The “psychomicrobiotic”: Targeting microbiota in major psychiatric disorders: A systematic review

Fond, Guillaume; Boukouaci, Wahid; Chevalier, G.; Regnault, Antoine; Eberl, Gérard; Hamdani, Nora; Dickerson, Faith; Macgregor, Alexandra; Boyer, Laurent; Dargél, Aroldo A.; Oliveira, J.; Tamouza, Ryad; Leboyer, Marion

doi:10.1016/j.patbio.2014.10.003

Cited by 173 publications

(126 citation statements)

References 129 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…As shown in Fig. 1, these include diets that facilitate the growth of good bacteria, prebiotics, probiotics, synbiotics, postbiotics, antibiotics, fecal transplantation, and activated charcoal (Critchfield et al 2011;Gilbert et al, 2013;Fond et al, 2014). The benefits of each of these adjuvant therapies will be considered.…”

Section: Therapeutic Modulation Of Gut Dysbiosis and Asdmentioning

confidence: 99%

Microbiome Disturbances and Autism Spectrum Disorders

2015

View full text Add to dashboard Cite

Autism spectrum disorders (ASDs) are considered a heterogenous set of neurobehavioral diseases, with the rates of diagnosis dramatically increasing in the past few decades. As genetics alone does not explain the underlying cause in many cases, attention has turned to environmental factors as potential etiological agents. Gastrointestinal disorders are a common comorbidity in ASD patients. It was thus hypothesized that a gut-brain link may account for some autistic cases. With the characterization of the human microbiome, this concept has been expanded to include the microbiota-gut-brain axis. There are mounting reports in animal models and human epidemiologic studies linking disruptive alterations in the gut microbiota or dysbiosis and ASD symptomology. In this review, we will explore the current evidence that gut dysbiosis in animal models and ASD patients correlates with disease risk and severity. The studies to date have surveyed how gut microbiome changes may affect these neurobehavioral disorders. However, we harbor other microbiomes in the body that might impact brain function. We will consider microbial colonies residing in the oral cavity, vagina, and the most recently discovered one in the placenta. Based on the premise that gut microbiota alterations may be causative agents in ASD, several therapeutic options have been tested, such as diet modulations, prebiotics, probiotics, synbiotics, postbiotics, antibiotics, fecal transplantation, and activated charcoal. The potential benefits of these therapies will be considered. Finally, the possible mechanisms by which changes in the gut bacterial communities may result in ASD and related neurobehavioral disorders will be examined.

show abstract

Section: Therapeutic Modulation Of Gut Dysbiosis and Asdmentioning

confidence: 99%

Microbiome Disturbances and Autism Spectrum Disorders

2015

View full text Add to dashboard Cite

show abstract

“…Archives of Psychiatry and Psychotherapy, 2016; 2: [5][6][7][8][9][10][11] The microbiome may have an impact on inducing weight gain in schizophrenia patients after antipsychotic treatment. Olanzapine administration evoked significant changes in the bacterial phyla of the gut in female rats, resulting in an increase of Firmicutes and decrease of Bacteroides.…”

Section: Schizophrenia Bipolar Disorder and The Microbiomementioning

confidence: 99%

“…An altered microbiome may result in dysregulation of immunological homeostasis, and thus it may contribute to the development of both mental disorders [45]. Similarly to patients with schizophrenia, patients with bipolar disorder present with elevated antibodies against commensal Saccharomyces cerevisiae, indicating an increased immunological response against intestinal antigens [46].…”

Section: Schizophrenia Bipolar Disorder and The Microbiomementioning

confidence: 99%

See 1 more Smart Citation

Interactions between the gut microbiome and the central nervous system and their role in schizophrenia, bipolar disorder and depression

Chrobak¹,

Nowakowski²,

Dudek³

2016

Arch Psych Psych

View full text Add to dashboard Cite

SummaryThe microbiome co-evolved with its human host over a long time and became essential for many processes. Bacteria play a role in maintaining human health as they digest food, produce vitamins and participate in the regulation of metabolism. By influencing the cytokine balance along with the composition and activity of leukocytes, they constantly interact with the immune system, affecting innate and adaptive immune homeostasis. A growing number of studies indicate that the microbiome in the human intestine may have an impact on the functions of the central nervous system (CNS), through identified pathways called the gut-brain axis. Recent data show that the human microbiome ecosystem interferes with the brain's development, central signaling systems and behavior. It has been proposed that disruption in the human microbiome may affect the course of psychiatric disorders. The aim of this review is to summarize the recognized pathways of the gut-brain axis that have been thoroughly studied in animal models and to evaluate the role of the dialogue between the microbiota and the central nervous system in schizophrenia, bipolar disorder and depression. microbiome/gut-brain axis/vagus nerve/neurotransmission/hypothalamic-pituitary-adrenal (HPA) axis

show abstract

“…In mammals, microbiome imbalance, or dysbiosis, positively correlates with the onset of obesity, diabetes, colon cancer, [14][15][16] and human psychiatric disorders such as schizophrenia and autism. [17] Currently, a large amount of research on host-microbiota mutualism employs vertebrate models, yet the high complexity of the microbial composition in the mammalian gut, the difficulty to culture most of these microbial species, and the cost of raising these animals in a strictly sterile environment pose a considerable obstacle. Therefore, to delve deeper into the molecular interplay between the host genome and the microbiome and the environmental contributions to such interplay, a more genetically tractable model organism with simpler and even defined microbiota is an attractive option.…”

mentioning

confidence: 99%