The Protective Effect of α-Tocopherol on the Content of Selected Elements in the Calvaria for Exposed Hens to TCDD in the Early Embryonic Period

The Protective Effect of Xanthohumol on the Content of Selected Elements in the Bone Tissue for Exposed Japanese Quails to TCDD

“…The previous reports confirm the need to search for substances that eliminate or reduce the effects of dioxins on the bone tissue [ 4 , 19 , 48 , 50 ].…”

“…Previous experimental studies have proven the adverse effects of dioxins as environmental factors on bone remodeling in the experimental animals, both in developmental and adult age [ 43 ]. It was found that exposure to TCDD led to decrease of bone mechanical strength and caused an increase in density of cortical bone in studied adult rats [ 4 , 19 , 47 , 48 , 49 ].…”

“…That can result in formation of hard tissues with low mineral levels [ 17 , 18 ]. The bones of the cranial vault and long bones differ in their histological structure, which is associated with their slightly various functions [ 4 , 19 , 20 , 21 , 22 ]. The intensity of bone metabolic processes is associated with the availability of transmission of signals—and therefore, with blood flow [ 23 ].…”

Indirect study of the effect of α-tocopherol and acetylsalicylic acid on the mineral composition of bone tissue in the offspring of female rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: long-term observations

“…Owing to the fact that this bone is not exposed to mechanical loads, it provides a good and commonly used experimental model for proper reection of the processes taking place during embryogenesis and postnatal growth. 31,[35][36][37][54][55][56] Aer the birth, the calvaria undergoes an intense process of bone remodeling, which is manifested in our results by a subsequent increase in the calcium content. Increased bone resorption in the rat is associated with the development of the skull which occurs between the 4th and 6th week aer birth.…”

“…It has been shown in recent studies that two well-known substances, a-tocopherol and acetylsalicylic acid (ASA), have properties that can reduce the effects of dioxins poisoning. 3,31,36,38,39 Nowadays, monitoring the constant exposure of humans and animals to dioxins and their inuence on bone mineralization is essential for the prevention of dioxin intoxication and the development of effective pharmacological treatment methods…”