW), slagwool (SW), glass microfibers (GMF), glass filaments (GFiI), and refractory ceramic fibers (RCF) have been used in experimental animals and in in vitro cell systems. A large heterogeneous number of fibers, methods of fiber preparation, size selection, aerosolization, fiber size, and fiber burden measurement were noted, rendering difficult a comparison between results. By inhalation, RCF and asbestos used as positive controls produced a significant tumor increase. In some studies, a low tumor yield was found after inhalation of insulation wools; when all inhalation data were gathered, a significant tumor increase was found with GW. However, it is difficult to draw definitive conclusions on the potential of other fiber types because, in addition to the different compositions of the fibers, differences in fiber number and sizes existed, especially in comparison with asbestos. Moreover, experiments using inoculation, especially by the intraperitoneal route revealed a carcinogenic potential of all fibers types but GFiI and SW. In these two groups a small number of animals has been investigated and the fiber characteristics were sometimes irrelevant. So far, a relationship between the carcinogenic potency and fiber dimensions has been established. Other fiber parameters may be of importance (surface chemistry, biopersistence, fiber structure, for example) but further investigations are necessary to determine the correlations between these parameters and tumor incidence. In vitro experiments have emphasized the fiber characteristics identified in vivo as playing a role in the carcinogenic potency and should be developed as a better approach of the mechanistic effects of MMF. -Environ Health Perspect 1 02 (Suppl 2:47-63 (1994).

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The Pulmonary Response to Fibrous Dusts of Diverse Compositions

Cited by 35 publications

References 0 publications

Animal model of grain worker's lung.

Animal model of grain worker's lung.

The Pulmonary Reaction to High Concentrations of Fibrous Glass Dust

Review of Animal/In Vitro Data on Biological Effects of Man-Made Fibers

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