The Protective Effect of New Compound XH‐103 on Radiation‐Induced GI Syndrome

Dong, Yinping; Cheng, Ying; Hou, Qinlian; Wu, Jing; Li, Deguan; Tian, Hongqi

doi:10.1155/2018/3920147

Cited by 10 publications

(5 citation statements)

References 38 publications

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“…In this study, we found that the expression level of γH2AX was lower in the TZC01 group than in the solvent group. Caspase-3 is an apoptotic executor, which was used as an indicator of intestinal cell apoptosis in our study [ 31 , 32 ]. Caspase-3 gene expression in γ-radiation-induced cardiac apoptosis was significantly downregulated by zingerone in previous reports [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury

Duan

Cui

et al. 2019

Journal of Radiation Research

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Abstract Intestinal injury is the primary toxicity of radiotherapy for pelvic and abdominal tumors, and it is also one of the common acute complications of radiotherapy. At present, there are no effective drugs to prevent intestinal injury in the clinic. Zingerone is a natural product with radioprotective effects. In this study, a novel compound (thiazolidine hydrochloride, TZC01) was synthesized by structural modification of zingerone. The effects of TZC01 on preventing intestinal injury from radiation were further investigated in this study. C57BL/6N mice were exposed to a lethal dose of abdominal irradiation (ABI) with and without TZC01 treatments. The morphological changes of the intestine and various makers of intestinal crypt cells were investigated. Treatment with TZC01 improved the survival rate of mice exposed to 12 Gy ABI. Moreover, TZC01 protected the intestinal morphology of mice, decreased the apoptotic rate of intestinal crypt cells, maintained cell regeneration and promoted crypt cell proliferation and differentiation. This study suggests that TZC01 has preventive and therapeutic effects on radiation enteritis by promoting the proliferation and differentiation of crypt cells to protect the small intestine from the toxic effects of ionizing radiation. Furthermore, the study of TCZ01 lays a strong foundation for developing novel radioprotectors with multiple properties.

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Section: Discussionmentioning

confidence: 99%

Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury

Duan

Cui

et al. 2019

Journal of Radiation Research

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“…The maintenance of intestinal structural integrity is essential for intestinal absorption and defense function. After radiation, varying degrees of villi dullness and fusion, attenuation and hypertrophy of villi epithelial cells, and severe crypt loss may occur, leading to the destruction of epithelial homeostasis and epithelial integrity [ 9 ]. In addition to the ability of the intestinal epithelium to continuously renew itself, the intestine shows remarkable intestinal renewal and repair capacity after damage [ 29 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation

Zheng¹,

Shi²,

Nie³

et al. 2023

Heliyon

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“…Survival rate is a gold standard indicator of whether a drug is radioprotective 26,27 . The mortality and survival days are influenced by many factors such as radiation sources, dose, and age and weight of the mice.…”

Section: Discussionmentioning

confidence: 99%

The protective effects of Xuebijing injection on intestinal injuries of mice exposed to irradiation

Dong

Zhang

Wang

et al. 2022

Anim Models and Exp Med

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Background: Gastrointestinal (GI) injury is one of the most common side effects of radiotherapy. However, there is no ideal therapy method except for symptomatic treatment in the clinic. Xuebijing (XBJ) is a traditional Chinese medicine, used to treat sepsis by injection. In this study, the protective effects of XBJ on radiation-induced intestinal injury (RIII) and its mechanism were explored. Methods:The effect of XBJ on survival of irradiated C57BL/6 mice was monitored.Histological changes including the number of crypts and the length of villi were evaluated by H&E. The expression of Lgr5 + intestinal stem cells (ISCs), Ki67 + cells, villin and lysozymes were examined by immunohistochemistry. The expression of cytokines in the intestinal crypt was detected by RT-PCR. DNA damage and apoptosis rates in the small intestine were also evaluated by immunofluorescence. Results:In the present study, XBJ improved the survival rate of the mice after 8.0 and 9.0 Gy total body irradiation (TBI). XBJ attenuated structural damage of the small intestine, maintained regenerative ability and promoted proliferation and differentiation of crypt cells, decreased apoptosis rate and reduced DNA damage in the intestine. Elevation of IL-6 and TNFα was limited, but IL-1, TNF-𝛽 and IL-10 levels were increased in XBJ-treated group after irradiation. The expression of Bax and p53 were decreased after XBJ treatment. Conclusions:Taken together, XBJ provides a protective effect on RIII by inhibiting inflammation and blocking p53-related apoptosis pathway.

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The Protective Effect of New Compound XH‐103 on Radiation‐Induced GI Syndrome

Cited by 10 publications

References 38 publications

Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury

Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury

Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation

The protective effects of Xuebijing injection on intestinal injuries of mice exposed to irradiation

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