The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-<i>κ</i>B in a Rat Model

Jing, Huirong; Yao, Jihong; Li, Yang; Hu, Xiaowei; Shao, Huizhu; Shen, Gang; Jy, Pan; Tian, Xiaofeng

doi:10.1155/2014/191624

Cited by 39 publications

(42 citation statements)

References 20 publications

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“…This may be due to the ability of curcumin to combat oxidative stress by scavenging free radicals such as superoxide anion, hydroxyl radical, nitrogen dioxide, nitric oxide (Kakkar, Muppu, Chopra, & Kaur, ). The results are in agreement with previous reports in the literature where curcumin treatment has been shown to upregulate the activity of antioxidant enzymes (Fan et al, ; Guzel, Kanter, Guzel, Yucel, & Erboga, ; Yucel, Kanter, Pergel, Erboga, & Guzel, ). Furthermore and regarding the disparition of fluorescence and the decrease in the tissue level of CDC during cold preservation suggests that CDC may be utilized in antioxidant reactions, the main degradation product of curcumin being vanillin and ferulic acid derivatives, both antioxidants (Shen & Ji, ).…”

Section: Discussionsupporting

confidence: 93%

Hepatocellular uptake of cyclodextrin‐complexed curcumin during liver preservation: A feasibility study

Saidi

Meurisse

Jochmans

et al. 2017

Biopharm & Drug Disp

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The increasing demand for donor organs and the decreasing organ quality is prompting research toward new methods to reduce ischemia reperfusion injury (IRI). Several strategies have been proposed to protect preserved organs from this injury. Before curcumin/dextrin complex (CDC), a potent antioxidant and anti-inflammatory agent, can be used clinically we need to better understand the intracellular uptake under hypothermic conditions on a rat model of liver donation after circulatory death (DCD) and brain death (DBD). To be able to use the fluorescence of CDC for quantification the stability of CDC in different preservation solutions at 4°C or 37°C was investigated. Livers from Wistar rats were procured after being flushed-out through the portal vein using CDC-enriched preservation solutions and stored at 4°C for variable periods. The CDC signal was stable in different preservation solutions over a period of 4 h and allowed the rapid and lasting uptake of curcumin into cells. After 4 h of preservation, CDC was no longer visible microscopically, and HPLC analysis showed very low to non-detectable tissue levels of CDC, proving metabolization during preservation. However, the distribution of CDC was not affected by warm ischemia damage (p = 0.278) nor by flushing the livers before or after 4 h of cold storage and without a warm preflush. Finally, curcumin reduced oxidative stress, lowered histological injury and did not change gene expression after WI/cold storage. Therefore, the use of CDC flush solution for the initial organ flush can offer a promising approach to the enhancement of liver preservation and the maintenance of its quality.

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Section: Discussionsupporting

confidence: 93%

Hepatocellular uptake of cyclodextrin‐complexed curcumin during liver preservation: A feasibility study

Saidi

Meurisse

Jochmans

et al. 2017

Biopharm & Drug Disp

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“…The study protocol and experiments were conducted according to the guidelines of the Institutional Animal Care and Use Committee of Dalian Medical University and were approved by the Institutional Ethics Committee of Dalian Medical University. The intestinal I/R injury rat model was induced as previously described2728. Briefly, rats were fasted for 12 h with free access to tap water before surgery.…”

Section: Methodsmentioning

confidence: 99%

Protective effects of ginsenoside Rg1 on intestinal ischemia/reperfusion injury-induced oxidative stress and apoptosis via activation of the Wnt/β-catenin pathway

Guo

Che

et al. 2016

Sci Rep

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Ginsenoside Rg1 (Rg1) is one of the major bioactive ingredients in Panax ginseng, and it attenuates inflammation and apoptosis. The aims of our study were to explore the potential of Rg1 for the treatment of intestinal I/R injury and to determine whether the protective effects of Rg1 were exerted through the Wnt/β-catenin signaling pathway. In this study, Rg1 treatment ameliorated inflammatory factors, ROS and apoptosis that were induced by intestinal I/R injury. Cell viability was increased and cell apoptosis was decreased with Rg1 pretreatment following hypoxia/reoxygenation (H/R) in the in vitro study. Rg1 activated the Wnt/β-catenin signaling pathway in both the in vivo and in vitro models, and in the in vitro study, the activation was blocked by DKK1. Our study provides evidence that pretreatment with Rg1 significantly reduces ROS and apoptosis induced by intestinal I/R injury via activation of the Wnt/β-catenin pathway. Taken together, our results suggest that Rg1 could exert its therapeutic effects on intestinal I/R injury through the Wnt/β-catenin signaling pathway and provide a novel treatment modality for intestinal I/R injury.

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“…6). Fan et al (2014) and Yu et al (2011) suggested that curcumin decreased serum AST and ALT levels in rat and mouse livers. Bajda et al (2014) observed that the activities of these enzymes were lower in the hemolymph of bees treated with amphotericin B.…”

Section: Curcumin Extend the Apian Resistance And Life Span Resultsmentioning

confidence: 99%

Curcumin Stimulates Biochemical Mechanisms of Apis Mellifera Resistance and Extends the Apian Life-Span

Strachecka

Olszewski

Paleolog

2015

Journal of Apicultural Science

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a b s t r a c t We examined the influence of curcumin-supplemented feeding on worker lifespan, Nosema resistance, key enzyme activities, metabolic compound concentrations and percentage of the global dna methylation. two worker groups (Apis mellifera) were set up: 1) control group; workers were fed ad libitum with sucrose syrup; 2) workers were fed with the syrup with the addition of curcumin. dead workers were removed every two days and the Nosema spp. infection levels were assessed. hemolymph was taken from living workers for biochemical analyses. the global dna methylation level was analysed using dna from worker heads and thoraces. the bees that consumed curcumin lived longer and were less infested with Nosema spp. the curcumin-treated workers had higher concentrations of proteins, non-enzymatic biomarkers (triglycerides, glucose, cholesterol, mg 2+ and Ca 2+ ), uric acid and creatinine, as well as elevated activities of antioxidant enzymes (sod, Gpx, Cat, Gst), neutral proteases, protease inhibitors, enzymatic biomarkers (ast, alt, alp). the concentrations of albumin and urea, and the activities of acidic and alkaline proteases were higher in the control group. Curcumin decreased global dna methylation levels especially in older bees in which the natural, age-related level increase was observed. most of the parameters increased over the apian youth and adulthood, and decreased in older bees. the decrease was markedly delayed in the bees fed with curcumin. Curcumin appeared to be an unexpectedly effective natural bio-stimulator, improving apian health and vitality. this multifactorial effect is caused by the activation of many biochemical processes involved in the formation of apian resistance.

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The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-κB in a Rat Model

Cited by 39 publications

References 20 publications

Hepatocellular uptake of cyclodextrin‐complexed curcumin during liver preservation: A feasibility study

Hepatocellular uptake of cyclodextrin‐complexed curcumin during liver preservation: A feasibility study

Protective effects of ginsenoside Rg1 on intestinal ischemia/reperfusion injury-induced oxidative stress and apoptosis via activation of the Wnt/β-catenin pathway

Curcumin Stimulates Biochemical Mechanisms of Apis Mellifera Resistance and Extends the Apian Life-Span

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