The Protective Effects of Shen-Fu Injection on Experimental Acute Pancreatitis in a Rat Model

Huang, Lei; Cao, Jun

doi:10.1155/2014/248786

Cited by 17 publications

(13 citation statements)

References 24 publications

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“…Furthermore, SB treatment increased beta‐cell proliferation and improved glucose homeostasis . l ‐Arg treatment significantly increases the oxidative and nitrosative stress, which leads to inflammatory response and finally causes the acinar cell damage . SB treatment decreased the oxidative and nitrosative stress, histological alterations such as acinar cell atrophy, vacuolization, inflammatory cells infiltration, and fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Sodium Butyrate Ameliorates l‐Arginine‐Induced Pancreatitis and Associated Fibrosis in Wistar Rat: Role of Inflammation and Nitrosative Stress

Kanika

Khan

Jena

2015

J Biochem & Molecular Tox

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Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is a short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of SB against L-arginine (L-Arg)-induced pancreatic fibrosis in Wistar rats. Pancreatic fibrosis was induced by twice intraperitoneal (i.p.) injections of 20% L-Arg (250 mg/100 g) at 2-h interval on day 1, 4, 7, and 10, whereas SB (800 mg/kg/day) was administrated for 10 days. At the end of the study, biochemical estimations, histological alterations, DNA damage, and the expression of various proteins were evaluated. Posttreatment of SB decreased L-Arg-induced oxidative and nitrosative stress, DNA damage, histological alterations, and fibrosis. Interestingly, posttreatment of SB significantly decreased the expression of α-smooth muscle actin, interleukin-1β, inducible nitric oxide synthase, and 3-nitrotyrosine. The present study demonstrated that posttreatment of SB alleviates L-Arg-induced pancreatic damage and fibrosis in rat.

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Section: Discussionmentioning

confidence: 99%

Sodium Butyrate Ameliorates l‐Arginine‐Induced Pancreatitis and Associated Fibrosis in Wistar Rat: Role of Inflammation and Nitrosative Stress

Kanika

Khan

Jena

2015

J Biochem & Molecular Tox

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“…Intestinal I/R not only leads to severe intestine damage but also induced subsequent destruction of remote organs including liver, lung, and kidney as well [1–3]. Liver is the most vulnerable organ after intestinal I/R because of the theory that liver and intestine share the anatomical common pathway such as coupled vasculature [4].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model

Jing

Yao

et al. 2014

Oxidative Medicine and Cellular Longevity

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Objective. In this study, we investigated the protective effect and mechanism of curcumin on a rat model of intestinal ischemia/reperfusion (I/R), which induces an acute liver lesion. Methods. Curcumin was injected into rats in the curcumin groups through left femoral vein. The same volume of vehicle (0.9% normal saline) was injected into sham and I/R groups. Blood and liver tissue were gathered for serological and histopathological determination. Results. Intestinal I/R led to severe liver injury manifested as a significant increase in serum AST and ALT levels; all of those were reduced by treatment with curcumin. Simultaneously, the activity of SOD in liver decreased after intestinal I/R, which was increased by curcumin treatment. On the other hand, curcumin reduced MPO activity of liver tissue, as well as serum IL-6 and TNF-α levels observably. This is in parallel with the decreased level of liver intercellular cell adhesion molecule-1 (ICAM-1) and nuclear factor-κB (NF-κB) expression. Conclusion. Our findings suggest that curcumin treatment attenuates liver lesion induced by intestinal I/R, attributable to the antioxidative and anti-inflammatory effect via inhibition of the NF-κB pathway.

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“…Increased lipid peroxidation in bile or pancreas tissue have been reported in humans with AP (Park et al, 2003). Increasing MDA levels and decreasing GSH levels reflect tissue damage in AP (Guleken et al, 2017;Huang & Cao, 2014;Mirmalek et al, 2016). The model verifies tissue damage, not only histologically but also biochemically, with GSH depletion and MDA elevation.…”

Section: Discussionmentioning

confidence: 98%

Myrtus communisleaf extract protects against cerulein‐induced acute pancreatitis in rats

et al. 2019

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In this study, the aim was to examine the potential protective effects of Myrtus communis subsp. communis leaf ethanol extract (MC) treatment against acute pancreatitis (AP) in rats. Thirty‐two rats were grouped as the saline‐pretreated control (C), MC‐pretreated control (MC), saline‐pretreated AP (AP), and MC‐pretreated AP (MC + AP) groups. To induce AP, cerulein was administered (50 µg/kg) two times. The rats were given MC for 14 days before cerulein injection. Six hours after the final cerulein injection, the rats were sacrificed. Pancreatic damage was associated with an increase in the serum activity of lipase and amylase, the pancreatic activity of myeloperoxidase, and the pancreatic level of malondialdehyde, interleukin‐1β, and interleukin‐6. AP also led to a decrease in the pancreatic level of anti‐inflammatory interleukin‐10 and glutathione. Pretreatment with MC before the induction of AP significantly reduced the pancreatic damage observed during the histological examination as well as reversed the biochemical changes evoked by AP. Practical applications Acute pancreatitis is characterized by high mortality (average about 5%; severe cases may reach about 30%). The current treatment for acute pancreatitis is mainly symptomatic. The introduction of herbal drugs may lead to the development of a new strategy in the treatment of this disease. This study revealed that MC reduced pancreatic injury by decreasing pro‐inflammatory cytokines, increasing antioxidant capacity and anti‐inflammatory cytokine, IL‐10. To the authors’ knowledge, this research is the first report showing that MC inhibits the development of AP. This observation suggests that MC may be useful in the prevention and the treatment of AP in clinical settings.

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The Protective Effects of Shen-Fu Injection on Experimental Acute Pancreatitis in a Rat Model

Cited by 17 publications

References 24 publications

Sodium Butyrate Ameliorates l‐Arginine‐Induced Pancreatitis and Associated Fibrosis in Wistar Rat: Role of Inflammation and Nitrosative Stress

Sodium Butyrate Ameliorates l‐Arginine‐Induced Pancreatitis and Associated Fibrosis in Wistar Rat: Role of Inflammation and Nitrosative Stress

The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model

Myrtus communisleaf extract protects against cerulein‐induced acute pancreatitis in rats

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