The protective effect of α-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs

Saadat, Saeideh; Mohammadi, Mostafa; Fallahi, Maryam; Keyhanmanesh, ‬Rana; Aslani, Mohammad Reza

doi:10.1007/s12576-015-0367-6

Cited by 25 publications

(21 citation statements)

References 23 publications

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“…NS and its active compounds thymoquinone, nigellone and α-hederin have been investigated in eighteen whole or cellular animal models and one human cellular model related to asthma. NS oil, thymoquinone or α-hederin showed anti-inflammatory and immunomodulatory effects in seven studies (Abbas et al, 2005, Balaha et al, 2012, El Gazzar et al, 2006, Mansour and Tornhamre, 2004, Saadat et al, 2015, Saleh et al, 2012, Shahzad et al, 2009). NS extracts, thymoquinone or α-hederin demonstrated a bronchodilatory or relaxant effect in six studies (Abd El Aziz et al, 2011, Al-Majed et al, 2001, Boskabady et al, 2008, Gilani et al, 2001, Keyhanmanesh et al, 2013, Saadat et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

“…NS oil, thymoquinone or α-hederin showed anti-inflammatory and immunomodulatory effects in seven studies (Abbas et al, 2005, Balaha et al, 2012, El Gazzar et al, 2006, Mansour and Tornhamre, 2004, Saadat et al, 2015, Saleh et al, 2012, Shahzad et al, 2009). NS extracts, thymoquinone or α-hederin demonstrated a bronchodilatory or relaxant effect in six studies (Abd El Aziz et al, 2011, Al-Majed et al, 2001, Boskabady et al, 2008, Gilani et al, 2001, Keyhanmanesh et al, 2013, Saadat et al, 2015). The anti-histaminic effect was shown in four studies used NS oil/aqueous extract, nigellone or α-hederin (Abd El Aziz et al, 2011, Chakravarty, 1993, Saadat et al, 2015, Saleh et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

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Medicinal benefits of Nigella sativa in bronchial asthma: A literature review

Koshak

2017

Saudi Pharmaceutical Journal

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L. (NS) seeds, known as black seed, is a spice and a traditional herbal medicine used in various diseases including bronchial asthma. This review aimed to assess the studies supporting the medicinal use of NS in asthma and to highlight future research priorities. Various medical databases were searched for the effects of NS and its active secondary metabolites in asthma inflammation and outcomes. There were fourteen preclinical studies describing multiple effects of NS in animal or cellular models of asthma including bronchodilation, anti-histaminic, anti-inflammatory, anti-leukotrienes and immunomodulatory effects. Furthermore, seven clinical studies showed improvements in different asthma outcomes including symptoms, pulmonary function and laboratory parameters. However, often these studies are small and used ill-defined preparations. In conclusion, NS could be therapeutically beneficial in alleviating airway inflammation and the control of asthma symptoms, but the evidence remains scanty and is often based on poorly characterised preparations. Accordingly, well-designed large clinical studies using chemically well characterised NS preparation are required.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Medicinal benefits of Nigella sativa in bronchial asthma: A literature review

Koshak

2017

Saudi Pharmaceutical Journal

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“…In addition, immune pathways driven by T-helper 2 (Th 2 ) cells which produce IL-4, IL-5, and IL-13 are contributing in the pathophysiology of this disease. The imbalance of Th 1 /Th 2 imbalance toward increased Th 2 activity was indicated in the pathogenesis of asthma and allergies [3, 4]. Cytokines released from Th 2 cells like IL- 4 and IL- 5 also stimulate IgE production by B cells which plays a role in allergic asthma [5].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum leaves and its effect on lung pathological changes in an ovalbumin-induced rat model of asthma

Eftekhar

Moghimi

Roshan

et al. 2019

BMC Complement Altern Med

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Background: Ocimum species (Lamiaceae) has been traditionally used for treatment of upper respiratory tract infections, bronchitis, coughs, sore throat, and wound healing. The Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum (O. basilicum) leaves was examined in ovalbumin sensitized animals. Methods: Wistar rats were divided to six groups; non-sensitized, sensitized to ovalbumin, sensitized and treated with dexamethasone (1.25 μg/mL), and O. basilicum extract (0.75, 1.50 and 3.00 mg/mL) in drinking water for 21 days. The levels of interleukin 4 (IL-4), interferon gamma (IFN-γ), IFN-γ/IL-4 ratio, immunoglobulin E (IgE), phospholipase A 2 (PLA 2) and total protein (TP) in BALF, and lung pathological changes were examined. Results: A significant increase in IL-4, IgE, PLA 2 and TP levels, all lung pathological indices as well as significant decrease in IFN-γ/IL-4 ratio was seen in the asthmatic compared to the control rats (P < 0.05 to P < 0.001). Treatment with O. basilicum extract resulted in decreased IL-4, IgE, PLA 2 and TP levels, but increased IFN-γ/IL-4 ratio compared to untreated sensitized rats (P < 0.01 to P < 0.001). The plant significantly improved the pathological changes of sensitized rats (P < 0.05 to P < 0.01). The improvement effects of higher concentrations of the O. basilicum extract were significantly more than those of dexamethasone (P < 0.05 to P < 0.001). Conclusion: The improvement effects of O. basilicum on pathological changes, immunological and inflammatory markers in sensitized rats comparable or even more potent than dexamethasone suggests the therapeutic potential of the plant in asthma.

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“…In the present study, a-hederin increased levels of miRNA-133a mRNA expression, which indicates the possible therapeutic effect of a-hederin on sensitized rats. In previous studies, the preventive effect of a-hederin on tracheal responsiveness, blood cytokines and lung inflammation of sensitized guinea pigs was demonstrated Saadat et al, 2015]. Moreover, a-hederin reduced the levels of miRNA-126, IL-13 mRNA and lung pathological changes in comparison with OVA-sensitized rats [Fallahi et al, 2016].…”

Section: Discussionmentioning

confidence: 95%

Effect of α‐Hederin on IL‐2 and IL‐17 mRNA and miRNA‐133a Levels in Lungs of Ovalbumin‐Sensitized Male Rats

Ebrahimi

Fallahi

Khamaneh

et al. 2016

Drug Development Research

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α-hederin, a saponin that is a major constituent of English Ivy (Hedera helix) is effective in the treatment of asthma. In the present study, the effect of α-hederin on lung tissue pathology and the levels of the inflammatory mediators; IL-2 mRNA, IL-17 mRNA, and MicroRNAs (miRNA)-133a was evaluated in a rat ovalbumin (OVA)-sensitized model of asthma. Rats were divided randomly into control (C), OVA-sensitized (S), OVA-sensitized pretreated with the antioxidant, thymoquinone (3 mg/kg, S + TQ) or OVA-sensitized pretreated with α-hederin (0.02 mg/kg, S + AH) groups. Levels of IL-2 and IL-17 mRNA were higher in the OVA-sensitized group than controls while the level of miRNA-133a gene expression was lower. IL-2 mRNA and miRNA-133a gene expression in the S + TQ group was higher than in the control and OVA-sensitized groups while the level of IL-17 mRNA in the S + TQ group was lower than in the OVA-sensitized group. Pretreatment with α-hederin decreased IL-17 mRNA levels and increased miRNA-133a gene expression compared with OVA-sensitized animals. All pathological changes in pretreated groups were lower than the OVA-sensitized group. These results showed a beneficial effect of α-hederin in OVA-sensitized rats, suggesting that α-hederin affects the IL-2 and IL-17 secretion pathways, altering miRNA-133a expression.

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The protective effect of α-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs

Cited by 25 publications

References 23 publications

Medicinal benefits of Nigella sativa in bronchial asthma: A literature review

Medicinal benefits of Nigella sativa in bronchial asthma: A literature review

Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum leaves and its effect on lung pathological changes in an ovalbumin-induced rat model of asthma

Effect of α‐Hederin on IL‐2 and IL‐17 mRNA and miRNA‐133a Levels in Lungs of Ovalbumin‐Sensitized Male Rats

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