The “Prunus mume Sieb. et Zucc” (Ume) is a Rich Natural Source of Novel Anti-Cancer Substance

Adachi, Masakazu; Suzuki, Yoshihiko; Mizuta, Toshinobu; Osawa, Tatsushi; Adachi, Taro; Osaka, Kazuhisa; Suzuki, Keiji; Shiojima, Kenji; Arai, Yôko; Masuda, Kazuo; Uchiyama, Miwa; Oyamada, Takashi; Clerici, Mario

doi:10.1080/10942910600547624

Cited by 54 publications

(53 citation statements)

References 8 publications

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“…MK615 is isolated from Japanese apricot and contains many defined and undefined substances, including several triterpenoids [1] , some of which exert an antineoplastic effect. In the present study, MK615 inhibited the proliferation of all three pancreatic cancer cell lines (Figure 1), and LDH assay showed that the anti-proliferative effect of MK615 on these cells was due not only to cell anti-proliferative effect, but also to direct cell killing effect (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have revealed that MK615 has anti-neoplastic effects against gastric cancer [1] , breast cancer [2] , hepatocellular carcinoma [3] , and colon cancer [4] . The mechanisms responsible for the anti-neoplastic effect of MK615 include induction of apoptosis [1,2] and autophagy [4] , and suppression of Aurora A kinase [3] in cancer cells. However, the entire mechanisms of the anti-neoplastic effects of MK615 have not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

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MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases

Okada¹,

Sawada²,

Osawa³

et al. 2008

WJG

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases

Okada¹,

Sawada²,

Osawa³

et al. 2008

WJG

Self Cite

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“…Many chemical constituents have been isolated from Maesil extract including volatile compounds [27], hydroxycinnamic acid derivatives [26], citric acid derivative (mumefural) [7], and triterpenoids [16]. Maesil extract has been reported to show anticancer [1,13,30], antiviral [38], anti-microbial [29], anti-oxidant [37], and cardiovascular protective [35] effects. Maesil extract has been used pharmaceutically in folk medicine for antitussive, expectoration, antiemetic, antidiarrheal, anthelmintic, and antipyretic actions [26,37].…”

Section: Introductionmentioning

confidence: 99%

Extract from Prunus mume Sieb. et Zucc. Fruit Prevents LPS-induced Homotypic Aggregation of Monocytic THP-1 Cells via Suppression of Nitric Oxide Production and NF-κB Activation

Lee¹,

Park²,

Lee³

et al. 2015

Journal of Life Science

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Homotypic cell adhesion (homotypic aggregation) in activated monocytes plays a central role in physiological and pathological processes including inflammatory responses, differentiation and migration. The extract of the Prunus mume Sieb. et Zucc. fruit (Maesil) has potential benefits to human health; such as anti-viral, anti-microbial, and anti-cancer activities. Indeed, Maesil extract may modulate inflammatory responses via interference with homotypic aggregation in monocytes. In the present study, the molecular mechanisms underpinning the therapeutic efficacy of Maesil extract in inflammatory diseases were investigated. It was found that Maesil extract inhibited homotypic aggregation in lipopolysaccharide (LPS)-activated monocytes. This was mediated by reduction of nitric oxide (NO) production, partly via inhibition of inducible nitric oxide synthase (iNOS) expression in LPS-activated THP-1 cells. It was confirmed that NO inhibition is a key mechanism in Maesil induced blockade of monocyte aggregation through identification of reversal of this inhibitory effect by the NO-producing agent S-nitroso-N-acetyl penicillamine (SNAP). In addition, Maesil extract significantly attenuated LPS-induced IκB-α phosphorylation and NF-κB translocation into the nucleus. In conclusion, Maesil extract exerts anti-inflammatory effects via inhibition of homotypic aggregation of LPS-activated monocytes through mechanisms involving the suppression of NO production and NF-κB activity, suggesting Maesil extract as a potential therapeutic candidate for the prevention and treatment of chronic inflammatory diseases.

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“…the extract of ume has been reported to exert anticancer effects against gastric (3), breast (7), hepatocellular (8), colon (9) and pancreatic cancers (10). the mechanisms underlying these effects include the induction of apoptosis (3,7) and autophagy (9) and the suppression of aurora a kinase (8,10) in cancer cells.…”

mentioning

confidence: 99%

Advanced malignant melanoma responds to Prunus mume Sieb. Et Zucc (Ume) extract: Case report and in vitro study

Matsushita

Tada²,

Kikuchi³

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. malignant melanoma (mm) is an aggressive chemoresistant skin cancer characterized by rapid metastasis and a poor prognosis. therefore, the development of innovative effective therapies is critical. mK615 is an extract from the Japanese apricot Prunus mume Sieb. Et Zucc (ume). at a neutral ph, it contains natural chemical substances such as triterpenoids that exert anti-neoplastic effects in several types of cancers. We found that in patients with advanced mm, mK615 dramatically suppressed the cutaneous in-transit metastasis of the disease. pre-and post-treatment comparison of tumors showed that the apoptotic index was significantly increased by MK615. In vitro studies, MTT assay, flow cytometric cell cycle analysis and immunofluorescence microscopy revealed that MK615 inhibited the growth of SK-mEl28 cells in a dose-dependent manner, increased the proportion of cells in sub-G1 phase and induced apoptosis. We further examined the expression of the receptor for advanced glycation end products (raGE). raGE is a multi-ligand receptor that binds to a novel cytokine, high mobility group box protein 1 (hmGB1), as well as advanced glycation end products. there is evidence that raGE/hmGB1 interactions enhance cell invasion in mm. here, we present Western blotting and immunofluorescence microscopy data indicating that mK615 inhibited the expression of raGE in SK-mEl28 cells, and suppressed the release of hmGB1 by SK-MEL28 cells. Our findings suggest that MK615 may be a valuable tool for treating mm and other malignant tumors.

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The “Prunus mume Sieb. et Zucc” (Ume) is a Rich Natural Source of Novel Anti-Cancer Substance

Cited by 54 publications

References 8 publications

MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases

MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases

Extract from Prunus mume Sieb. et Zucc. Fruit Prevents LPS-induced Homotypic Aggregation of Monocytic THP-1 Cells via Suppression of Nitric Oxide Production and NF-κB Activation

Advanced malignant melanoma responds to Prunus mume Sieb. Et Zucc (Ume) extract: Case report and in vitro study

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