The Proto-Dystopia of Jerome K. Jerome

Beauchamp, Gorman

doi:10.3828/extr.1983.24.2.170

Cited by 6 publications

(3 citation statements)

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“…To save on memory and compute resources, the data were subset in parts of the MSM estimation. The MD trajectories were first strided so that the time between each frame was 1 ns in line with previous analysis in the literature. , The cluster centers were estimated on frames separated by 10 ns, i.e., only the zeroth, 10th, etc. frames were used for estimating the cluster centers.…”

Section: Methodsmentioning

confidence: 99%

Markov State Models: To Optimize or Not to Optimize

Arbon,

Zhu,

Mey

2024

J. Chem. Theory Comput.

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Markov state models (MSM) are a popular statistical method for analyzing the conformational dynamics of proteins including protein folding. With all statistical and machine learning (ML) models, choices must be made about the modeling pipeline that cannot be directly learned from the data. These choices, or hyperparameters, are often evaluated by expert judgment or, in the case of MSMs, by maximizing variational scores such as the VAMP-2 score. Modern ML and statistical pipelines often use automatic hyperparameter selection techniques ranging from the simple, choosing the best score from a random selection of hyperparameters, to the complex, optimization via, e.g., Bayesian optimization. In this work, we ask whether it is possible to automatically select MSM models this way by estimating and analyzing over 16,000,000 observations from over 280,000 estimated MSMs. We find that differences in hyperparameters can change the physical interpretation of the optimization objective, making automatic selection difficult. In addition, we find that enforcing conditions of equilibrium in the VAMP scores can result in inconsistent model selection. However, other parameters that specify the VAMP-2 score (lag time and number of relaxation processes scored) have only a negligible influence on model selection. We suggest that model observables and variational scores should be only a guide to model selection and that a full investigation of the MSM properties should be undertaken when selecting hyperparameters.

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Section: Methodsmentioning

confidence: 99%

Markov State Models: To Optimize or Not to Optimize

Arbon,

Zhu,

Mey

2024

J. Chem. Theory Comput.

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“…Since the structure of Mitchell's narrative implies a mirror play between its six stories, and considering that the workings of metafiction (HUTCHEON, 1980) and autotextuality (DALLENBACH, 1979) invite a concentric reading of the text, that is, aware of its inner relationships, then it is possible to observe the presence of utopian and dystopian elements even in the stories of this novel that are not immediately related to these two literary traditions. Thus, based on theoretical reflections on intertextuality (COMPAGNON, 1996;GENETTE, 2010;JENNY, 1979;KRISTE-VA, 2005;SAMOYAULT, 2008), dystopia (BACCOLINI; MOYLAN, 2003;BEAUCHAMP, 1983;CLAEYS, 2017), utopia and utopianism (LEVITAS, 2001;SARGENT, 2014), the present paper aims at identifying and analysing the intertextual relations David Mitchell's novel establishes with utopia and dystopia; furthermore, it also aims at reflecting upon the images through which utopianism, understood as a force that prompts transformations, is explored throughout the text. KEYWORDS: Utopia; Dystopia; Intertextuality; Cloud Atlas.…”

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confidence: 99%

“…Os dígitos após o nome são certamente uma referência a um número de série, como ocorre com produtos eletrônicos, do que se depreende que a história que o/a leitor/a acompanha nessa narrativa é a da quadringentésima quinquagésima primeira Sonmi. Neste ponto, é importante ressaltar que, como destacou Gorman Beauchamp (1983), a "numenclatura", isto é, a substituição…”

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Intertextualidade e utopismo em Atlas de nuvens, de David Mitchell

Lima

2022

RVX

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Atlas de nuvens (Cloud Atlas, 2004), de David Mitchell, é um romance que tem como traço fundamental a intertextualidade, a qual é explorada por meio de citações, alusões, e referências ao longo de toda a narrativa. Dentre os diversos intertextos presentes na obra, o diálogo com as tradições literárias da utopia e da distopia representa uma importante dimensão desse romance, tendo em vista que essa memória da literatura utópica/distópica está presente em momentos cruciais do texto. Uma vez que a forma como o romance encontra-se estruturado implica um jogo de espelhos entre cada uma das seis histórias que o compõem, e que os mecanismos da metaficção (HUTCHEON, 1980) e da autotextualidade (DALLENBACH, 1979) convidam a uma leitura concêntrica do texto, isto é, atenta às relações que a narrativa estabelece consigo mesma, é possível observar a presença de elementos utópicos e distópicos mesmo nas histórias deste romance que não estão imediatamente ligadas a essas tradições literárias. Sendo assim, com base em teorizações sobre intertextualidade (COMPAGNON, 1996; GENETTE, 2010; JENNY, 1979; KRISTEVA, 2005; SAMOYAULT, 2008), distopia (BACCOLINI; MOYLAN, 2003; BEAUCHAMP, 1983; CLAEYS, 2017), utopia e utopismo (LEVITAS, 2001; SARGENT, 2014), o presente artigo tem como objetivo identificar e analisar as relações intertextuais que o romance de David Mitchell estabelece com a utopia e a distopia, e, partir disso, tecer uma reflexão sobre as imagens por meio das quais o utopismo, enquanto força transformadora, é explorado ao longo do texto.

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Critical Dystopia

Cavalcanti

2022

The Palgrave Handbook of Utopian and Dystopian Literatures

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The Proto-Dystopia of Jerome K. Jerome

Cited by 6 publications

References 0 publications

Markov State Models: To Optimize or Not to Optimize

Markov State Models: To Optimize or Not to Optimize

Intertextualidade e utopismo em Atlas de nuvens, de David Mitchell

Critical Dystopia

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