The protective effects of rosmarinic acid on ethanol-induced gastritis in male rats: antioxidant defense enhancement

Heidari, Fatemeh; Komeili-Movahhed, Tahereh; Hamidizad, Zeinab; Moslehi, Azam

doi:10.4103/1735-5362.314829

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…Although gastritis caused by alcohol is mediated by increased levels of inflammatory factors, the use of anti-inflammatory drugs may increase gastric mucosal damage or cause kidney disease [ 20 ]. In addition, oxidative stress and accompanied inflammatory responses promote mucosal damage in the case of alcoholic gastritis [ 21 ]. Recent research has suggested that natural products are safe and effective gastrointestinal protectants [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model

Kim¹,

Lee²,

Beak³

et al. 2023

Phys Act Nutr

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[Purpose] Excessive exercise causes various gastric dysfunction. Gastritis is common among athletes who perform high-intensity training. Gastritis is a digestive disease involving mucosal damage caused by inflammatory reactions and oxidative stress. In this study, the effects of a complex natural extract on gastric mucosal damage and the expression of inflammatory factors were evaluated in an animal model of alcohol-induced gastritis.[Methods] A mixed herbal medicine (Ma-al-gan; MAG) was prepared with four natural products (Curcumae longae Rhizoma, Schisandrae chinensis Fructus, Artemisiae scopariae herba, and Gardeniae Fructus) identified by a systemic analysis using the Traditional Chinese Medicine Systems Pharmacology platform. The effects of MAG on alcohol-induced gastric damage were evaluated.[Results] MAG (10–100 μg/mL) significantly reduced the mRNA and protein levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells. MAG (500 mg/kg/d) effectively prevented alcohol-induced gastric mucosal injury in vivo.[Conclusion] MAG regulates inflammatory signals and oxidative stress and is a potential herbal medicine for gastric disorders.

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Section: Discussionmentioning

confidence: 99%

Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model

Kim¹,

Lee²,

Beak³

et al. 2023

Phys Act Nutr

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show abstract

“…Based on the findings that oxidative stress and inflammation are major players in the pathogenesis of gastritis, several natural products that possess antioxidant and anti-inflammatory properties have been investigated for their potential protective and therapeutic effect against ethanol-induced gastritis, such as rosmarinic acid, red ginseng, curcumin, and resveratrol, and various polyphenolic compounds [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Effect of Quercus infectoria Olivier Galls on Ethanol-Induced Gastritis in Rats

Eltahir

2024

Cureus

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One of the common inflammatory disorders that substantially affects the stomach and its mucosa is gastritis. It can be induced by non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, alcohol, Helicobacter pylori infection, and stress. These factors affect cellular regeneration, mucus production, and bicarbonate secretion, resulting finally in inflammation and ulceration. Ethanol-induced gastritis is one of the commonly used models for studying the pathology of gastritis and investigating the effect of drugs in managing the disease. Several drugs, such as proton pump inhibitors (PPIs), are available to control and correct the pathological signs of gastritis; however, the side effects of such drugs represent an obstacle to their applications in many cases. Quercus infectoria (QI) Olivier galls are formed as a pathological response to wasp insults to the tree. They are rich in several bioactive molecules, e.g., gallotannins that have been shown to be effective in several inflammatory conditions due to their antioxidant and anti-inflammatory potentials. In this study, we aimed to evaluate the therapeutic potential of QI gall extract (QIGE) in treating ethanol-induced gastritis in rats. To test this, 20 adult male Swiss rats were divided into four groups: healthy control, ethanol-treated (80% in water, 5 ml/kg, per oral gavage), ethanol + omeprazole (20 mg/kg, per oral gavage), and ethanol + QIGE (300 mg/kg, per oral gavage). QIGE was administered for seven days before ethanol administration, which took place three hours after the last QIGE dose. Three hours after ethanol intake, animals were euthanized, gastric content was collected, and stomach tissue was examined for macroscopic changes and then fixed to be further utilized for histological assessment by hematoxylin and eosin (H&E), periodic acid-Schiff (PAS), and Masson’s trichrome staining. Ethanol treatment significantly decreased gastric pH and increased gastric acidity compared to healthy control. It also induced clear morphological and histological damage and ulceration, depleted mucus on the gastric epithelium, and induced edema and collagen deposition in gastric submucosa. The QIGE treatment ameliorated the changes in gastric pH and total acidity. It also protected stomach tissue from ethanol-induced ulceration, histopathological changes, edema, and collagen deposition. The protective effects of QIGE were comparable to those of omeprazole. In conclusion, QI gall extract possesses a promising gastroprotective effect against ethanol-induced gastritis.

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Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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The protective effects of rosmarinic acid on ethanol-induced gastritis in male rats: antioxidant defense enhancement

Cited by 7 publications

References 35 publications

Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model

Feasibility of mixed herbal medicine for improving gastric function in an alcohol-induced gastritis model

Gastroprotective Effect of Quercus infectoria Olivier Galls on Ethanol-Induced Gastritis in Rats

Biomedical features and therapeutic potential of rosmarinic acid

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