The psychotropic drug olanzapine (Zyprexa®) increases the area of acid glycerophospholipid monolayers

Olanzapine interaction with dipalmitoyl phosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoyl phosphatidylserine (POPS) bilayer: A 13C and 31P solid-state NMR study

“…4, right column and top row). Furthermore, OLZ interaction with phospholipid monolayers has recently been investigated and found to be substantial, in agreement with the findings of this NMR study on bilayers [52].…”

Interactions of bioactive molecules & nanomaterials with Langmuir monolayers as cell membrane models

“…Also, the effect was more pronounced for acidic (brain PS) than for zwitterionic (DPPC) phospholipids. These results are consistent with data for chlorpromazine and trifluoroperazine [229,230]. However, the atypical neuroleptics olanzapine behaved differently, i.e.…”

“…However, the atypical neuroleptics olanzapine behaved differently, i.e. it expanded monolayers from both zwitterionic and anionic phospholipids [229].…”

“…Typical examples include: antimicrobials [117,, anti-tumorals [116,, antiinflammatory [77,[214][215][216][217], anesthesics [218][219][220][221][222][223][224][225][226][227], anti-psychotics [228][229][230][231][232][233][234][235][236][237], cardiac [238][239][240][241][242][243][244][245] and antihistaminic [246] drugs. To address this issue, Langmuir monolayers have been used involving AmB alone as well as mixed with membrane sterols.…”

Anti-tumor Effects of Penfluridol through Dysregulation of Cholesterol Homeostasis

“…The reasons for such responses are unknown. Maybe, in vitro, penfluridol directly interacts with cellular membrane components, as other APDs with , which leads to further cell death as the properties of the cellular membranes are abnormally altered Maruoka et al, 2007;Steinkopf et al, 2008;Suwalsky et al, 2008). This capacity might be partly explained by the fact that the drugs disrupt cholesterol delivery, which accommodates cholesterol homeostasis.…”