The proteins of iridescent virus types 2 and 6

Kelly, D. C.; Tinsley, T. W.

doi:10.1016/0022-2011(72)90219-4

Cited by 58 publications

(30 citation statements)

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“…None of the proteins appears to be glycosylated (R. Goorha and A. Granoff, unpublished observation). Iridescent virus types 2 and 6 contain about 20 proteins each; the major structural protein of both viruses has a molecular weight of 65,000, with the molecular weights of other proteins ranging from 10,000 to 200,000 (Kelly and Tinsley, 1972). Polyacrylamide gel analysis of mosquito iridescent virus disclosed nine proteins, none of which reacted with Schiffs reagent, consistent with a lack of glycoproteins in these virions (Wagner et al, 1974).…”

Section: Proteinsmentioning

confidence: 93%

Icosahedral Cytoplasmic Deoxyriboviruses

Goorha

Granoff

1979

Comprehensive Virology

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Section: Proteinsmentioning

confidence: 93%

Icosahedral Cytoplasmic Deoxyriboviruses

Goorha

Granoff

1979

Comprehensive Virology

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“…wt. of approximately 65ooo (Kelly & Tinsley, 1972). The profiles of the two viruses are superficially similar, but quite distinct, probably reflecting the absence of common antigens between the two viruses.…”

Section: Chemical and Physical Properties Of The Virus Particlesmentioning

confidence: 94%

Icosahedral Cytoplasmic Deoxyriboviruses

Kelly

Robertson

1973

Journal of General Virology

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“…Upon IIV-6 infection, viral gene expression is evidenced from the synthesis of specific infected cell proteins (Barray & Devauchelle, 1985Kelly & Tinsley, 1972). The regulation of gene expression and the polypeptide composition of IIV-6 virion particles have been studied by different research groups (Barray & Devauchelle, 1979;Cerutti & Devauchelle, 1985;Kelly & Tinsley, 1972;Orange & Devauchelle, 1987).…”

Section: Introductionmentioning

confidence: 99%

“…The regulation of gene expression and the polypeptide composition of IIV-6 virion particles have been studied by different research groups (Barray & Devauchelle, 1979;Cerutti & Devauchelle, 1985;Kelly & Tinsley, 1972;Orange & Devauchelle, 1987). Studies on IIV-6 specific infected cell proteins provided evidence for three temporal classes of gene expression: immediate-early [IE or a; 0-2 h post-infection (p.i.…”

Section: Introductionmentioning

confidence: 99%

Temporal proteomic analysis and label-free quantification of viral proteins of an invertebrate iridovirus

İnce

Boeren

Oers

et al. 2015

Journal of General Virology

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Invertebrate iridescent virus 6 (IIV-6) is a nucleocytoplasmic virus with a~212 kb linear dsDNA genome that encodes 215 putative ORFs. The IIV-6 virion-associated proteins consist of at least 54 virally encoded proteins. One of our previous findings showed that most of these proteins are encoded by genes from the early transcriptional class. This indicated that these structural proteins may not only function in the formation of the virion, but also in the initial stage of viral infection. In the current study, we followed the protein expression profile of IIV-6 over time in Drosophila S2 cells by label-free quantification using a proteomic approach. A total of 95 virally encoded proteins were detected in infected cells, of which 37 were virion proteins. The expressed IIV-6 virion proteins could be categorized into three main clusters based on their expression profiles: proteins with stably low expression levels during infection, proteins with exponentially increasing expression levels during infection and proteins that were initially highly abundant, but showed slightly reduced levels after 48 h post-infection. We thus provided novel information on the kinetics of virion and infected cell-specific protein levels that assists in our understanding of gene regulation in this lesser-known DNA virus model.

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The proteins of iridescent virus types 2 and 6

Cited by 58 publications

References 0 publications

Icosahedral Cytoplasmic Deoxyriboviruses

Icosahedral Cytoplasmic Deoxyriboviruses

Icosahedral Cytoplasmic Deoxyriboviruses

Temporal proteomic analysis and label-free quantification of viral proteins of an invertebrate iridovirus

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