The protective role of vitamin E on gill and liver tissue histopathology and micronucleus frequencies in peripheral erythrocytes of Oreochromis niloticus exposed to deltamethrin

Kan, Yeter; Cengiz, Elif İpek; Uğurlu, Pelin; Yanar, Mahmut

doi:10.1016/j.etap.2012.03.009

Cited by 41 publications

(16 citation statements)

References 33 publications

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“…Vitamin E is a group of fatsoluble compounds, including d-alpha-tocopherol, which has strong antioxidant activity [44]. Our result is consistent with previous studies that demonstrated the protective effects of vitamin E against the genotoxicity of several agents such as deltamethrin and patulin [45,46]. Thus, vitamin E has the potential to be used as a protective drug against the genotoxicity associated with mutagenic agents and diseases.…”

Section: Discussionsupporting

confidence: 93%

Genotoxicity assessment in iron deficiency anemia patients using sister chromatid exchanges and chromosomal aberrations assays

Khabour

Soudah

Aaysh

2013

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Section: Discussionsupporting

confidence: 93%

Genotoxicity assessment in iron deficiency anemia patients using sister chromatid exchanges and chromosomal aberrations assays

Khabour

Soudah

Aaysh

2013

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…Exposure of zebrafish embryos to pyrethroids caused a dose-dependent increase in mortality and pericardial edema, with Type II compounds being the most potent and as doses approaching the LC50, permethrin and deltamethrin caused craniofacial abnormalities (DeMicco et al 2010). The study by Kan et al (2012) suggested deltamethrin to be the causative agents for creating micronucleus and altering the histopathology of liver and gills of Oreochromis niloticus.…”

Section: Histopathological Alterationsmentioning

confidence: 94%

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Prusty¹,

Meena

Mohapatra

et al. 2015

Int Aquat Res

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As a new class of agricultural insecticides, synthetic pyrethroids are widely used to control insect pests. Synthetic pyrethroids have been shown to enter the aquatic environment from agricultural runoff or drift from aerial and ground-based spraying applications posing threat to fishes which are less tolerant to pesticides through direct exposure. These insecticides interfere with the sodium channel of the nervous system resulting in prolonged sodium tail current. Widespread application of these chemicals has warranted the attention of the ecologist to understand the impact of these chemicals on the aquatic environment. In this perspective, an updated account of toxicological evaluation of three type II synthetic pyrethroids, viz. deltamethrin, cypermethrin and fenvalerate in terms of their physico-chemical, metabolic, hematological, histological, behavioral and reproductive aspects with respect to the fishes has been presented which may be useful for policy makers, academics, environmental scientists and agricultural professionals needing ready access to this information. The aim of the present synoptic literature appraisal was to summarize the main effect of current use, type II synthetic pyrethroids (deltamethrin, cypermethrin and fenvalerate) on aquatic environment due to their persistence and accumulation. This article will focus on non-target organisms in inland fresh water environment with special reference to fin fishes and will critically evaluate the toxicity of these pyrethroids in terms of growth inhibition, metabolic disorders, neurotoxicity, reproductive failure, enzymatic dysfunction, haematological alterations, and tissue damages. The rationalized information in this milieu may be useful in ecological risk evaluation and human health management as fish serves as an important bio-indicator for aquatic systems health.

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“…Kan et al () observed that vitamin E decreased the histopathological changes induced in gills and liver of O. niloticus by deltamethrin exposure for 30 days, but it did not confer a complete protection. Mekkawy et al () noticed that gills of Cd‐exposed tilapia exhibited severs hyperplasia, proliferation of chloride cells, shortened length and reduced secondary gill lamellae.…”

Section: Discussionmentioning

confidence: 99%

Vitamin E pretreatment prevents histopathological effects in tilapia (Oreochromis niloticus) acutely exposed to cylindrospermopsin

Guzmán-Guillén

Prieto

Gutiérrez-Praena

et al. 2015

Environmental Toxicology

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Cylindrospermopsin (CYN) is a cyanotoxin frequently involved in blooms with a predominantly extracellular availability, which makes it easily taken up by a variety of aquatic organisms. CYN is a potent protein and glutathione synthesis inhibitor, and also induces genotoxicity, oxidative stress and several histopathological lesions. The present study investigates the protective role of a vitamin E pretreatment (700 mg vit E/kg fish bw/day, for 7 days) on the histopathological alterations induced in different organs of tilapia (Oreochromis niloticus) acutely exposed to a single oral dose of 400 µg pure CYN/kg bw fish. The major histological changes observed were degenerative glucogenic process and loss of the hepatic structure in the liver, glomerulopathy and tubular tumefaction in the kidney, myofibrolysis and edema in the heart, catarrhal enteritis and necrosis in the gastrointestinal tract, hyperemic processes in the gill lamellae, and high basophilia, degeneration and tumefaction of granular neurons in the brain. Vitamin E pretreatment was effective in preventing or ameliorating the abovementioned alterations induced by CYN. In addition, a morphometric study indicated that the average nuclear diameter of hepatocytes, and cross-sections of proximal and distal convoluted tubules, together with the cardiac fiber and capillaries diameters represent a useful tool to evaluate the damage induced by CYN. This is the first study reporting vitamin E prevention of histopathological damage in tissues (liver, kidney, heart, gastrointestinal tract, gills and brain) of fish intoxicated with CYN. Therefore, vitamin E can be considered a useful chemoprotectant in the treatment of histopathological changes induced in CYN-intoxicated fish. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1469-1485, 2016.

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The protective role of vitamin E on gill and liver tissue histopathology and micronucleus frequencies in peripheral erythrocytes of Oreochromis niloticus exposed to deltamethrin

Cited by 41 publications

References 33 publications

Genotoxicity assessment in iron deficiency anemia patients using sister chromatid exchanges and chromosomal aberrations assays

Genotoxicity assessment in iron deficiency anemia patients using sister chromatid exchanges and chromosomal aberrations assays

Synthetic pyrethroids (Type II) and freshwater fish culture: Perils and mitigations

Vitamin E pretreatment prevents histopathological effects in tilapia (Oreochromis niloticus) acutely exposed to cylindrospermopsin

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