The Protective Properties of Milk and Colostrum in Non-Human Species

Tizard, Ian R.

doi:10.1007/978-1-4615-0661-4_7

Cited by 8 publications

(6 citation statements)

References 125 publications

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“…Similar to horses, pigs, and ruminants, the epitheliochorial placenta of camels does not allow trans-placental passage of maternal immunoglobulins to the fetus (172,173). Therefore, the newborn camel calf is born without serum immunoglobulins and postnatal protection mainly relies on an adequate absorption of maternal colostral antibodies until the maturation of the calf's own immune system (174,175). The transfer of colostral immunoglobulins to the newborn camel calf has been subject of many investigations (176)(177)(178)(179)(180)(181)(182).…”

Section: The Immune System Of the Newborn Camel Calfmentioning

confidence: 99%

Recent Advances in Camel Immunology

Hussen

Schuberth

2021

Front. Immunol.

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Camels are domesticated animals that are highly adapted to the extreme desert ecosystem with relatively higher resistance to a wide range of pathogens compared to many other species from the same geographical region. Recently, there has been increased interest in the field of camel immunology. As the progress in the analysis of camel immunoglobulins has previously been covered in many recent reviews, this review intends to summarize published findings related to camel cellular immunology with a focus on the phenotype and functionality of camel leukocyte subpopulations. The review also describes the impact of different physiological (age and pregnancy) and pathological (e.g. infection) conditions on camel immune cells. Despite the progress achieved in the field of camel immunology, there are gaps in our complete understanding of the camel immune system. Questions remain regarding innate recognition mechanisms, the functional characterization of antigen-presenting cells, and the characterization of camel NK and cytotoxic T cells.

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Section: The Immune System Of the Newborn Camel Calfmentioning

confidence: 99%

Recent Advances in Camel Immunology

Hussen

Schuberth

2021

Front. Immunol.

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“…Although that environment is primarily geared toward digestion to gain nutritional benefit, the immunoglobulins remain sufficiently stable to provide protective benefits for the neonate, either through uptake into the vascular system in the newborn of some species or through immunological function in the gastrointestinal tract. The immunoglobulins found in milk and the transfer of passive immunity from mother to neonate have been reviewed by many authors, with a partial listing referenced here [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Perspectives on Immunoglobulins in Colostrum and Milk

2011

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Immunoglobulins form an important component of the immunological activity found in milk and colostrum. They are central to the immunological link that occurs when the mother transfers passive immunity to the offspring. The mechanism of transfer varies among mammalian species. Cattle provide a readily available immune rich colostrum and milk in large quantities, making those secretions important potential sources of immune products that may benefit humans. Immune milk is a term used to describe a range of products of the bovine mammary gland that have been tested against several human diseases. The use of colostrum or milk as a source of immunoglobulins, whether intended for the neonate of the species producing the secretion or for a different species, can be viewed in the context of the types of immunoglobulins in the secretion, the mechanisms by which the immunoglobulins are secreted, and the mechanisms by which the neonate or adult consuming the milk then gains immunological benefit. The stability of immunoglobulins as they undergo processing in the milk, or undergo digestion in the intestine, is an additional consideration for evaluating the value of milk immunoglobulins. This review summarizes the fundamental knowledge of immunoglobulins found in colostrum, milk, and immune milk.

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“…Mammalian neonates generally receive immune protection from milk (or colostrum) immediately after birth. In marsupials in particular, the newborn, which does not receive any passive immunity during foetal development, lacks a mature immune system and this renders them more vulnerable to pathogenic infections and therefore they are highly dependent on maternal immune source via milk for adequate protection [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii)

et al. 2014

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BackgroundLactation is a key aspect of mammalian evolution for adaptation of various reproductive strategies along different mammalian lineages. Marsupials, such as tammar wallaby, adopted a short gestation and a relatively long lactation cycle, the newborn is immature at birth and significant development occurs postnatally during lactation. Continuous changes of tammar milk composition may contribute to development and immune protection of pouch young. Here, in order to address the putative contribution of newly identified secretory milk miRNA in these processes, high throughput sequencing of miRNAs collected from tammar milk at different time points of lactation was conducted. A comparative analysis was performed to find distribution of miRNA in milk and blood serum of lactating wallaby.ResultsResults showed that high levels of miRNA secreted in milk and allowed the identification of differentially expressed milk miRNAs during the lactation cycle as putative markers of mammary gland activity and functional candidate signals to assist growth and timed development of the young. Comparative analysis of miRNA distribution in milk and blood serum suggests that milk miRNAs are primarily expressed from mammary gland rather than transferred from maternal circulating blood, likely through a new putative exosomal secretory pathway. In contrast, highly expressed milk miRNAs could be detected at significantly higher levels in neonate blood serum in comparison to adult blood, suggesting milk miRNAs may be absorbed through the gut of the young.ConclusionThe function of miRNA in mammary gland development and secretory activity has been proposed, but results from the current study also support a differential role of milk miRNA in regulation of development in the pouch young, revealing a new potential molecular communication between mother and young during mammalian lactation.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2164-15-1012) contains supplementary material, which is available to authorized users.

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The Protective Properties of Milk and Colostrum in Non-Human Species

Cited by 8 publications

References 125 publications

Recent Advances in Camel Immunology

Recent Advances in Camel Immunology

Perspectives on Immunoglobulins in Colostrum and Milk

Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii)

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