The Protective Role of Vitamin C against Formaldehyde inducedhepatotoxicity and nephrotoxicity in Male Rats

Abdulqader, Shang Z.; A.Mustafa, Inaam

doi:10.9790/3008-09432126

IOSRJPBS

2014

DOI: 10.9790/3008-09432126

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The Protective Role of Vitamin C against Formaldehyde inducedhepatotoxicity and nephrotoxicity in Male Rats

Shang Z. Abdulqader¹,

Inaam A.Mustafa²

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Cited by 3 publications

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“…Many researchers proved the protective effect of vitamin C against histological changes induced by formaldehyde. 20,21 Also vitamin C as chemo protective agent was proved by Al-jammas S.,2011 after he injected rats with vitamin C prior to cisplatineum result in improvements in the microscopical changes induced by cisplatineum.…”

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confidence: 99%

The Role of Vitamin C on the Structural Changes of Male Albino Rats Kidney Induced by Tramadol

Ahmad¹,

AL-Hubaity²,

Alazow³

2019

Ann Coll Med Mosul

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Aim of study: The aim of this work is to detect the toxic effects of tramadol on the microscopic structure of the kidneys of adult male albino rats, and the possible protective role of vitamin C against these toxic effects. Method: Thirty adult albino rats are used in this study. The animals were divided into three equal groups: Group A (control group): Animals were injected daily with normal saline for 4 weeks. Group B (Tramadol treated group) (TGI): Animals were injected daily with tramadol in a dose of 50mg/kg b.wt for 4 weeks. Group C (group treated with tramadol+vitamin C) (TGII): Animals were injected with vitamin C in a dose 100mg/Kg/b.wt half hour prior to tramadol injection in the same dose as in group B for 4 weeks. The injection was given intraperitoneally for all animals. At the end of the experiments, the rats were anaesthetized by ether, then killed. After that kidneys removed, fixed in formaldehyde and processed for microscopic examination. Result: Tramadol causes shrinkage of renal glomeruli with widening of bowman's space. Renal tubules showed hydropic degeneration and vacuolization of their epithelial cells. Infiltration of mononuclear cells along with Hyaline cast is seen within the degenerated tubules. Giving vitamin C prior to tramadol injection results in improvement in the microscopical structure of kidney mainly in glomeruli and tubules. Conclusion: Using tramadol caused damage to renal glomeruli and tubules in renal cortex. The addition of vitamin C partially improved the histological structure of kidney.

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The Role of Vitamin C on the Structural Changes of Male Albino Rats Kidney Induced by Tramadol

Ahmad¹,

AL-Hubaity²,

Alazow³

2019

Ann Coll Med Mosul

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Histological study of adult male albino rats’ hepatocytes after formaldehyde administration and the possible protective role of dill oil

Solaiman

El-Agawany

2015

The Egyptian Journal of Histology

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Histological Effect of Formaldehyde as Food Preservative on Cerebellar Cortex of Albino Rat

Farhoud

El-Soud

2019

The Medical Journal of Cairo University

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Background: Formaldehyde is an important chemical compound that is used widely in the industrial and medical setting. It is illegally used in excess amounts to preserve various kinds of foods that can affect the central nervous system particularly the cerebellar cortex. Aim of Study: This work aims to evaluate the extent of histological changes of the cerebellar cortex of albino rat's offspring that may be induced by oral administration of formaldehyde to their mothers throughout pregnancy and lactation or direct administration to the offspring itself. Material and Methods: The maximum dietary dose of formaldehyde (41.9mg/person/day) was used in this work. The used doses according to rat age were 0.74mg/adult, 0.104mg/ 2 weeks and 0.240mg/4 weeks. In this work, 42 pregnant albino rats and 120 of their offspring were used. They divided into 2 main groups; control and treated groups. The control group (Group C) consisted of 12 pregnant rats and 60 of their offspring. They were divided equally into C1, C2 and C3. The treated group (Group T) consisted of 30 pregnant rats and 60 of their offspring. They were divided equally into T1, T2 and T3. The pregnant rats of C1 and T1 received distilled water and formaldehyde respectively throughout pregnancy and for 2 weeks after delivery, then the 2 weeks old offspring received distilled water and formaldehyde respectively till the end of 8 weeks. The delivered rats of C2 and T2 received distilled water and formaldehyde respectively for 2 weeks. Then the 2 weeks old offspring received distilled water and formaldehyde respectively till the end of 8 weeks. The 2 weeks old offspring of C3 and T3 received distilled water and formaldehyde respectively till the end of 8 weeks. The cerebelli of all groups were extracted at two ages, at 4 and 8 weeks and immersed into suitable fixatives then prepared for light microscopic examination, in addition, the cerebelli of 8 weeks offspring were used for electron microscopic examination and morphometric studies. Results: In the present work, oral administration of formaldehyde induced delayed development of all layers of the cerebellar cortex in form of irregularity and change in the shape and size of cells, decreased the thickness of its layers. It also induced degenerative changes in the form of cytoplasmic

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The Protective Role of Vitamin C against Formaldehyde inducedhepatotoxicity and nephrotoxicity in Male Rats

Cited by 3 publications

References 25 publications

The Role of Vitamin C on the Structural Changes of Male Albino Rats Kidney Induced by Tramadol

The Role of Vitamin C on the Structural Changes of Male Albino Rats Kidney Induced by Tramadol

Histological study of adult male albino rats’ hepatocytes after formaldehyde administration and the possible protective role of dill oil

Histological Effect of Formaldehyde as Food Preservative on Cerebellar Cortex of Albino Rat

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