The protective role of nutritional antioxidants against oxidative stress in thyroid disorders

Mačvanin, Mirjana; Gluvić, Zoran; Zafirović, Sonja; Gao, Xin; Essack, Magbubah; Isenović, Esma R.

doi:10.3389/fendo.2022.1092837

Cited by 10 publications

(25 citation statements)

References 242 publications

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“…[2] May emphasize critical care aspects over specific diagnostic criteria. [2] Relevant when thyroid storm presents in a critical care setting. [2] Institutional or Regional Guidelines March 9, 2023 -Specific guidelines followed by the healthcare institution or region where the article is applicable.…”

Section: Challenges and Controversiesmentioning

confidence: 99%

“…[2] Relevant when thyroid storm presents in a critical care setting. [2] Institutional or Regional Guidelines March 9, 2023 -Specific guidelines followed by the healthcare institution or region where the article is applicable. [1] May vary but should be consistent with national or international guidelines.…”

Section: Challenges and Controversiesmentioning

confidence: 99%

“…[7] These criteria collectively provide a nuanced and comprehensive approach to identifying thyroid storm, reflecting the evolution of diagnostic methodologies. [1][2][3][4][5][6][7]…”

Section: Commonly Used Diagnostic Criteria For Thyroid Stormmentioning

confidence: 99%

“…Without swift and appropriate treatment, it can lead to catastrophic consequences, including cardiac arrhythmias, organ failure, and even death. [1,2]…”

Section: Introductionmentioning

confidence: 99%

“…This intricate web of symptoms poses a diagnostic challenge, where misdiagnosis can result in inappropriate treatments and delays in addressing the underlying thyroid dysfunction or the root cause of the symptoms. [2]…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic criteria and scoring systems for thyroid storm: An evaluation of their utility – comparative review

Elendu,

Amaechi,

Amaechi

et al. 2024

Medicine

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A thyroid storm is a life-threatening endocrine emergency characterized by severe hyperthyroidism and many systemic manifestations. Prompt recognition and treatment are essential for patient survival. This study evaluates the utility of existing diagnostic criteria and scoring systems for thyroid storm. A comprehensive literature review encompassed articles published up to December 2023. Various diagnostic criteria and scoring systems, such as the Burch–Wartofsky Point Scale and the Japanese Thyroid Association criteria, were critically assessed based on their sensitivity, specificity, and clinical applicability. Our findings reveal that existing diagnostic criteria and scoring systems, although valuable tools, exhibit limitations. They may lack sensitivity in identifying milder cases of thyroid storm or fail to differentiate it from other critical conditions. Furthermore, some criteria rely heavily on subjective clinical Judgment, which can vary among healthcare providers. Future research should focus on refining existing criteria and developing more objective and universally applicable diagnostic tools to address these limitations. Incorporating advanced laboratory markers and modern imaging techniques may enhance diagnostic accuracy. Additionally, a standardized scoring system approach could improve clinical practice consistency. In conclusion, while current diagnostic criteria and scoring systems provide a foundation for identifying thyroid storm, their utility has shortcomings. Advancements in diagnostic methods and a collaborative effort to establish standardized criteria are imperative to enhance the accuracy and reliability of thyroid storm diagnosis, ultimately improving patient outcomes.

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Section: Challenges and Controversiesmentioning

confidence: 99%

Section: Challenges and Controversiesmentioning

confidence: 99%

“…[7] These criteria collectively provide a nuanced and comprehensive approach to identifying thyroid storm, reflecting the evolution of diagnostic methodologies. [1][2][3][4][5][6][7]…”

Section: Commonly Used Diagnostic Criteria For Thyroid Stormmentioning

confidence: 99%

“…Without swift and appropriate treatment, it can lead to catastrophic consequences, including cardiac arrhythmias, organ failure, and even death. [1,2]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diagnostic criteria and scoring systems for thyroid storm: An evaluation of their utility – comparative review

Elendu,

Amaechi,

Amaechi

et al. 2024

Medicine

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The relationship between thyroid and human-associated microbiota: A systematic review of reviews

Virili,

Stramazzo,

Bagaglini

et al. 2023

Rev Endocr Metab Disord

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In recent years, a growing number of studies have examined the relationship between thyroid pathophysiology and intestinal microbiota composition. The reciprocal influence between these two entities has been proven so extensive that some authors coined the term "gut-thyroid axis". However, since some papers reported conflicting results, several aspects of this correlation need to be clarified. This systematic review was conceived to achieve more robust information about: 1)the characteristics of gut microbiota composition in patients with the more common morphological, functional and autoimmune disorders of the thyroid; 2)the influence of gut microbial composition on micronutrients that are essential for the maintenance of thyroid homeostasis; 3)the effect of probiotics, prebiotics and synbiotics, some of the most popular over-the-counter products, on thyroid balance; 4)the opportunity to use specific dietary advice. The literature evaluation was made by three authors independently. A five steps strategy was a priori adopted. After duplicates removal, 1106 records were initially found and 38 reviews were finally included in the analysis. The systematic reviews of reviews found that: 1) some significant variations characterize the gut microbiota composition in patients with thyroid disorders. However, geographical clustering of most of the studies prevents drawing definitive conclusions on this topic; 2) the available knowledge about the effect of probiotics and synbiotics are not strong enough to suggest the routine use of these compounds in patients with thyroid disorders; 3) specific elimination nutrition should not be routine suggested to patients, which, instead have to be checked for possible micronutrients and vitamins deficiency, often owed to gastrointestinal autoimmune comorbidities.

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Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats

Kawara,

Moawed,

Elsenosi

et al. 2024

BMC Complement Med Ther

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Background Melissa officinalis (MO) is a well-known medicinal plant species used in the treatment of several diseases; it is widely used as a vegetable, adding flavour to dishes. This study was designed to evaluate the therapeutic effect of MO Extract against hyperthyroidism induced by Eltroxin and γ-radiation. Methods Hyperthyroidism was induced by injecting rats with Eltroxin (100 µg/kg/ day) for 14 days and exposure to γ-radiation (IR) (5 Gy single dose). The hyperthyroid rats were orally treated with MO extract (75 mg/kg/day) at the beginning of the second week of the Eltroxin injection and continued for another week. The levels of thyroid hormones, liver enzymes and proteins besides the impaired hepatic redox status and antioxidant parameters were measured using commercial kits. The hepatic gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its inhibitor Kelch-like ECH-associated protein-1(Keap-1) in addition to hepatic inflammatory mediators including tumor necrosis factor-α (TNF- α), Monocyte chemoattractant protein-1 (MCP-1) and fibrogenic markers such as transforming growth factor-beta1 (TGF-β1) were determined. Results MO Extract reversed the effect of Eltroxin + IR on rats and attenuated the thyroid hormones. Moreover, it alleviated hyperthyroidism-induced hepatic damage by inhibiting the hepatic enzymes’ activities as well as enhancing the production of proteins concomitant with improving cellular redox homeostasis by attenuating the deranged redox balance and modulating the Nrf2/Keap-1 pathway. Additionally, MO Extract alleviated the inflammatory response by suppressing the TNF- α and MCP-1 and prevented hepatic fibrosis via Nrf2-mediated inhibition of the TGF-β1/Smad pathway. Conclusion Accordingly, these results might strengthen the hepatoprotective effect of MO Extract in a rat model of hyperthyroidism by regulating the Nrf-2/ Keap-1 pathway.

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The protective role of nutritional antioxidants against oxidative stress in thyroid disorders

Cited by 10 publications

References 242 publications

Diagnostic criteria and scoring systems for thyroid storm: An evaluation of their utility – comparative review

Diagnostic criteria and scoring systems for thyroid storm: An evaluation of their utility – comparative review

The relationship between thyroid and human-associated microbiota: A systematic review of reviews

Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats

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