The protective effect of piperine on dextran sulfate sodium induced inflammatory bowel disease and its relation with pregnane X receptor activation

Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats

“…In addition to its function as spicy seasoning, pepper has also been valued as medicinal, preservative and perfumery ingredient and its pungent property is mainly attributed to PIP [2]. Recently, various beneficial effects of PIP have been revealed such as the anti-inflammation effect, immunomodulatory and anti-cancer activity, antispasmodic and anti-secretory effect [3][4][5][6]. Besides, PIP demonstrated significant neuroprotective effect for the treatment of Alzheimer's disease and Parkinson's disease [7,8].…”

Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium‐induced colitis in mice

“…IMP treatment for 7 days at a dosage of 100 mg·kg −1 notably increased Cyp3a11 and Mdr1 expression with little effect on the gene expression of mPXR (Figure A), indicating that IMP activates mPXR signalling in vivo . In line with the results of previous studies (Kusunoki et al ., ; Hu et al ., ; Zhang et al ., ), treatment of mice with DSS for 7 days notably down‐regulated the expression of colonic mPXR signalling and inhibited the increased expression of its target genes, Cyp3a11 and Mdr1 , in the colon (Figure B, C). However, treatment with IMP strongly attenuated the DSS‐induced decline in colonic mPXR expression (Figure B, C).…”

Thérapies complémentaires et alternatives : quelle place dans les maladies inflammatoires chroniques intestinales ?

“…En effet, il a été démontré que la rifaximine module le microbiote des patients atteints de maladie de Crohn en augmentant la concentration de Bifidobacteria et de Faecalibacterium prausnitzii. D'autress ubstances ont étéé tudiées mais uniquement sur modèle animal pour le maintien de l'intégrité de la barrière intestinale :l ap ipérine et la baicalein [13,14] ;…”