The protective effect of melatonin supplementation against taxol-induced testicular cytotoxicity in adult rats

Aboelwafa, Hanaa R.; Ramadan, R A; El‐kott, Attalla F.; Abdelhamid, F M

doi:10.1590/1414-431x2021e11614

Cited by 7 publications

(7 citation statements)

References 37 publications

(40 reference statements)

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“…The present results revealed a remarkable serum sex hormone levels improvement in MLT-treated irradiated rats, thereby restoring germ-cell and somatic cell population in the testis. These findings are compatible with a recent report that MLT directly affects the testis and testosterone synthesis from Leydig cells in animals [ 56 ]. Thus, MLT may promote male reproductive performance and increase testosterone synthesis in mammalian Leydig cells.…”

Section: Discussionsupporting

confidence: 94%

Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties

et al. 2022

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Background Ionizing radiations (IR) have widespread useful applications in our daily life; however, they have unfavorable effects on reproductive health. Maintaining testicular health following IR exposure is an important requirement for reproductive potential. The current study explored the role of melatonin (MLT) in mitigating IR-induced injury in young adult rat testis. Methods Rats were given daily MLT (25 mg/kg) for 3 and 14 days after receiving 4 Gy γ-radiation. Results Serum MLT levels and other antioxidants, including glutathione content, and the activity of glutathione peroxidase and glutathione reductase in the testis of the irradiated rats were remarkably maintained by MLT administration in irradiated rats. Hence, the hydrogen peroxide level declined with remarkably reduced formation of oxidative stress markers, 4-hydroxynonenal, and 8-Hydroxy-2′-deoxyguanosine in the testis of irradiated animals after MLT administration. The redox status improvement caused a remarkable regression of proapoptotic protein (p53, Cyto-c, and caspase-3) in the testis and improved inflammatory cytokines (CRP and IL-6), and anti-inflammatory cytokine (interleukin IL-10) in serum. This is associated with restoration of disturbed sex hormonal balance, androgen receptor upregulation, and testicular cell proliferation activity in irradiated rats, explaining the improvement of sperm parameters (count, motility, viability, and deformation). Consequently, spermatogenic cell depletion and decreased seminiferous tubule diameter and perimeter were attenuated by MLT treatment post irradiation. Moreover, the testis of irradiated-MLT-treated rats showed well-organized histological architecture and normal sperm morphology. Conclusions These results show that radiation-induced testicular injury is mitigated following IR exposure through synergistic interdependence between the antioxidant, anti-inflammatory, anti-apoptotic, and anti-DNA damage actions of MLT.

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Section: Discussionsupporting

confidence: 94%

Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties

et al. 2022

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“…But it has severe side effects in other organs, including the reproductive system (Honore et al, 2005;Wang et al, 2017). Many histological and ultrastructural changes, including thickening of the tunica albuginea and basal lamina, and degenerative changes in spermatogenic, Sertoli and Leydig cells were seen in the testis of rats treated with Taxol, but co-treatment of melatonin and taxol caused the modulation of histomorphometric and ultrastructural changes, and with increased expression of BCL-2 and decreased expression of P53 and Caspase 3, decreased the amount of apoptosis in testicular tissue (Aboelwafa et al, 2022).…”

Section: Taxolmentioning

confidence: 99%

Overview of biological effects of melatonin on testis: A review

et al. 2022

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Infertility is a major global health issue and male factors account for half of all infertility cases. One of the causes of male infertility is the loss of spermatogonial stem cells, which may occur because of chemotherapy, radiotherapy or genetic defects. In numerous animal species, the evidence suggests the pineal gland and melatonin secretion in their reproductive activities are involved. Recently, considerable attention has pointed to the usage of melatonin in the treatment of diseases. Melatonin is associated with the regulation of circadian and seasonal rhythmic functions, immune system functions, retinal physiology, spermatogenesis and inhibition of tumour growth in different species. Several studies demonstrated that melatonin acts as an anti‐apoptotic, anti‐inflammatory, anticancer and antioxidant agent. Melatonin can also protect testicles and spermatogonia against oxidative damage, chemotherapy drugs, environmental radiation, toxic substances, hyperthermia, ischemia/reperfusion, diabetes‐induced testicular damage, metal‐induced testicular toxicity, improve sperm quality and it affects the testosterone secretion pathway by affecting Leydig cells. Therefore, the objective of this study is to investigate the biological effects of melatonin as a natural antioxidant on testicles and their disorders.

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“…Quercetin co-treatment showed a significant reduction in the interstitial space in the arsenic-treated group [ 78 ]. Melatonin co-treatment showed a significant reduction in the thickness of tunica albuginea in the taxol-treated group [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

Hesperidin Mitigates Cyclophosphamide-Induced Testicular Dysfunction via Altering the Hypothalamic Pituitary Gonadal Axis and Testicular Steroidogenesis, Inflammation, and Apoptosis in Male Rats

et al. 2023

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Cyclophosphamide (CP) is a cytotoxic, cell cycle, non-specific, and antiproliferative drug. This study aimed to address the toxic effects of CP on male fertility and the possible ameliorative role of hesperidin (HSP). Thirty-two adult albino rats were randomly divided into four groups, namely, the negative control, HSP, CP-treated, and CP+HSP-treated groups. The CP-treated rats showed a significant reduction in the levels of serum LH, FSH, testosterone, prolactin, testicular glutathione peroxidase (GPx), and total antioxidant capacity (TAC) with an elevation in levels of malondialdehyde (MDA), and p53, and iNOS immune expression, compared to the control group. A significant downregulation in hypothalamic KISS-1, KISS-1r, and GnRH, hypophyseal GnRHr, and testicular mRNA expression of steroidogenesis enzymes, PGC-1α, PPAR-1, IL10, and GLP-1, as well as a significant upregulation in testicular mRNA of P53 and IL1β mRNA expression, were detected in the CP-treated group in comparison to that in the control group. The administration of HSP in CP-treated rats significantly improved the levels of serum LH, FSH, testosterone, prolactin, testicular GPx, and TAC, with a reduction in levels of MDA, and p53, and iNOS immune expression compared to the CP-treated group. A significant upregulation in hypophyseal GnRHr, and testicular mRNA expression of CYP19A1 enzymes, PPAR-1, IL10, and GLP-1, as well as a significant downregulation in testicular mRNA of P53 and IL1β mRNA expression, were detected in the CP+HSP-treated group in comparison to that in the CP-treated group. In conclusion, HSP could be a potential auxiliary agent for protection from the development of male infertility.

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The protective effect of melatonin supplementation against taxol-induced testicular cytotoxicity in adult rats

Cited by 7 publications

References 37 publications

Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties

Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties

Overview of biological effects of melatonin on testis: A review

Hesperidin Mitigates Cyclophosphamide-Induced Testicular Dysfunction via Altering the Hypothalamic Pituitary Gonadal Axis and Testicular Steroidogenesis, Inflammation, and Apoptosis in Male Rats

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