Amelioration of Type 2 Diabetes Using Four Strains of Lactobacillus Probiotics: Effects on Gut Microbiota Reconstitution-Mediated Regulation of Glucose Homeostasis, Inflammation, and Oxidative Stress in Mice

Valine induces inflammation and enhanced adipogenesis in lean mice by multi-omics analysis

“…Feeding Bacteroides dorei and vulgatus to mice improved BAT BCAA catabolism, decreased circulating BCAA levels and body weight gain (44). Moreover, Bacteroides could be used as probiotics for treating aberrant metabolism, which is currently under active research (44)(45)(46). We found here that Bacteroides decreased in cecum, which could be related to the detrimental effect of valine on lipid metabolism in hepatic and adipose tissues.…”

Latilactobacillus sakei QC9 alleviates hyperglycaemia in high-fat diet and streptozotocin-induced type 2 diabetes mellitus mice via the microbiota–gut–liver axis

“…42 Although a number of antidiabetic drugs are available, long-term use can lead to side effects. 43 Numerous in vitro research studies and in vivo studies in animals have proved that probiotics, especially lactic acid bacteria, have great potential and good prospects in the treatment and prevention of T2DM, 44,45 but the specific mechanism of probiotics in T2DM is not yet fully understood. Therefore, the continuous exploration and identification of new lactic acid bacteria with hypoglycemic effects is of clinical significance, and further clarification of their mechanism will hopefully provide new ideas and opportunities for the prevention and treatment of T2DM.…”

“…Oxidative stress is therefore also considered to be one of the factors in the onset and development of diabetes. 45,49 GSH-Px, CAT, and SOD are the primary antioxidant enzymes that defend our body against harmful ROS. 60 MDA is a marker of oxidative stress and is the product of lipid peroxidation.…”