Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Adibmoradi, M.; Malekinejad, Hassan

doi:10.4172/2161-038x.1000156

Cited by 13 publications

(15 citation statements)

References 35 publications

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“…A significant increase in Malondiadehyde level was observed in female cavies exposed to lead acetate in the present study. These results are in line with the observations of Adibmoradi et al (2015) after lead acetate administration. The significant increase in MDA level suggests that oxidative stress is a major mechanism of the effect of lead in organism.…”

Section: Discussionsupporting

confidence: 92%

Oxidative Stress and Reproductive Damage Induced by Lead Acetate in Female Guinea Pig (Cavia porcellus): Curative Effects of Hydroethanolic Extract of Spirulina platensis

Sorelle¹,

Ferdinand²,

Pascal³

et al. 2019

American Journal of Animal and Veterinary Sciences

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This study was aimed at evaluating the curative effects of Hydroethanolic Extract Of Spirulina platensis (HESP) on the reproductive function of female Guinea pig exposed to oxidative stress. Sixty females, 3-4 months old, weighing 300-400 g were divided into six groups (10 animals/group). The neutral control received distilled water, the negative control was treated with lead acetate at a dose 12 mg/kg.b.w while the positive control was given 12 mg of lead acetate/kg b.w and 100 mg of vitamin C. Groups 4, 5 and 6 were treated with lead acetate at a dose of 12 mg/kg b.w for the first 30 days and then received from the 31 st day to the 90 th day HESP at doses of 50,100 and 200 mg/kg.b.w respectively once daily. Results revealed that lead caused prominent toxic effects on fertility, deterioration of sex organs as well as a disruption of serum levels of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) and progesterone. Lead acetate markedly increased tissues oxidative-stress marker (malondiadehyde), whereas it reduces the activities of antioxidant-enzymes, Superoxide Dismutase (SOD), total peroxidase and catalase. These changes were also accompanied by a significant (p<0.05) decrease of body weight gain. However treatment with HESP ameliorated lead acetate-induced anomalies by significantly (p<0.05) increasing the body weight gain, organ weights and feed intake. Also HESP let to a significant (p<0.05) improvement of fertility indices, a significant (p<0.05) increase in serum LH, FSH, progesterone hormones and an increase in antioxidant enzymes. Curative treatment brought about histological tissues protection and a significant (p<0.05) decrease of toxicity biomarkers (AST, ALT, creatinine and urea) and Malondiadehyde (MDA). In conclusion, lead acetate induced reproductive stress and administration of HESP can mitigate these adverse effects due to its antioxidant properties.

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Section: Discussionsupporting

confidence: 92%

Oxidative Stress and Reproductive Damage Induced by Lead Acetate in Female Guinea Pig (Cavia porcellus): Curative Effects of Hydroethanolic Extract of Spirulina platensis

Sorelle¹,

Ferdinand²,

Pascal³

et al. 2019

American Journal of Animal and Veterinary Sciences

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“…Means of the spermiogenesis index (SI) and the tubal differential index (TDI) were considered for the evaluation of spermatogenesis. For the TDI index, the ratio of seminiferous tubules with four or more lines of differentiated cells of type A spermatogonia was calculated, while the ratio of seminal tubules containing spermatids was calculated for the SI index [26].…”

Section: Histomorphometric and Histochemicalmentioning

confidence: 99%

Signs of ROS-Associated Autophagy in Testis and Sperm in a Rat Model of Varicocele

Sadeghi

Erfani-Majd

Tavalaee

et al. 2020

Oxidative Medicine and Cellular Longevity

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Since autophagy was suspected to occur in the pathological situation of varicocele (VCL), we have attempted to confirm it here using a surgical model of varicocele-induced rats. Thirty Wistar rats were divided into three groups (varicocele/sham/control) and analyzed two months after the induction of varicocele. Testicular tissue sections and epididymal mature sperm were then monitored for classic features of varicocele, including disturbance of spermatogenesis, impaired testicular carbohydrate and lipid homeostasis, decreased sperm count, increased sperm nuclear immaturity and DNA damage, oxidative stress, and lipid peroxidation. At the same time, we evaluated the Atg7 protein content and LC3-II/LC3-1 protein ratio in testis and mature sperm cells, two typical markers of early and late cellular autophagy, respectively. We report here that testis and mature sperm show higher signs of autophagy in the varicocele group than in the control and sham groups, probably to try to mitigate the consequences of VCL on the testis and germ cells.

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“…It has been shown that antioxidants can prevent or reduce the oxidation of other molecules by ROS in a tissue or cell organisms, scavenge free radicals and attenuate their deleterious effects ( 11 12 ). Antioxidant activity or inhibition of generation of free radicals plays a crucial role in protection against such testicular toxicity.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats

Sudjarwo

Koerniasari³

2017

Res Pharma Sci

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In recent years, the use of the antioxidant in reducing heavy metal toxicities has increased worldwide. Curcumin has been reported to have a strong antioxidant activity. In this study, we investigated the protective effects of curcumin on lead acetate-induced testicular damage in rats. The sample used 40 male rats divided into 5 groups: negative control (rats were given daily with corn oil); positive control (rats were given daily with lead acetate 50 mg/kg BW orally once in a day for 35 days); and the treatment group (rats were given the curcumin 100 mg, 200 mg, and 400 mg/kg BW orally once in a day for 40 days, and on the 5th day, were given lead acetate 50 mg/kg BW one h after the curcumin administration). After 40 days, levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in testicular tissue, and sperm count, motility and viability in the epididymis were measured in rats. Testis samples were also collected for histopathological studies. Results showed that lead acetate administration significantly decreased the SOD, GPx, and increased MDA levels. Lead acetate also decreased the sperm count, motility, viability, and altered histopathological testis (testicular damage, necrosis of seminiferous tubules and loss of spermatid) compared to the negative control. However, administration of curcumin significantly improved the histopathological in testis, increased the sperm count, motility, viability, and also significantly increased the SOD, GPx, and decreased MDA in testis of lead acetate-treated rats. From the results of this study we concluded that the curcumin could be a potent natural product provide a promising protective effect against lead acetate induced testicular toxicity in rats.

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Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Cited by 13 publications

References 35 publications

Oxidative Stress and Reproductive Damage Induced by Lead Acetate in Female Guinea Pig (Cavia porcellus): Curative Effects of Hydroethanolic Extract of Spirulina platensis

Oxidative Stress and Reproductive Damage Induced by Lead Acetate in Female Guinea Pig (Cavia porcellus): Curative Effects of Hydroethanolic Extract of Spirulina platensis

Signs of ROS-Associated Autophagy in Testis and Sperm in a Rat Model of Varicocele

Protective effect of curcumin on lead acetate-induced testicular toxicity in Wistar rats

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