The protective effects of ketamine and propofol in obstructive jaundice: an experimental study

Yıldız, Hüseyin Bekir; Çoşkuner, İsmail; Bülbüloğlu, Ertan; Sılay, Emin; Eb, Kurutas; Doğan, Zafer; Kantarçeken, Bülent; Öksüz, Hüseyın; Şenoğlu, Nimet; Mf, Yuzbasioglu; Cetinkaya, Aytac; Çıralık, Harun

doi:10.4149/bll_2012_034

Cited by 4 publications

(5 citation statements)

References 39 publications

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“…Neutrophil migration and toxic biliary products start the generation of oxygen free radicals, thus unbalancing the antioxidant status in the liver. Antioxidant defenses, as demonstrated by GSH, catalase and SOD, are found to be decreased while lipid peroxidation, as demonstrated by MDA levels, is found to be increased in rat models with OJ (7,18,19). There have been studies suggesting that LA reduced MDA levels and increased antioxidant levels such as GSH and SOD in hepatic pathologies (20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 96%

The effect of alpha‑lipoic acid on oxidative parameters and liver injury in rats with obstructive jaundice

Atalay¹,

Özdemir²,

Tur³

et al. 2019

BLL

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INTRODUCTION: The aim of this study is to investigate the effects of obstructive jaundice on the liver and effectivity of alpha-lipoic acid on liver damage and oxidative stress. MATERIALS AND METHODS: Thirty-six male Sprague-Dawley rats were divided into 3 groups per 12 animals, namely into Group I (control group): the bile duct was only mobilized by laparotomy, Group II (bile duct ligation group-BDL): the common bile duct was closed with clips and OJ was caused after laparotomy, and Group III (bile duct ligation and alpha-lipoic acid group-BDL+LA): after closing the common bile duct, LA was administered in an intramuscular dose of 50 mg/kg for 10 days. On the 10th day, malondialdehyde, glutathione and superoxide dismutase levels were measured in liver and histopathological evaluation was performed. RESULTS: AST (U/L)/ALT(U/L) in groups I, II and III were 155.33/51.83, 445.28/165.89, 380.78/173.33, respectively (p < 0.005). Superoxide dismutase and glutathione levels were lower in patient groups than in the control group (0.31 μl/g vs 0.36 μl/g; p < 0.05). After the lipoic acid treatment, none of the biochemical markers of liver improved. Only the increase in superoxide dismutase (0.31 μl/g and 0.34 μl/g in groups II and III, respectively) and glutathione levels (0.16 μl/g and 0.22 μl/g in groups II and III, respectively) was statistically signifi cant (p < 0.05). CONCLUSIONS: Histopathological damage was statistically signifi cantly decreased and antioxidant levels were statistically signifi cantly increased after LA treatment (Tab. 1, Fig. 6, Ref. 23).

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Section: Discussionmentioning

confidence: 96%

The effect of alpha‑lipoic acid on oxidative parameters and liver injury in rats with obstructive jaundice

Atalay¹,

Özdemir²,

Tur³

et al. 2019

BLL

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“…Antioxidant defence (as demonstrated by CAT and SOD activities) is diminished and lipid peroxidation (as demonstrated by MDA levels) is increased during extrahepatic OJ in rat models. 17 , 18 Tissue damage associated with OJ may be caused by accelerated generation of hydroxyl radicals. Many clinical observations and experimental studies point to the frequent occurrence of different organ complications in patients with OJ.…”

Section: Discussionmentioning

confidence: 99%

L-carnitine reduces acute lung injury in experimental biliary obstruction

Kaya

Koca

Barut

et al. 2015

SMJ

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Objectives:To investigate the protective effects of L-carnitine (LC) on lungs in an experimental obstructive jaundice (OJ) model.Methods:This was conducted for 2 months between May 2011 and July 2011 at Suleyman Demirel University School of Medicine Experimental and Clinical Research Center, Isparta, Turkey. Thirty-eight Wistar-Albino rats with an average weight of 250-300 g were divided into 3 groups of control, OJ, and OJ + L-carnitine treatment (LCT). L-carnitine was injected intravenously into the tail vein at a dose of 50 mg/kg/day for 10 days to the LCT group. Animals were sacrificed 10 days later. Enzyme levels were measured in the lung tissue; malondialdehyde, myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), catalase, and superoxide dismutase. Tumor necrosis factor-alfa, interleukin 6 (IL-6), IL-8, and C-reactive protein levels were studied in plasma samples. Histopathological changes in the lungs were examined.Results:There was a decreased in GSH-Px, MPO, and IL-8 levels (p<0.05) in the LCT group. The histopathological examination showed that neutrophil leukocyte infiltration and edema formation decreased and destruction of lung parenchyma disappeared following the treatment with LC (p<0.05).Conclusion:L-carnitine has a protective effect against lung damage due to experimental obstructive jaundice, possibly by altering anticytokine and antioxidant activity, and by decreasing the neutrophil migration.

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“…However, excess accumulation of ROS induces a chain of reactions in cardiovascular pathological processes such as hypertension, ischemia/reperfusion injury (20). It has been reported that markers of oxidative stress (such as malondialdehyde, superoxide dismutase and catalase) are affected by ketamine and thiopental to different degrees (21).…”

Section: Discussionmentioning

confidence: 99%

The role of mitochondrial ATP-sensitive potassium channels on cardiovascular effects of thiopental and ketamine in rats

Altunkaynak¹,

Tecder-Ünal²

2015

BLL

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OBJECTIVE: We aimed to investigate whether mitochondrial ATP-sensitive potassium (mitoK ATP) channels play any role on cardiovascular effects of thiopental (TP) or ketamine (K) anesthesia in rats. BACKGROUND: mitoK ATP channels are the end-effectors of cardioprotection induced by some anesthetics. TP and K are the most frequently used anesthetics with their own cardiovascular effects in experimental studies. To the best of our knowledge, there is no study investigating the cardiovascular effects of TP and K associated with mitoK ATP channels. MATERIALS AND METHODS: The experimental groups: TP control, K/Xylazine (X) control, TP+5-hydroxydecanoate (5-HD; mitoK ATP channel blocker) and K/X+5-HD. Mean arterial blood pressure (MABP), heart rate (HR) and standard limb lead II ECG were recorded and arrhythmia parameters were evaluated. RESULTS: Blockage of mitoK ATP channels by 5-HD increased MABP and decreased HR in the TP+5-HD and K/ X+5-HD groups, respectively. 5-HD caused an increase in ventricular ectopic beat (VEB) incidence. Moreover, VEB incidence was signifi cantly different in TP+5-HD (100 %) than K/X+5-HDgroup (66.6 %) and ventricular tachycardia was only seen in TP+5-HD (incidence was 88.3 %). CONCLUSION: mitoK ATP channels play different roles in infl uencing cardiovascular effects of K/X and TP anesthesia in rats. The differences in hemodynamic parameters and arrhythmia scores of these anesthetics should be considered when they are used in an experimental study associated with mitoK ATP channels (Fig. 3, Ref. 35).

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The protective effects of ketamine and propofol in obstructive jaundice: an experimental study

Cited by 4 publications

References 39 publications

The effect of alpha‑lipoic acid on oxidative parameters and liver injury in rats with obstructive jaundice

The effect of alpha‑lipoic acid on oxidative parameters and liver injury in rats with obstructive jaundice

L-carnitine reduces acute lung injury in experimental biliary obstruction

The role of mitochondrial ATP-sensitive potassium channels on cardiovascular effects of thiopental and ketamine in rats

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