The protective effect of protocatechuic acid on hepatotoxicity induced by cisplatin in mice

Habib, Sally A.; Suddеk, Ghada M.; Rahim, Mona Abdel; Abdelrahman, Rehab S.

doi:10.1016/j.lfs.2021.119485

Cited by 37 publications

(23 citation statements)

References 55 publications

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“…It was also reported that rutin could upregulate NRF2-mediated endogenous antioxidant responses by oxidizing to quinone to protect HUVECs from oxidative stress induced by H 2 O 2 [ 41 ]. Protocatechuic acid as one of the primary metabolites of cyanidin3-glucoside and cyanidin-3-rutinoside, also showed protective effects on hepatotoxicity induced by cisplatin in mice, through reducing MDA and NO levels and increasing GSH and SOD levels [ 42 ], could also reduce palmitic acid-induced oxidative damage to human umbilical vein endothelial cells (HUVECs) or high-fat diet-induced aortic oxidative damage in mice [ 43 , 44 ]. Therefore, a better biological activity of ZHP might be partially attributed to these compounds.…”

Section: Resultsmentioning

confidence: 99%

Phenolics Profile and Protective Effect on Injuried HUVEC Cells of Epicarp Extracts from Kadsura coccinea

Yang

Cheng

et al. 2022

Foods

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This study evaluated the phenolics profile and the antioxidative properties of K. coccinea fruits epicarp. A total of 13 phenolic compounds (six phenolic acids, four anthocyanins, two flavonols, and one flavone) were identified by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spetrometry(UPLC-QTOF-MS/MS). Two anthocyanins, cyanidin-3-xylosylrutinoside and cyanidin-3-rutinoside, comprise 30.89~74.76% and 13.90~46.17% of the total amount of anthocyanins in K. Coccinea. Cytoprotective effect results evidenced that pretreatment of Human umbilical vein endothelial cells(HUVECs) with Kadsura. coccinea fruits’ epicarp phenolic extracts at the concentrations of 50–200 µg/mL improved the cell viability after exposure to H2O2 significantly, and inhibited malonaldehyde(MDA) and reactive oxygen species(ROS) overproduction, as well as enhancing the content of superoxide dismutase (SOD) and glutathione Reductase (GR. This study proved that K. coccinea is a natural resource of phenolics rich with potential antioxidant ability, which may be valuable for developing nutraceuticals and dietary supplements.

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Section: Resultsmentioning

confidence: 99%

Phenolics Profile and Protective Effect on Injuried HUVEC Cells of Epicarp Extracts from Kadsura coccinea

Yang

Cheng

et al. 2022

Foods

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“…Bhattacharjee et al (Bhattacharjee et al 2017) showed that PCA inhibited ROS production, lipoperoxidation, and protein carbonylation, and increased GSH along with antioxidant enzymes (SOD, CAT, GR, GPx) in the myocardial tissue of diabetic rats. PCA was also found to protect hepatic tissue against oxidative damage by decreasing MDA level and enhancing level of GSH and SOD in response to cisplatin exposure (Habib et al 2021). Moreover, Al Olayan et al (Al Olayan et al 2020) stated that PCA provided neuroprotection against cadmium intoxication through enhancing cellular antioxidants gene expression and decreasing lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, PCA extracted from leaves of Trianthema portulcastrum was found to attenuate dermal wounds via inhibiting oxidative and in ammatory responses (Yadav et al 2017). Furthermore, PCA showed hepatoprotective activity following cisplatin exposure through enhancing antioxidant molecules and downregulating proin ammatory cytokines (Habib et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Protocatechuic acid counteracts oxidative stress and inflammation in carrageenan-induced paw edema in mice

Albarakati

2022

Environ Sci Pollut Res

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PCA (protocatechuic acid), a phenolic compound found in teas, fruits and vegetables, is widely recognized with its antioxidant and anti-in ammatory activities. Here we veri ed the protective role of PCA on carrageenan-induced paw edema in mice. PCA (25 mg/kg and 50 mg/kg) administration was applied for ve consecutive days prior to the carrageenan injection. Diclofenac sodium (20 mg/kg) was used as a reference drug. PCA pretreatment notably decreased the volume of the developed edema and alleviated the histopathological alterations induced by carrageenan. Additionally, PCA administration enhanced the cellular antioxidant capacity as demonstrated by the increased levels of catalase, superoxide dismutase and reduced glutathione, in addition to the decreased malondialdehyde level in the edematous tissue. Interestingly, PCA administration was able to suppress the developed in ammatory response upon carrageenan injection as indicated by the decreased levels and expression of proin ammatory cytokines and mediators including tumor necrosis factor alpha, interlukin-1 beta, interlukin-6, inducible nitric oxide synthase, nitric oxide, cyclooxygenase-II, prostaglandin E2, monocyte chemoattractant protein-1, myeloperoxidase and nuclear factor kappa B. These results collectively con rm the protective effect of PCA against carrageenan-induced paw edema owing to its antioxidant and anti-in ammatory characteristics.

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“…Part of the anthocyanins metabolism by the gut microbiota includes de-glycosylation (conversion of cyanidin-3-O-rutinoside into cyanidin-3-O-β-glucoside, and cyanidin aglycone), and the anthocyanin products degrade to small molecules, e.g., protocatechuic acid, gallic acid, syringic acid, and 3-Omethylgallic acid (Figure 5), which supposedly contribute to reported health benefits, and biological activities of the anthocyanin molecules [192][193][194][195]. Protocatechuic acid, the main metabolite of anthocyanins [196,197], exhibits antioxidant and anti-inflammatory activities, and has been demonstrated to provide liver-protecting effects in different models of liver injury [198][199][200][201].…”

Section: Anthocyanins' Metabolism In Livermentioning

confidence: 99%

Anthocyanins: Traditional Uses, Structural and Functional Variations, Approaches to Increase Yields and Products’ Quality, Hepatoprotection, Liver Longevity, and Commercial Products

Mohammed

Khan

2022

IJMS

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Anthocyanins are water-soluble, colored compounds of the flavonoid class, abundantly found in the fruits, leaves, roots, and other parts of the plants. The fruit berries are prime sources and exhibit different colors. The anthocyanins utility as traditional medicament for liver protection and cure, and importance as strongest plants-based anti-oxidants have conferred these plants products different biological activities. These activities include anti-inflammation, liver protective, analgesic, and anti-cancers, which have provided the anthocyanins an immense commercial value, and has impelled their chemistry, biological activity, isolation, and quality investigations as prime focus. Methods in extraction and production of anthocyanin-based products have assumed vital economic importance. Different extraction techniques in aquatic solvents mixtures, eutectic solvents, and other chemically reactive extractions including low acid concentrations-based extractions have been developed. The prophylactic and curative therapy roles of the anthocyanins, together with no reported toxicity has offered much-needed impetus and economic benefits to these classes of compounds which are commercially available. Information retrieval from various search engines, including the PubMed®, ScienceDirect®, Scopus®, and Google Scholar®, were used in the review preparation. This imparted an outlook on the anthocyanins occurrence, roles in plants, isolation-extraction, structures, biosynthetic as well as semi- and total-synthetic pathways, product quality and yields enhancements, including uses as part of traditional medicines, and uses in liver disorders, prophylactic and therapeutic applications in liver protection and longevity, liver cancer and hepatocellular carcinoma. The review also highlights the integrated approach to yields maximizations to meet the regular demands of the anthocyanins products, also as part of the extract-rich preparations together with a listing of marketed products available for human consumption as nutraceuticals/food supplements.

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The protective effect of protocatechuic acid on hepatotoxicity induced by cisplatin in mice

Cited by 37 publications

References 55 publications

Phenolics Profile and Protective Effect on Injuried HUVEC Cells of Epicarp Extracts from Kadsura coccinea

Phenolics Profile and Protective Effect on Injuried HUVEC Cells of Epicarp Extracts from Kadsura coccinea

Protocatechuic acid counteracts oxidative stress and inflammation in carrageenan-induced paw edema in mice

Anthocyanins: Traditional Uses, Structural and Functional Variations, Approaches to Increase Yields and Products’ Quality, Hepatoprotection, Liver Longevity, and Commercial Products

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