The protective effect of the alcoholic extract Lactuca serriola on some physiological parameters in the liver in white mice induced with Benzo(a)pyrene

Abstract

This study was conducted to investigate the possibility of using the alcoholic extract Lactuca serriole as a protective agent against the chemical compound benzopyrene that causes cancer. Alkanes are the dominant group in addition to the presence of phenol, alkene and ester, the highest concentration of the compound (1-Heneicosyl formate) (42.579) and the lowest concentration of the compound (1,6-Octadien3-ol, 3,7-dimethyl-, 2- aminobenzoate) by (1.009%), the results showed a significant decrease at the level of probability (P≥ 0.05) in the level of total protein in the liver in the group of animals that were dosed with carcinogenic benzopyrene in comparison with the healthy control group, while the effect on the level of total protein was less than in the group of animals that were dosed with carcinogenic benzopyrene, while the effect on the level of total protein was less than in the healthy control group In the groups that were dosed with alcoholic extract of wild lettuce plant with a concentration of 0.006mg/kg for the first group, 0.003 mg/kg for the second group, and a concentration of 0.0015mg/kg for the third group in conjunction with the benzene and pyrene carcinogen in comparison with the control group. It also showed a significant increase at the level of probability (0.05≥P) in the activity of the transaminase enzymes AST and ALT in the liver in the group of animals that were dosed with the carcinogenic substance benzopyrene compared to the healthy control group, while the effect on the level of enzymes was less in the groups that were dosed with alcoholic extract of wild lettuce plant with a concentration of 0.006mg/kg for the first group and 0.003mg/kg for the second group and 0.0015mg/kg for the third group in conjunction with the carcinogenic benzopyrene and compared with the control group.