The protective mechanism of<i>Lactobacillus plantarum</i>FZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet

Chen, Min; Guo, Weiling; Li, Qiuyi; Xu, Jiaxin; Cao, Ying-Jia; Liu, Bin; Yu, Xiaodan; Rao, Pingfan; Ni, Li; Lv, Xu-Cong

doi:10.1039/c9fo03003d

Cited by 61 publications

(40 citation statements)

References 60 publications

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“…Obesity and hyperglycemia induced by an HFD were closely associated with the gut microbiota dysbiosis, which has been confirmed in this study. In addition, recent researches have also demonstrated that probiotics intervention exhibited promising roles, such as antiobesity and insulin sensitivity by restoring the balance of the intestine microorganisms in murine models (24,33). In this study, B2 intervention decreased the α-diversity in comparison with the HFD group, indicating that B2 characteristically altered the gut bacterial community.…”

Section: Discussionsupporting

confidence: 51%

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

et al. 2021

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Lactobacillus plantarum ZJUFB2 is a novel probiotic isolate derived from Chinese traditional sourdough that possesses promising probiotics properties. This study aimed to investigate the effects of L. plantarum ZJUFB2 (B2) on insulin sensitivity using mice fed on a high-fat diet (HFD) as well as to explore the involved mechanisms. Purposely, male C57BL/6 mice continuously received an intervention of B2 (~109 CFU/day) for 16 weeks. The results showed that B2 treatment remarkably ameliorated insulin resistance and hyperglycemia in HFD-fed mice. The B2 intervention significantly decreased the hepatic lipid accumulation, serum low-density lipoproteins cholesterol, and lipopolysaccharides, and regulated the bile acids levels as well as liver mRNA expression involved in lipid metabolism. Moreover, the B2 intervention significantly changed the gut microbiota, specifically, showed a lower abundance of obesity-related and inflammation-associated microbes, e.g., Ruminococcus and Mogibacteriaceae. Furthermore, it exhibited a higher abundance of short-chain fatty acids and bile salt hydrolas-producing bacteria, such as Bifidobacterium and F16 compared with the HFD group. The findings of this study suggested that B2 is a novel probiotic, effective in preventing insulin resistance by improving the gut microbiota and bile acids.

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Section: Discussionsupporting

confidence: 51%

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

et al. 2021

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“…Steatosis and TG accumulation in liver tissue were reduced, and glycogen content in liver tissue was increased by administering MG4296 and MG5012. In a previous study, L. plantarum FZU3013 improved NAFLD and hyperlipidemia in mice fed an HFD [57]. L. GG improved hepatic steatosis in HFD-induced mice [58].…”

Section: Discussionmentioning

confidence: 76%

Lactiplantibacillus plantarum MG4296 and Lacticaseibacillus paracasei MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice

et al. 2021

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The purpose of this study was to evaluate the capacity of Lactiplantibacillus plantarum MG4296 (MG4296) and Lacticaseibacillus paracasei MG5012 (MG5012) on insulin resistance (IR) and diabetes-related metabolic changes in palmitic acid (PA)-induced HepG2 cells and high-fat diet-induced mice. In vitro, cell-free extracts of MG4296 and MG5012 alleviated IR by increasing glucose uptake and glycogen content in PA-induced insulin-resistant HepG2 cells. In vivo, MG4296 and MG5012 supplementation markedly decreased body weight and glucose tolerance. Administration of both strains also improved serum glucose, glycated hemoglobin, insulin, triglyceride, LDL/HDL ratio, and homeostatic model assessment of IR (HOMA-IR). Histopathological analysis of liver tissue demonstrated a significant reduction in lipid accumulation and glycogen content. Moreover, MG4296 and MG5012 treatment enhanced phosphoinositide-3 kinase (PI3K)/protein kinase B (Akt) expression in the liver. Overall, MG4296 and MG5012 could prevent HFD-induced glucose tolerance and hyperglycemia by improving IR. Therefore, L. plantarum MG4296 and L. paracasei MG5012 could be useful as new probiotics candidates to improve T2DM.

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“…In general, patients with dyslipidemia also suffer from nonalcoholic fatty liver disease (NAFLD), and clinical manifestations include excessive accumulation of lipids, including TG and FAs, in hepatocytes [68]. Previous studies suggested that the gut microbiome is involved in the development of dyslipidemia and NAFLD [69], whereas the intestine and liver are intrinsically linked and strongly interdependent in metabolic functions [70,71]. For example, common buckwheat consumption significantly improved physiological indexes and biochemical parameters related to dyslipidemia and NAFLD in mice fed with an HFD.…”

Section: Nonalcoholic Fatty Liver Diseasementioning

confidence: 99%

The Beneficial Effect of Coarse Cereals on Chronic Diseases through Regulating Gut Microbiota

Ren

Fan

Teng

et al. 2021

Foods

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In recent years, chronic diseases including obesity, diabetes, cancer, cardiovascular, and neurodegenerative disorders have been the leading causes of incapacity and death globally. Increasing evidence suggests that improvements of lifestyle habits and diet is the most commonly adopted strategy for the prevention of chronic disorders. Moreover, many dietary compounds have revealed health-promoting benefits beyond their nutritional effects. It is worth noting that diet plays an important role in shaping the intestinal microbiota. Coarse cereals constitute important sources of nutrients for the gut microbiota and contribute to a healthy gut microbiome. Furthermore, the gut microbiota converts coarse cereals into functional substances and mediates the interaction between the host and these components. In this study, we summarize the recent findings concerning functional components of cereal grains and their potential chemopreventive activity via modulating the gut microbiota.

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The protective mechanism ofLactobacillus plantarumFZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet

Abstract: Lactobacillus plantarum FZU3013, isolated from the traditional brewing process of Hongqu rice wine, has beneficial effects on improving lipid metabolism disorders.

Cited by 61 publications

References 60 publications

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota

Lactiplantibacillus plantarum MG4296 and Lacticaseibacillus paracasei MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice

The Beneficial Effect of Coarse Cereals on Chronic Diseases through Regulating Gut Microbiota

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