The protective effects of taurine and fish oil supplementation on PM2.5-induced heart dysfunction among aged mice: A random double-blind study

Contribution and Effects of PM2.5-Bound Lead to the Cardiovascular Risk of Workers in a Non-Ferrous Metal Smelting Area Considering Chemical Speciation and Bioavailability

“…The heart rate of the high dosage groups and Pb­(Ac) 2 -group initially increased but then decreased. The Pb­(Ac) 2 -group showed the earliest and most obvious decrease, consistent with our previous studies. , The heart rate of the M-group increased from the third week and peaked at the fifth week, before returning to the initial level at the end of the exposure, which may be due to the body’s ability to repair reversible damage and functional recovery. , There were no significant differences in heart rate among the low dosage groups. However, both the Pb­(Ac) 2 -group and H 2 -group showed significant differences from the C-group in the last week of exposure ( p < 0.0001 and p = 0.0075, respectively), suggesting that PM 2.5 -Pb can damage the cardiovascular system and cause an abnormal heart rate .…”

“…The Pb(Ac) 2 -group showed the earliest and most obvious decrease, consistent with our previous studies. 15 , 44 The heart rate of the M-group increased from the third week and peaked at the fifth week, before returning to the initial level at the end of the exposure, which may be due to the body’s ability to repair reversible damage and functional recovery. 45 , 46 There were no significant differences in heart rate among the low dosage groups.…”

Assessing the Impact of PM2.5-Bound Arsenic on Cardiovascular Risk among Workers in a Non-ferrous Metal Smelting Area: Insights from Chemical Speciation and Bioavailability

“…The cardiopulmonary function of mice was assessed using the ejection fraction (EF) and fractional shortening (FS) methods (Figure B). The C group had greater EF and FS values than those of the M, H, and Na 2 HAsO 4 groups (EF: p= 0.0144, 0.0022, 0.0003 and 0.0016, respectively; FS: p= 0.0094, 0.0018, 0.0004 and 0.0015, respectively), with the levels of the C group very near to normal levels from our previous work . In conclusion, our results indicated that chronic exposure to excessive As could worsen cardiac dysfunction.…”

“…The C group had greater EF and FS values than those of the M, H, and Na 2 HAsO 4 groups (EF: p= 0.0144, 0.0022, 0.0003 and 0.0016, respectively; FS: p= 0.0094, 0.0018, 0.0004 and 0.0015, respectively), with the levels of the C group very near to normal levels from our previous work. 49 In conclusion, our results indicated that chronic exposure to excessive As could worsen cardiac dysfunction. Compared with the C group, the H&E staining results of mice in the H 5 and Na 2 HAsO 4 groups showed more inflammatory cell infiltration ( Figure 4 C).…”