Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats

Li, Chenrui; Wang, Qin; Ren, Tianjing; Zhang, Yufeng; Lam, Christopher Wai Kei; Chow, Moses S. S.; Zuo, Zhong

doi:10.1016/j.jpba.2016.05.041

Cited by 32 publications

(18 citation statements)

References 25 publications

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“…Piperine has long been used as a traditional medicine, preservative, and insecticide in addition to the more commonly known seasoning and perfuming applications. Piperine has also been proven to be effective in improving the pharmacokinetics of poorly bioavailable drugs and other medicinal herbs through inhibiting P-gp and CYP450 metabolism in intestinal epithelial cells [2,[5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models

et al. 2019

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The fruit from various pepper plants has been employed for the seasoning of food, as perfuming agents, and also as traditional medicines. Phytochemicals isolated from different pepper species have been found to modulate the pharmacokinetics of orally administered drugs. This study investigated the possibility to apply capsaicin and piperine (extracted alkaloids) as modulators for drug delivery across the nasal epithelium. Both a nasal epithelial cell line (RPMI 2650) and excised sheep nasal tissue were used as models to investigate the effects of the selected pepper compounds on drug permeation. FITC-dextran 4400 (MW 4400 Da) was used as a large molecular weight marker compound for paracellular transport, while rhodamine 123 was used as a marker compound that is a substrate for P-glycoprotein-mediated efflux. From the permeation results, it was clear that capsaicin inhibited P-glycoprotein efflux to a larger extent, while piperine showed drug permeation enhancement via other mechanisms. The cell cytotoxicity studies indicated that capsaicin was noncytotoxic up to a concentration of 200 µM and piperine up to a concentration of 500 µM as indicated by cell viability above 80%. The histological analysis of the excised nasal tissue and cultured RPMI 2650 cell layers indicated that some damage occurred after treatment with 200 µM capsaicin, but no changes were observed for piperine up to a concentration of 50 µM.

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Section: Introductionmentioning

confidence: 99%

Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models

et al. 2019

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“…is reported to alter the pharmacokinetics of docetaxel (7 mg/kg i.v.) in rats, resulting in an increase in the C max (from 1,625.52 ± 355.53 to 6,603.58 ± 1889.89 ng/ml) and AUC (from 48,091.93 ± 5,392.78 to 77,780.29 ± 11,963.62 min ng/ml) ( p < .001) (Li et al, ). In a crossover study performed by Bano et al, six healthy human volunteers were treated with piperine (20 mg) daily for 7 days followed by a single dose of propranolol (40 mg) and theophylline (150 mg) on two different occasions.…”

Section: Herbs Administered In Cvd and Their Reported Hdi With Cardiomentioning

confidence: 99%

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Shaikh

Thomas

Chitlange

2020

Phytotherapy Research

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About 70% of the world population is currently using medicinal herbs as complementary or alternative medicine, which is increasing at a tremendous pace in both developed and developing countries in the last two decades (World Health Organization Medicines Strategy 2002–2005). This increase in consumer demand of medicinal herbs continues despite the rarity of scientific data to establish their safety and efficacy profile. Its popularity is also attributed to several factors, including easy availability, cost effectiveness leading to better purchasing power and general perception that they are safe. Herbs are often administered concomitantly with therapeutic drugs for the treatment of major ailments, raising the potential for herb–drug interactions (HDIs). The major pathways postulated for HDIs involves the cytochrome P450 (CYP450)‐mediated inhibition or induction and transport and efflux proteins. In our review, we highlight frequently used herbal medicines for the treatment of cardiovascular disorders (CVD), their established HDIs studied using in vitro tools and in vivo pharmacokinetic and pharmacodynamic assays and case reports. Herbs have been divided into different sections on the basis of availability of HDI data in relevance to cardiovascular drugs: herbs reported to interact with cardiac drugs, herbs yet to be reported for interaction with drugs of any class and herbs reported to interact with drugs of other therapeutic category but not with cardiac drugs. The amount of active phytoconstituents present in the selected herbs and their extent of bioavailability are also mentioned. This review can serve as a quick reference database for physicians and health care professionals involved in CVD treatment, aimed at maximizing clinical outcomes with reduction in adverse and toxic effects.

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“…Piperine (1-piperoylpiperidine) is a major bioactive alkaloid constituent of long pepper ( Piper longum L.) and black pepper ( Piper nigrum L.) [ 28 , 29 , 30 ]. Piperine is believed to have anti-inflammatory, anti-hypertensive and hepatic protective properties [ 29 , 30 ]. It is often combined with other herbal medicines such as curcumin and was found to enhance the absorption of these co-administered herbs and drugs [ 31 ].…”

Section: Potential Beneficial Pharmacokinetic Interactions Betweenmentioning

confidence: 99%

Beneficial Pharmacokinetic Drug Interactions: A Tool to Improve the Bioavailability of Poorly Permeable Drugs

et al. 2018

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Simultaneous oral intake of herbs, supplements, foods and drugs with other drug(s) may result in pharmacokinetic or pharmacodynamic interactions with the latter. Although these interactions are often associated with unwanted effects such as adverse events or inefficacy, they can also produce effects that are potentially beneficial to the patient. Beneficial pharmacokinetic interactions include the improvement of the bioavailability of a drug (i.e., by enhancing absorption and/or inhibiting metabolism) or prolongation of a drug’s plasma level within its therapeutic window (i.e., by decreasing excretion), whereas beneficial pharmacodynamic interactions include additive or synergistic effects. Mechanisms by which pharmacokinetic interactions can cause beneficial effects include enhancement of membrane permeation (e.g., structural changes in the epithelial cell membranes or opening of tight junctions), modulation of carrier proteins (e.g., inhibition of efflux transporters and stimulation of uptake transporters) and inhibition of metabolic enzymes. In the current review, selected pharmacokinetic interactions between drugs and various compounds from different sources including food, herb, dietary supplements and selected drugs are discussed. These interactions may be exploited in the future to the benefit of the patient, for example, by delivering drugs that are poorly bioavailable in therapeutic levels via alternative routes of administration than parenteral injection.

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Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats

Cited by 32 publications

References 25 publications

Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models

Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models

Herb–drug interaction studies of herbs used in treatment of cardiovascular disorders—A narrative review of preclinical and clinical studies

Beneficial Pharmacokinetic Drug Interactions: A Tool to Improve the Bioavailability of Poorly Permeable Drugs

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