The protective effect of nedocromil sodium and other drugs on airway narrowing provoked by hyperosmolar stimuli: A role for the airway epithelium?☆☆☆★★★

Anderson, Sandra D.; Rodwell, Leanne T.; Daviskas, Evangelia; Spring, J; Toit, Jacqueline du

doi:10.1016/s0091-6749(96)70028-3

Cited by 31 publications

(12 citation statements)

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“…Premature switching to oronasal breathing results in inadequate conditioning and fi ltering of the inspired air, with drying and cooling of the lower airways, subsequent release of infl ammatory cell mediators and development of an asthmatic response (41) and asthma chronicity. There are different PNIF meters in clinical use, and our study is based on In-check DIAL which has a scale from 15 to 120 L/ min.…”

Section: Discussionmentioning

confidence: 99%

The determining factors of peak nasal inspiratory flow and perception of nasal airflow in asthmatics

Thorstensen

Sue‐Chu

Bugten

et al. 2014

Rhin

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Background: The effect of pulmonary pathology on peak nasal inspiratory flow (PNIF) remains largely unknown. We investigated an association between a diagnosis of asthma and of lung function on PNIF when adjusted for possible confounders. Further, we investigated the perception of nasal obstruction in asthmatics compared to healthy controls when adjusted for PNIF.Methodology: Eighty-seven asthmatics and 92 non-asthmatic controls underwent PNIF (categorized into groups of high, medium and low), acoustic rhinometry (AR) and spirometry, and we assessed symptoms of nasal obstruction on visual analogue scales (VAS) in three categories.Results: PNIF was significantly associated with asthma and forced expiratory volume in the first second (FEV1) (% predicted).Other factors associated with PNIF were the degree of nasal obstruction measured both subjectively on a VAS and objectively with AR, age and disease status. Asthma patients were 19 times more likely to be in a higher VAS category compared to non-asthmatic controls independent of PNIF group. Conclusion:Special care has to be taken when interpreting PNIF values in patients with asthma or reduced FEV1 (% predicted).The sensation of nasal obstruction in asthmatics is different from controls despite being in the same PNIF group.

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Section: Discussionmentioning

confidence: 99%

The determining factors of peak nasal inspiratory flow and perception of nasal airflow in asthmatics

Thorstensen

Sue‐Chu

Bugten

et al. 2014

Rhin

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“…Hallstrand et al (61) demonstrated release of the mediators histamine, tryptase and cysteinyl leukotrienes into the sputum together with columnar epithelial cells whereas prostaglandin E(2) and thromboxane B(2) significantly decreased. It is thought that biochemical events associated with regulatory volume changes of the cells in response to an osmotic stimulus are associated with the biochemical events that are involved in the release of mediators (62). Under conditions of significant respiratory heat loss both mechanisms may work together to cause EIA.…”

Section: Pathogenesis Of Eiamentioning

confidence: 99%

Exercise‐induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: Part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA²LEN

Carlsen

Anderson

Bjermer³

et al. 2008

Allergy

289

269

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Aims: To analyze the changes in the prevalence of asthma, bronchial hyperresponsiveness (BHR) and allergies in elite athletes over the past years, to review the specific pathogenetic features of these conditions and to make recommendations for their diagnosis. Methods: The Task Force reviewed present literature by searching Medline up to November 2006 for relevant papers by the search words: asthma, bronchial responsiveness, EIB, athletes and sports. Sign criteria were used to assess level of evidence and grades of recommendation.Results: The problems of sports-related asthma and allergy are outlined. Epidemiological evidence for an increased prevalence of asthma and BHR among competitive athletes, especially in endurance sports, is provided. The mechanisms for development of asthma and bronchial hyperresponsiveness in athletes are outlined. Criteria are given for the diagnosis of asthma and exercise induced asthma in the athlete. Conclusions: The prevalence of asthma and bronchial hyperresponsiveness is markedly increased in athletes, especially within endurance sports. Environmental factors often contribute. Recommendations for the diagnosis of asthma in athletes are outlined.

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“…One previous paediatric investigation compared salbutamol to a combination of nedocromil and salbutamol and found that both regimens offered substantial protection [31]. More recently, nedocromil was shown to protect against the consequences of epithelial lining fluid hyperosmolarity, by interfering with regulatory cell volume changes [9]. As indicated by bronchoalveolar lavage findings, such cell volume changes lead to EIB via release of various mediators from different cell systems [10].…”

Section: Discussionmentioning

confidence: 99%

“…Hyperpnoea effects respiratory water loss, mucosal drying and cooling [6,7]. Recent work has suggested that the resulting hyperosmolarity of the epithelial lining fluid may lead to regulatory volume changes of airway epithelial cells [8,9]. This results in the release of various bronchoconstrictive mediators from cells in the bronchial mucosa [10].…”

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confidence: 99%

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Effects of nedocromil and salbutamol on airway reactivity in children with asthma

Pfleger¹,

Eber²,

Weinhandl³

et al. 2002

European Respiratory Journal

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The protective effect of nedocromil sodium and other drugs on airway narrowing provoked by hyperosmolar stimuli: A role for the airway epithelium?☆☆☆★★★

Cited by 31 publications

References 0 publications

The determining factors of peak nasal inspiratory flow and perception of nasal airflow in asthmatics

The determining factors of peak nasal inspiratory flow and perception of nasal airflow in asthmatics

Effects of nedocromil and salbutamol on airway reactivity in children with asthma

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