The protective effect of Lactobacillus and Bifidobacterium as the gut microbiota members against chronic urticaria

Rezazadeh, Akram; Shahabi, Shahram; Bagheri, Mohammad; Nabizadeh, Edris; Jazani, Nima Hosseini

doi:10.1016/j.intimp.2018.04.007

Cited by 32 publications

(44 citation statements)

References 48 publications

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“…At the phylum level, when compared with healthy controls, there was a relative reduced abundance of Bacteroidetes and Firmicutes in CSU patients, which is partly in agreement with the airway allergies in young children (Chiu et al, 2019). At the genus level, members of the Bacteroides, Faecalibacterium, Bifidobacterium, Lactobacillus, and unidentified Ruminococcaceae were relatively lower and members of unidentified Enterobacteriaceae were relatively increased compared to healthy controls, which is partly consistent with previous studies about CU or allergic diseases (Sjogren et al, 2009;Johansson et al, 2011;Candela et al, 2012;Nabizadeh et al, 2017;Rezazadeh et al, 2018;Chiu et al, 2019). For example, Nabizadeh et al (2017) and Rezazadeh et al (2018) reported a depletion in the relative amounts of Faecalibacterium prausnitzii, Clostridia, Akkermansia muciniphila, Bifidobacterium, and Lactobacillus in CU patients.…”

Section: Discussionsupporting

confidence: 88%

“…We previously conducted an epidemiologic investigation and found relevant evidence linking gut microbiota and CSU. Several studies have suggested that the changes in gut microbiota composition are linked to CU, including Akkermansia muciniphila, Faecalibacterium prausnitzii, the Clostridium leptum group, the Enterobacteriaceae family (Nabizadeh et al, 2017), and the Lactobacillus, Bifidobacterium, and Bacteroides genera (Rezazadeh et al, 2018); however, there is no specific mechanism by which to explore the dysbiosis of gut microbiota in the pathogenesis of CSU.…”

Section: Introductionmentioning

confidence: 99%

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Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Patients With Chronic Spontaneous Urticaria

Wang

Guo

et al. 2020

Front. Cell. Infect. Microbiol.

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Chronic urticaria (CU) is defined as the continuous or intermittent presence of urticaria for a period exceeding 6 weeks and sometimes occurring with angioedema. Between 66 and 93% of patients with CU have chronic spontaneous urticaria (CSU), the precise pathogenesis of which is largely unknown. The aim of this study was to determine the relationship between gut microbiota and serum metabolites and the possible pathogenesis underlying CSU. We collected feces and blood samples from CSU patients and healthy controls and the relationship between gut microbiota and serum metabolites was assessed using 16S rRNA gene sequencing and untargeted metabolomic analyses. The CSU group exhibited decreased alpha diversity of the microbial population compared to the control group. The abundance of unidentified Enterobacteriaceae was increased, while the abundance of Bacteroides, Faecalibacterium, Bifidobacterium, and unidentified Ruminococcaceae was significantly reduced in CSU patients. The serum metabolome analysis revealed altered levels of docosahexaenoic acid, arachidonic acid, glutamate, and succinic acid, suggesting changes in unsaturated fatty acids and the butanoate metabolism pathway. The combined serum metabolomics and gut microbiome datasets were correlated; specifically, docosahexaenoic acid, and arachidonic acid were positively correlated with Bacteroides. We speculate that alterations in gut microbes and metabolites may contribute to exacerbated inflammatory responses and dysregulated immune function with or without regulatory T cell dependence in the pathogenesis of CSU.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Patients With Chronic Spontaneous Urticaria

Wang

Guo

et al. 2020

Front. Cell. Infect. Microbiol.

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“…In addition, this review emphasis on further research to evaluate how probiotics and prebiotics could be better used in dermatology. In a study by Rezazadehet al, (35) from Iran, authors investigated the protective effect of Lactobacillus and Bifidobacterium against chronic urticaria. In this study, stool samples of 20 patients with chronic urticaria were compared with 20 age-and sex-matched healthy controls in terms of Lactobacillus, Bifidobacterium and Bacteroides contents.…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Probiotic as an adjuvant therapy in chronic urticaria: a blinded randomized controlled clinical trial

Atefi

Fallahpour

Sharifi

et al. 2022

Eur Ann Allergy Clin Immunol

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“…40 Overall, the presence of these two strands has been linked to better health in general, with a reduction of mood disorders 41 and other conditions. 42,43 Overall, it appears that microbiota modulation impacts inflammation in the organism. In Table 1, the effect of consumption of luteolin and other flavonoids on microbiota composition are described.…”

Section: Flavonoids and Microbiotamentioning

confidence: 99%

“…Bifidobacterium has also been associated to a reduced incidence of obesity, while Lactobacillus seems to reduce the severity of inflammatory bowel disease (IBD) 40 . Overall, the presence of these two strands has been linked to better health in general, with a reduction of mood disorders 41 and other conditions 42,43 . Overall, it appears that microbiota modulation impacts inflammation in the organism.…”

Section: Introductionmentioning

confidence: 99%

Luteolin, inflammation and cancer: Special emphasis on gut microbiota

et al. 2021

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Luteolin belongs to the family of flavonoids, which have anti-inflammatory functions, potentially useful in a clinical context, particularly for patients suffering from cancer, neuropsychiatric disorders, inflammatory bowel conditions. This peculiarity has been used for centuries in traditional Chinese medicine, for many different diseases. Its anti-inflammatory effects might be particularly relevant in cancer, with some studies reporting anti-angiogenesis, anti-metastatic, and apoptotic effects on cancer cells by luteolin and other flavonoids. In this article, we analyze the anti-inflammatory role of luteolin, discussing the pathways it may act on. We will then discuss the possible role of microbiota in inflammatory modulation by luteolin. Finally, the possible therapeutic applications of luteolin's anti-inflammatory properties will be analyzed, with a particular focus on cancer.

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The protective effect of Lactobacillus and Bifidobacterium as the gut microbiota members against chronic urticaria

Cited by 32 publications

References 48 publications

Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Patients With Chronic Spontaneous Urticaria

Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Patients With Chronic Spontaneous Urticaria

Probiotic as an adjuvant therapy in chronic urticaria: a blinded randomized controlled clinical trial

Luteolin, inflammation and cancer: Special emphasis on gut microbiota

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