The Protective Effects of Syzygium aromaticum Essential Oil Extract against Methotrexate Induced Hepatic and Renal Toxicity in Rats

Al-azem, Duaa Abd; Al-Derawi, Karim H.; Al-Saadi, Sahar A. A. Malik

doi:10.22207/jpam.13.1.57

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…Moreover, the efficacy of EOs on poultry and swine production have been identified and reviewed [18,19,20]. The cellular protective effects of EOs against drugs or xenobiotics are also described in the literature [21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

Essential Oils as a Feed Additives: Pharmacokinetics and Potential Toxicity in Monogastric Animals

Horký

Skaličková

Šmerková

et al. 2019

Animals

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Essential oils (EOs) are now a hot topic in finding modern substitutes for antibiotics. Many studies have shown positive results and confirmed their high antibacterial activity both in vitro and in vivo. Deservedly, there is an attempt to use EOs as a substitute for antibiotics, which are currently limited by legislation in animal breeding. Given the potential of EOs, studies on their fate in the body need to be summarized. The content of EO’s active substances varies depending on growing conditions and consequently on processing and storage. Their content also changes dynamically during the passage through the gastrointestinal tract and their effective concentration can be noticeably diluted at their place of action (small intestine and colon). Based on the solubility of the individual EO’s active substances, they are eliminated from the body at different rates. Despite a strong antimicrobial effect, some oils can be toxic to the body and cause damage to the liver, kidneys, or gastrointestinal tissues. Reproductive toxicity has been reported for Origanum vulgare and Mentha arvensis. Several publications also address the effect on the genome. It has been observed that EOs can show both genoprotective effects (Syzygium aromaticum) and genotoxicity, as is the case of Cinnamomum camphor. This review shows that although oils are mainly studied as promising antimicrobials, it is also important to assess animal safety.

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Section: Introductionmentioning

confidence: 99%

Essential Oils as a Feed Additives: Pharmacokinetics and Potential Toxicity in Monogastric Animals

Horký

Skaličková

Šmerková

et al. 2019

Animals

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“…To find the protecting impact of S. aromaticum against ethotrexateinduced liver and kidney nephrotoxicity in rats, Al-Azem et al found that rats treated by methotrexate showed significant histopathological changes in renal tissues like degeneration, inflammatory cell infiltration, necrosis, and hemorrhage. While alteration of kidney tissues was less observed in rats treated with methotrexate and essential clove oil (16).…”

Section: Discussionmentioning

confidence: 81%

Ameliorative impact of hydroalcoholic extract of Clove buds (Syzygium aromaticum) on contrast-induced acute kidney injury; an experimental histopathological study

et al. 2019

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Introduction: The administration of iodinated contrast medium is extensive in various imaging techniques including coronary angiography. Objectives: The present investigation was designed to examine the ameliorative effect of clove buds (Syzygium aromaticum) on contrast-induced acute kidney injury (CI-AKI) in rats Materials and Methods: Forty male Wistar rats with a mean body weight of 200-250 g were studied. Rats randomly assigned into four groups, 10 rats for each; Group 1; normal rats (control group; sham group); they did not receive any drugs. Group 2; rats were received 10 mL/kg as a single dose of iodixanol (contrast media) by intravenous (IV) injection. Group 3; rats received 10 mg/kg clove by intraperitoneal (IP) injection for three days, while in day forth, they received a single dose of iodixanol (10 mL/kg). Group 4; rats of this group first received a single dose of iodixanol (10 mL/ kg). Then rats treated by clove (10 mg/kg) by intraperitoneal (IP) injection for three days (days 2, 3 and 4th). Kidney sections were examined for degeneration, flattening, and necrosis of renal tubular cells and also dilatation of tubular lumen. Results: We found a significant difference between groups regarding the sum of injury (degeneration, flattening, necrosis and dilatation). A significant difference in types of injury (degeneration, flattening, necrosis and dilatation) among the groups (P=0.001) was seen too. We detected a significant difference between groups II (contrast media) and III (rats pretreated by clove; P<0.001). Accordingly, we detected a significant difference between groups II (contrast media) and IV (rats post-pone treated by Clove buds; P<0.001) too. There was not a significant difference between groups of III and IV (P> 0.05). Conclusion: In this animal study, we found that post-pone treatment of clove was as effective as pretreatment to mitigate the injury induced by contrast media.

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“…EOs are commonly associated with hepatotoxicity, nephrotoxicity, changes in the blood vessels and oxidative stress that occur as a result of acute intoxication [ 184 ]. For example, a study focusing on the toxicity of an EO obtained from Syzygium aromaticum (containing mainly eugenol and caryophyllene) confirmed its negative effect on rats after intraperitoneal injection (0.125 mg/kg), resulting in changes of kidney tissue [ 185 ]. Some EOs have also been associated with toxicity to reproductive system.…”

Section: Alternatives To Conventional Antibiotics Used To Treat Bacterial Skin Infections In Animalsmentioning

confidence: 99%

Bacterial Skin Infections in Livestock and Plant-Based Alternatives to Their Antibiotic Treatment

Malá

Laloučková

Skřivanová

2021

Animals

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Due to its large surface area, the skin is susceptible to various injuries, possibly accompanied by the entrance of infective agents into the body. Commensal organisms that constitute the skin microbiota play important roles in the orchestration of cutaneous homeostasis and immune competence. The opportunistic pathogen Staphylococcus aureus is present as part of the normal biota of the skin and mucous membranes in both humans and animals, but can cause disease when it invades the body either due to trauma or because of the impaired immune response of the host. Colonization of livestock skin by S. aureus is a precursor for majority of bacterial skin infections, which range from boils to sepsis, with the best-characterized being bovine mastitis. Antibiotic treatment of these infections can contribute to the promotion of resistant bacterial strains and even to multidrug resistance. The development of antibiotic resistance to currently available antibiotics is a worldwide problem. Considering the increasing ability of bacteria to effectively resist antibacterial agents, it is important to reduce the livestock consumption of antibiotics to preserve antibiotic effectiveness in the future. Plants are recognized as sources of various bioactive substances, including antibacterial activity towards clinically important microorganisms. This review provides an overview of the current knowledge on the major groups of phytochemicals with antibacterial activity and their modes of action. It also provides a list of currently known and used plant species aimed at treating or preventing bacterial skin infections in livestock.

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The Protective Effects of Syzygium aromaticum Essential Oil Extract against Methotrexate Induced Hepatic and Renal Toxicity in Rats

Cited by 8 publications

References 25 publications

Essential Oils as a Feed Additives: Pharmacokinetics and Potential Toxicity in Monogastric Animals

Essential Oils as a Feed Additives: Pharmacokinetics and Potential Toxicity in Monogastric Animals

Ameliorative impact of hydroalcoholic extract of Clove buds (Syzygium aromaticum) on contrast-induced acute kidney injury; an experimental histopathological study

Bacterial Skin Infections in Livestock and Plant-Based Alternatives to Their Antibiotic Treatment

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