The protective effect of vitamin E against genotoxicity of lead acetate intraperitoneal administration in male rat

Hamadouche, Nadia Ait; Sadi, Nesrine; Kharoubi, Omar; Slimani, Miloud; Aoues, Abderlkader

doi:10.2298/abs1304435h

Cited by 21 publications

(17 citation statements)

References 44 publications

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“…Rubio et al (2006) have stated that severe effects of lead on function of male genital system occur through changes in spermatogenesis and sperm function [37]. Various Overall, results of the lead effects on sperms in the current study are similar to those from other recent investigations [5,7,9,38]. Significant decreases in Sertoli and Leydig cells, height of germinal epithelium and diameter of seminiferous tubules in rats have been reported [5,9,38].…”

Section: Discussionsupporting

confidence: 88%

“…Negative effects of environmental chemical factors (e.g. lead) on male genital system have been considered intensively [7,31]. Exposing to lead threatens human and animal health [32].…”

Section: Discussionmentioning

confidence: 99%

“…Weight of genital organs, especially testes, decreases in oxidative stress; therefore, weighing testes is one of the most important parameters in toxicological studies. In similar studies, it has been reported that oxidative stress induced by lead causes decreased body weight, and net and relative weight and volume of testes in rats [7,9,30,38]. However, Asadpour et al (2013) reported that lead included no effects on body and testis weight in rats [5].…”

Section: Discussionmentioning

confidence: 99%

“…Control group received 1 ml/kg of normal saline as daily intraperitoneal injection. Lead group received 20 mg/kg of lead acetate as daily intraperitoneal injection [7,24,25]. WSE group received 100 mg/kg of wheat sprout extract orally (via gavage) daily.…”

Section: Methodsmentioning

confidence: 99%

“…Other resources of lead include storage of drinking water in tanks, packing food stuffs in newspapers and canned foods [4]. Effects of lead on male genital system and sperm fertility parameters have been shown [5][6][7]. Kakkar et al (2005) have shown that disorders in structure and function of male genital system and quality of sperms are principal symptoms of exposure to lead [8].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Adibmoradi¹,

Malekinejad²

2015

Reprod Syst Sex Disord

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Objective: Negative effects of lead on the male reproductive system and sperm fertility parameters have been shown broadly. In recent years, use of medicinal herbs in reducing heavy metal toxicities has increased worldwide. One of these herbals, wheat sprout, contains high amount of vitamins (especially vitamin E), antioxidants and phytoestrogen compounds. This study investigated the effects of wheat sprout extract (WSE) and vitamin E on testicular oxidative stress in rats exposed to lead acetate.Methods: Thirty-five rats were divided randomly into seven groups: G1 (control group) received 1 ml/kg/day of normal saline, G2 received 20 mg/kg/day of lead acetate, G3 and G4 received 100 mg/kg/day and 200 mg/kg/day of WSE respectively, G5 and G6 received 100 mg/kg/day and 200 mg/kg/day of WSE respectively with 20 mg/kg/day of lead acetate, and G7 received 100 mg/kg/day of vitamin E with 20 mg/kg/day of lead acetate. After 35 days, rats were sacrificed and blood, sperm, liver and testicle tissue samples were collected for histomorphological and histochemical studies.Results: Results showed that count, motility and viability of sperms decreased following the administration of lead acetate (P<0.01). Histomorphological studies showed a significant decrease in tubular differentiation index (TDI), spermiogenesis index (SI), repopulation index (RI), number of Leydig and Sertoli cells, and epithelium height and diameter of seminiferous tubules in groups receiving lead acetate (P<0.05). Conclusion:Summary, results of the current study show that dose dependent WSE significantly prevents testicular toxicity and oxidative stress effects of lead acetate.

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Section: Discussionsupporting

confidence: 88%

“…Negative effects of environmental chemical factors (e.g. lead) on male genital system have been considered intensively [7,31]. Exposing to lead threatens human and animal health [32].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Adibmoradi¹,

Malekinejad²

2015

Reprod Syst Sex Disord

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Naringenin alleviate reproductive toxicity evoked by lead acetate via attenuation of sperm profile and biochemical alterations in male Wistar rat: Involvement of TGFβ/AKT/mTOR pathway

Elhemiely

Yahia

Gad

2023

J Biochem & Molecular Tox

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Exposure to Lead -causes testicular dysfunction through oxidative stress, inflammation, and apoptosis; however, naringenin (NGN) therapeutic impact against lead-evoked testicular dysfunction remains elusive. Herein, the point of the study was to examine the defensive impact of NGN on testicular dysfunction initiated by lead. Seventy-Two male Wistar rats were allotted into nine groups; control group, drug control groups, lead acetate group, as well as NGN treated groups (10, 25, and 50 mg/kg) respectively, given 5 days before lead acetate treatment. The result showed clearly the impact of lead on reduced sperm count, sperm motility as well as serum testosterone and LH levels.Additionally, it caused a significant rise in testicular inflammatory markers TNF-α, IL-1β, and TGFβ, effects that were accompanied by a reduction of AKT and mTOR levels. Lead acetate also caused degenerative changes in the testis, atrophy, and loss of spermatogenic series. Our findings revealed that NGN in a dose-dependent manner improved spermiotoxicity induced by lead acetate via restoration of the testicular function, preservation of spermatogenesis, halting inflammatory cytokines along with the enhancement of germ cell survival using upregulation of AKT/mTOR expressions. The present study discloses that NGN suppresses lead acetate toxicity that is involved in the antioxidant effect in a dose-dependent manner, besides its anti-inflammatory property.

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Effect of LA on the Growth and Development of the Main Organs in Female Mice

Feng

et al. 2016

Biol Trace Elem Res

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Effects of lead acetate (LA) on the growth and development of major organs in female mice were studied. Female mice were divided randomly into four treatment groups and one control group. In treatment groups, mice were injected with different concentrations of LA solution every 2 days; whereas control-group mice received equal volumes of sterile normal saline. Body weight (BW) and symptoms were recorded every 2 days. After LA exposure, mice were executed by cervical dislocation and main organs (heart, liver, spleen, lung, kidney) collected for evaluation of morphologic and histologic changes. LA could greatly affect increases in BW, and BW decreased with increasing dose and time of exposure to LA. Compared with the control group, organ coefficients in treatment groups were of the order kidney and spleen > liver and lung > heart and demonstrated obvious dose-time effects. LA exposure could damage the heart, liver, spleen, lung, and kidney. Damage to the kidney and spleen was the most severe, followed by that to the liver, heart, and lung. Damage was aggravated with increasing doses and exposure time to LA in an obvious dose-time relationship; when LA dose was ≥20 mg/kg, the growth and development of mice were obviously inhibited. These results suggest that long-term exposure to low-dose LA can result in universal pathologic damage to mouse organs and that severity is dependent on the dose and duration of LA exposure.

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The protective effect of vitamin E against genotoxicity of lead acetate intraperitoneal administration in male rat

Cited by 21 publications

References 44 publications

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Naringenin alleviate reproductive toxicity evoked by lead acetate via attenuation of sperm profile and biochemical alterations in male Wistar rat: Involvement of TGFβ/AKT/mTOR pathway

Effect of LA on the Growth and Development of the Main Organs in Female Mice

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