DEHP exposure elevated cardiovascular risk in obese mice by disturbing the arachidonic acid metabolism of gut microbiota

Chai, Xuyang; Wen, Luyao; He, Xiaochong; Yue, Jingxian; Wu, Jian‐Lin; Chen, Xin; Cai, Zongwei; Qi, Zenghua

doi:10.1016/j.scitotenv.2023.162615

Cited by 15 publications

(9 citation statements)

References 53 publications

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“…Elevated levels of IL-6 and TNF-α exacerbate T2D by promoting insulin resistance, impairing β-cell function, and triggering cell apoptosis. Faecalibaculum , as proinflammatory bacteria, may impair the gut barrier, contributing to the high serum LPS, TNF-α, and IL-6 expression . It might be one reason why the model group showed a significant increase in high proinflammatory cytokine levels compared to the control group, as Faecalibaculum ’s abundance increased in the former (Figure E–F and Figure I).…”

Section: Discussionmentioning

confidence: 96%

“…Faecalibaculum, as proinflammatory bacteria, may impair the gut barrier, contributing to the high serum LPS, TNF-α, 49 and IL-6 expression. 36 It might be one reason why the model group showed a significant increase in high proinflammatory cytokine levels compared to the control group, as Faecalibaculum's abundance increased in the former (Figure 4E−F and Figure 5I). The administration of probiotics decreased its abundance in T2D mice, thereby evidently (p < 0.05) suppressing IL-6 and TNF-α secretions.…”

Section: ■ Discussionmentioning

confidence: 97%

“…35 Faecalibaculum has been shown to be positively associated with serum lipid levels of TC and TG. 36 The introduction of all four probiotics decreased its abundance in T2D mice, which might be one reason for their potential hypolipidemic activity.…”

Section: ■ Discussionmentioning

confidence: 99%

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Amelioration of Type 2 Diabetes Using Four Strains of Lactobacillus Probiotics: Effects on Gut Microbiota Reconstitution-Mediated Regulation of Glucose Homeostasis, Inflammation, and Oxidative Stress in Mice

Song,

Xue,

Zhang

et al. 2023

J. Agric. Food Chem.

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Section: Discussionmentioning

confidence: 96%

Section: ■ Discussionmentioning

confidence: 97%

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Amelioration of Type 2 Diabetes Using Four Strains of Lactobacillus Probiotics: Effects on Gut Microbiota Reconstitution-Mediated Regulation of Glucose Homeostasis, Inflammation, and Oxidative Stress in Mice

Song,

Xue,

Zhang

et al. 2023

J. Agric. Food Chem.

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“…However, OPZCL ultimately improved the intestinal homeostasis. It has been found that exposure of mice to DEHP or BPA (plasticizer) increased the abundance of Lactobacillus , which reduces intestinal absorption by promoting the excretion of DEHP and BPA [ 55 , 56 , 57 ]. Therefore, it was hypothesized that the increase in Lactobacillus after DEHP exposure was due to an increase in DEHP-degrading bacteria.…”

Section: Discussionmentioning

confidence: 99%

Oyster Peptide-Zinc Complex Ameliorates Di-(2-ethylhexyl) Phthalate-Induced Testis Injury in Male Mice and Improving Gut Microbiota

Lu,

Huang,

Chen

et al. 2023

Foods

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Di-(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer, which can cause damage to male reproductive organs, especially the atrophy of the testis. Meanwhile, DEHP can also lead to a decrease in testicular zinc content, but the role of zinc remains unclear. This study aims to prepare oyster peptide-zinc complex (OPZC) to alleviate DEHP-induced reproductive damage in mice. OPZC was successfully obtained through electron microscopy, X-ray diffraction, and thermogravimetric analysis, with stable structure and high water-solubility. Low dose oyster peptide-zinc complex (OPZCL) significantly reduced the reproductive damage caused by DEHP in mice. Further research had shown that OPZCL restored the content of serum hormones and the activity of oxidative stress kinases to normal, while also normalizing testicular zinc and selenium levels. In addition, it also recovered the disorder of gut microbiota, reduced the proportion of Bacteroides, increased the abundance of Ligilactobacillus, and restored the proportion of Acidobacterota, Chloroflexi, and Proteobacteria. Therefore, OPZCL can relieve the reproductive damage caused by DEHP in mice by restoring testicular zinc homeostasis and the composition of intestinal microbiota, indicating that OPZCL has a potential protective effect on male reproductive health.

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“…In a mouse multi-omics study, prenatal exposure to low-dose BPA altered the expression of hepatic genes implicated in oxidative phosphorylation, fatty acid metabolism and PPAR signaling and impacted intestinal bacterial diversity in an age- and gender-dependent fashion [ 127 ]. Exposure to phthalate esters such as DEHP elevated cardiovascular risk in obese mice by dysregulating the arachidonic acid metabolism of intestinal flora [ 128 ], while prolonged exposure increased weight and liver lipogenesis in mice by inducing the uptake of fatty acids and dysregulating the metabolism of phospholipids and choline [ 129 ].…”

Section: Mechanisms Linking Endocrine Disruptors To Obesitymentioning

confidence: 99%

The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies

Dalamaga,

Kounatidis,

Tsilingiris

et al. 2024

IJMS

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Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides the type of diet, calorie intake and the lack of physical exercise, recent data have highlighted a possible association between endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates and their analogs, and obesity. EDCs represent a heterogeneous group of chemicals that may influence the hormonal regulation of body mass and adipose tissue morphology. Based on the available data from mechanistic, animal and epidemiological studies including meta-analyses, the weight of evidence points towards the contribution of EDCs to the development of obesity, associated disorders and obesity-related adipose tissue dysfunction by (1) impacting adipogenesis; (2) modulating epigenetic pathways during development, enhancing susceptibility to obesity; (3) influencing neuroendocrine signals responsible for appetite and satiety; (4) promoting a proinflammatory milieu in adipose tissue and inducing a state of chronic subclinical inflammation; (5) dysregulating gut microbiome and immune homeostasis; and (6) inducing dysfunction in thermogenic adipose tissue. Critical periods of exposure to obesogenic EDCs are the prenatal, neonatal, pubertal and reproductive periods. Interestingly, EDCs even at low doses may promote epigenetic transgenerational inheritance of adult obesity in subsequent generations. The aim of this review is to summarize the available evidence on the role of obesogenic EDCs, specifically BPA and phthalate plasticizers, in the development of obesity, taking into account in vitro, animal and epidemiologic studies; discuss mechanisms linking EDCs to obesity; analyze the effects of EDCs on obesity in critical chronic periods of exposure; and present interesting perspectives, challenges and preventive measures in this research area.

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DEHP exposure elevated cardiovascular risk in obese mice by disturbing the arachidonic acid metabolism of gut microbiota

Cited by 15 publications

References 53 publications

Amelioration of Type 2 Diabetes Using Four Strains of Lactobacillus Probiotics: Effects on Gut Microbiota Reconstitution-Mediated Regulation of Glucose Homeostasis, Inflammation, and Oxidative Stress in Mice

Amelioration of Type 2 Diabetes Using Four Strains of Lactobacillus Probiotics: Effects on Gut Microbiota Reconstitution-Mediated Regulation of Glucose Homeostasis, Inflammation, and Oxidative Stress in Mice

Oyster Peptide-Zinc Complex Ameliorates Di-(2-ethylhexyl) Phthalate-Induced Testis Injury in Male Mice and Improving Gut Microbiota

The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies

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