The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

Bacanlı, Merve; Aydın, Sevtap; Taner, Gökçe; Göktaş, Hatice Gül; Sahin, Tevfik Tolga; Başaran, Ahmet; Başaran, Nurşen

doi:10.1016/j.etap.2014.08.018

Cited by 47 publications

(28 citation statements)

References 58 publications

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“…The severity of tissue injury induced by sepsis is correlated with TNF-alpha level and there is a relation between inflammation and oxidative stress (26). In our study, as in our previous data (13)(14)(15), plasma TNF-alpha levels significantly increased in the septic rats, indicating an inflammatory response to sepsis. Single and double DNA strand breaks, base modifications, fragmentation of deoxyribose, formation of DNA-protein cross-links as well as abasic sites may occur as a result of oxidative DNA damage.…”

Section: Discussionsupporting

confidence: 77%

“…The decreases in GSH and increases in MDA levels were determined in the hepatic and renal tissues of septic rats (25). In our study, as for our previous data (13)(14)(15), the increases in MDA levels and decreases in GSH levels and SOD and GPX activities in the liver and kidney were shown in the septic rats compared to the sham group.…”

Section: Discussionsupporting

confidence: 70%

“…At the studied dose, 100% of the animals remained alive. In our previous studies with the phenolic compounds pycnogenol®, ferulic acid, and rosmarinic acid, the dosages of 100 mg/kg bw ip were also used in the experimental sepsis model (13)(14)(15). In these studies evaluated independently form the same local animal ethic approval to reduce animal numbers according to the principles of 3Rs, sham and sepsis groups were common; thus the data from sham and sepsis groups were the same in these studies carried out at the same time (13)(14)(15)(16).…”

Section: Experimental Designmentioning

confidence: 99%

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Resveratrol Protects Sepsis-Induced Oxidative DNA Damage in Liver and Kidney of Rats

Aydın¹,

Şahin²,

Bacanlı³

et al. 2016

Balkan Med J

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Background:The increases of free radicals have been proposed to be involved in the pathogenesis of sepsis, which leads to multiple-organ dysfunction syndromes. The uses of antioxidants as a complementary tool in the medical care of oxidative stress-related diseases have attracted attention of researchers. Resveratrol (RV) has suggested being antioxidant, anti-proliferative, and anti-inflammatory effects in various experimental models and clinical settings. Aims: This study was undertaken to evaluate the protective effects of RV on oxidative DNA damage induced by sepsis in the liver and kidney tissues of Wistar albino rats. Study Design: Animal experimentation. Methods: Four experimental groups consisting of eight animals for each was created using a total of thirty-two male Wistar albino rats. Sham group was given 0.5 mL of saline intra-peritoneal (ip) only following laparatomy. Sepsis group was given 0.5 mL saline ip only following the induction of sepsis. RV-treated group was given a dose of 100 mg/kg ip RV in 0.5 mL saline following laparatomy. RVtreated sepsis group was given 100 mg/kg ip RV in 0.5 mL saline following the induction of sepsis. A model of sepsis was created by cecal ligation and puncture technique. In the liver and kidney tissues, oxidative stress parameters (malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPX)) and a proinflammatory cytokine (tumor necrosis factor alpha (TNF-alpha)), were evaluated spectrophotometrically and DNA damage was determined by the alkaline single cell gel electrophoresis (comet assay) technique using formamidopyrimidine DNA glycosylase protein. Results:In the RV-treated sepsis group, the levels of MDA and TNF-alpha were lower and GSH levels, SOD and GPX activities were higher than in the septic rats (p<0.05). RV treatment significantly reduced the sepsis-induced oxidative DNA damage in the liver and kidney cells (p<0.05). Conclusion: It is suggested that RV treatment might reduce the sepsis-induced oxidative DNA damages in sepsis-related diseases; however, there is a need for more studies to clear up the protective mechanisms of RV against sepsis.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 70%

Section: Experimental Designmentioning

confidence: 99%

See 1 more Smart Citation

Resveratrol Protects Sepsis-Induced Oxidative DNA Damage in Liver and Kidney of Rats

Aydın¹,

Şahin²,

Bacanlı³

et al. 2016

Balkan Med J

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“…A wide spectrum of therapeutic effects has been advocated for FA against various diseases, including cancer, diabetes, and cardiovascular and neurodegenerative diseases, which is ascribed to its potent antioxidant activity (Chigorimbo-Murefu et al 2009;Bacanlı et al 2014;Liang et al 2014). FA has also been reported as anti-inflammatory (Gohil et al 2012;Murakami et al 2002), anti-diabetic (Mancuso and Santangelo 2014;Ohnishi et al 2004;Song et al 2014), hepatoprotective (Krishnan et al 2013;Kim et al 2011;Al Maruf et al 2015;Panneerselvam et al 2013), anti-hyperlipidemic, andanti-atherogenic (Marimuthu et al 2013;Kwon et al 2010), neuroprotective Koh 2012Koh , 2013, anti-cancer, and anti-apoptotic effects (Serafim et al 2011;Thakkar et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Ferulic acid ameliorates chronic constriction injury induced painful neuropathy in rats

Aswar

Patil²

2016

Inflammopharmacol

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“…The Alkaline Comet assay technique of Singh et al 29 , as further described by Collins 30 and Bacanlı et al 31 was followed. The cells were suspended in 75 µL of 0.5% LMA.…”

Section: Determination Of Dna Damagementioning

confidence: 99%

The Ameliorative Effects of Pycnogenol<sup>®</sup> on Liver Ischemia-Reperfusion Injury in Rats

Tokaç¹,

Bacanlı²,

Dumlu³

et al. 2017

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The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

Cited by 47 publications

References 58 publications

Resveratrol Protects Sepsis-Induced Oxidative DNA Damage in Liver and Kidney of Rats

Resveratrol Protects Sepsis-Induced Oxidative DNA Damage in Liver and Kidney of Rats

Ferulic acid ameliorates chronic constriction injury induced painful neuropathy in rats

The Ameliorative Effects of Pycnogenol<sup>®</sup> on Liver Ischemia-Reperfusion Injury in Rats

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