The Pulmonary Reaction to High Concentrations of Fibrous Glass Dust

Gross, Paul; Kaschak, Marianne; Tolker, Ethel B.; Babyak, Mary Ann; Treville, Robert T. P. de

doi:10.1080/00039896.1970.10665646

Cited by 39 publications

(12 citation statements)

References 5 publications

(2 reference statements)

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“…The effects of GW have been tested by inhalation on three rodent species: rat, hamster, and guinea pig (9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The results reported by Drew et al (14) are not included here because the animals in that study were exposed for 10 weeks and sacrifice'd within 2 months after exposure, which did not permit the study of fibrosis and cancer.…”

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

“…In hamsters none of the three studies (10,11,16) showed tumor production after inhalation; however, tumors also were not found in positive control hamsters exposed to either 300 mg/m3 amosite (7 hamsters) or 7 mg/m3 crocidolite (70 hamsters) ( Table 2). Only one study has been performed with guinea pig (11); few animals were exposed, two adenomas were detected in eight GF-exposed guinea pigs while no .r tumors were found in unexposed controls or in amosite-exposed animals.…”

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

“…However, contradictory results were obtained by Drew et al (14), who observed an unspecific monocytic leukemia in rats after chronic exposure to GF. In the preliminary report by Gross et al (10), heavily collagenized stroma was observed after a 12-month exposure.…”

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

“…The results reported by Drew et al (14) are not included here because the animals in that study were exposed for 10 weeks and sacrifice'd within 2 months after exposure, which did not permit the study of fibrosis and cancer. Similarly, the pulmonary reactions described in the preliminary report of Gross et al (10) seem limited to a 12-month exposure with rats and only data with hamsters can been taken into consideration. Moreover, the study by Moorman et al (17) should be interpreted with caution because it lacks information on survival times.…”

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

“…Intratracheal instillations with GW or GF have been carried out in two experiments using a total of 83 hamsters (10,19). A third report was not taken into consideration because of the high rate of deaths at 12 months (9).…”

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

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Review of Animal/In Vitro Data on Biological Effects of Man-Made Fibers

Achard¹,

Jaurand²

1994

Environmental Health Perspectives

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This paper reviews the investigations with man-made fibers (MMF). Insulation wools: glasswool (GW), rockwool (RW), slagwool (SW), glass microfibers (GMF), glass filaments (GFiI), and refractory ceramic fibers (RCF) have been used in experimental animals and in in vitro cell systems. A large heterogeneous number of fibers, methods of fiber preparation, size selection, aerosolization, fiber size, and fiber burden measurement were noted, rendering difficult a comparison between results. By inhalation, RCF and asbestos used as positive controls produced a significant tumor increase. In some studies, a low tumor yield was found after inhalation of insulation wools; when all inhalation data were gathered, a significant tumor increase was found with GW. However, it is difficult to draw definitive conclusions on the potential of other fiber types because, in addition to the different compositions of the fibers, differences in fiber number and sizes existed, especially in comparison with asbestos. Moreover, experiments using inoculation, especially by the intraperitoneal route revealed a carcinogenic potential of all fibers types but GFiI and SW. In these two groups a small number of animals has been investigated and the fiber characteristics were sometimes irrelevant. So far, a relationship between the carcinogenic potency and fiber dimensions has been established. Other fiber parameters may be of importance (surface chemistry, biopersistence, fiber structure, for example) but further investigations are necessary to determine the correlations between these parameters and tumor incidence. In vitro experiments have emphasized the fiber characteristics identified in vivo as playing a role in the carcinogenic potency and should be developed as a better approach of the mechanistic effects of MMF. -Environ Health Perspect 1 02 (Suppl 2:47-63 (1994).

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Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

Section: Animal Experiments With Insulation Wools Experiments With Glmentioning

confidence: 99%

See 3 more Smart Citations

Review of Animal/In Vitro Data on Biological Effects of Man-Made Fibers

Achard¹,

Jaurand²

1994

Environmental Health Perspectives

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Faserstäube [MAK Value Documentation in German language, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Pneumoconiosis associated with exposure to glass and abrasive particles

Brody

Miller

Langer

1984

American J Industrial Med

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A patient with a history of decorating glass fixtures by means of abrasive etching presented with a disease characterized by diffuse infiltrates on chest roentgenogram and restriction and diffusion impairment on pulmonary function testing. Mineralogic analysis of biopsied pulmonary lesions showed particles consistent in composition to the glasses etched and abrasives used. The former particles were noncrystalline. Silicate mineral phases were identified as well, these displaying crystalline properties. Previous studies of workers exposed to abrasives, ie, silicon carbide and emery (as a form of corundum) suggest slight pneumoconiotic risk exists; this is also the case for workers exposed to forms of industrially made glass. The question is raised as to whether there exists, in this present case, an etiological association between exposure to respirable glassy particles and the development of pulmonary scarring.

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The Pulmonary Reaction to High Concentrations of Fibrous Glass Dust

Cited by 39 publications

References 5 publications

Review of Animal/In Vitro Data on Biological Effects of Man-Made Fibers

Review of Animal/In Vitro Data on Biological Effects of Man-Made Fibers

Faserstäube [MAK Value Documentation in German language, 1993]

Pneumoconiosis associated with exposure to glass and abrasive particles

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