The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation

Peng, Xiang-Ping; Li, Xiaohong; Yang, Li; Huang, Xiaoting; Luo, Ziqiang

doi:10.1016/j.intimp.2019.03.018

Cited by 47 publications

(23 citation statements)

References 46 publications

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“…Both pathways can initiate caspase family proteins, including Caspase-3, Caspase-7, Caspase-8, etc. These proteins activate deoxyribonuclease, leading to chromosomal DNA fragmentation during apoptosis [19,20].…”

Section: Discussionmentioning

confidence: 99%

Nanocrystallized Oleanolic Acid Better Inhibits Proliferation, Migration and Invasion in Intracranial Glioma via Caspase-3 Pathway

et al. 2020

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Glioma associates with high malignancy and poor prognosis for traditional treatment. Oleanolic acid (OA) has been confirmed to have an inhibitory effect on different kinds of tumors, while accompanying with low efficiency because of its large molecular mass and low solubility. Nanoliposome is an appropriate drug delivery system that can compensate for the limitations of traditional insoluble drugs, involving improvement of their solubility, stability and lipophilicity. In the present study, we comprised of OA covered with nanoliposomes, named OA nano , to observe antitumor effects on U87 glioma cells. The results showed that OA nano raised the solubility and oil-water partition coefficient. OA nano suppressed proliferation of U87 glioma cells, and also had an anticancer effect on U87 glioma cells, which was found to be higher than that of OA. Moreover, treatment with OA nano induced apoptosis and degraded migration ability by caspase-3 pathway. In conclusion, our results demonstrated that OA covered with nanoliposomes led to enhanced anticancer effects by suppressing proliferation, migration and invasion abilities. The findings may provide a reliable reference for development of new anti-cancer drugs.

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Section: Discussionmentioning

confidence: 99%

Nanocrystallized Oleanolic Acid Better Inhibits Proliferation, Migration and Invasion in Intracranial Glioma via Caspase-3 Pathway

et al. 2020

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“…Oleanolic acid (OA) 83 is a pentacyclic triterpenoid compound found in Prunella vulgaris L. Previous study demonstrated that OA could effectively alleviate lung injury and play a protective role in N -methyl- d -aspartate (NMDA)-induced ALI murine model and NMDA-stimulated MLE-12 cells, which were associated with its anti-inflammatory, anti-oxidant and anti-apoptosis effects. Both SIRT1 and NF-κB were involved in the process [ 264 ]. Moreover, another study demonstrated that OA could also alleviate lung injury induced by paraquat via its anti-inflammatory and anti-oxidant activities [ 265 ].…”

Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

230

121

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“…SIRT1 has also been proven to modify Sox9 by deacetylation, which can promote the chondrogenic differentiation of stem cells [24,25]. In addition, SIRT1 can affect deacetylation and nuclear translocation of nuclear factor-kappa B (NF-κB) subunit Rel/p65, thereby reducing the apoptosis rate and improving antioxidant activity of cells in inflammation and aging [26,27]. However, the role of SIRT1 in chondrogenic differentiation and cartilage maintenance in MSCs is poorly understood.…”

Section: Agingmentioning

confidence: 99%

The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress

Lü

Zhou

Wang

et al. 2020

Aging

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Articular cartilage defects are common in the clinic but difficult to treat. Exploring the chondrogenic molecular mechanisms of mesenchymal stem cells (MSCs) is of great theoretical interest and industrial significance. Bone morphogenetic protein 2 (BMP2) is a key factor that induces cartilage differentiation and can induce stem cell chondrogenic differentiation. However, the oxidative stress in the microenvironment during cartilage injury and degeneration inhibits cartilage regeneration and homeostasis. Silent mating type information regulator 2 homolog-1 (SIRT1) is an important histone deacetylase that regulates proliferation, differentiation, aging, and inflammation processes; moreover, it is an essential factor for chondrogenesis. The specific mechanism of SIRT1 in cartilage differentiation and homeostasis is still unclear. First, we investigated whether SIRT1 could coordinate BMP2-induced chondrogenic differentiation. Second, we investigated the protective effect of SIRT1 on BMP2-induced MSCs under oxidative stress. The results showed that SIRT1 could promote BMP2-induced chondrogenic differentiation of MSCs, and reduce the apoptosis and decomposition of extracellular matrix under oxidative stress. In summary, these results suggested that SIRT1 plays an important coordination role in BMP2-induced chondrogenic differentiation of stem cells and cartilage maintenance under oxidative stress, establishing the experimental basis for exploring the use of SIRT1 in cartilage defect repair.

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The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation

Cited by 47 publications

References 46 publications

Nanocrystallized Oleanolic Acid Better Inhibits Proliferation, Migration and Invasion in Intracranial Glioma via Caspase-3 Pathway

Nanocrystallized Oleanolic Acid Better Inhibits Proliferation, Migration and Invasion in Intracranial Glioma via Caspase-3 Pathway

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress

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