The protective effect of estrogens against spontaneous pancratic islet and renal changes in aging male rats

Hajdu, A.; Róna, G

doi:10.1007/bf02135771

Cited by 13 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, estrogen-exposed cancer cells caused induction of p21 as well as p53 (35). It has been demonstrated that ovarian hormones are protective in the development of renal injury (8,26). Estrogens in vivo are known to act indirectly as potent antioxidants through upregulation of antioxidant genes, including GPx and MnSOD, via the MAP kinase and NF-B pathways (31).…”

Section: Discussionmentioning

confidence: 98%

Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity

Tarry-Adkins

Ozanne

Norden

et al. 2006

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

It is well documented that females live longer than males and more renal damage occurs in males. However, the underlying mechanisms are not fully understood. The aim of this study was to define aging effects on albuminuria and kidney telomere length from male and female rats and to determine mechanisms, which may explain any observed differences. Cellular senescence is known to play a major role in nephropathology, and as such, a range of senescence markers were compared in male and female renal tissue. Oxidative stress has been shown to accelerate telomere shortening and elicit cellular growth arrest. Thus major antioxidants, MnSOD, glutathione peroxidase I, and glutathione reductase, were also evaluated. Urinary albumin excretion increased with age in both sexes, but the increase was greater in males than females. In the cortex and medulla of both male and female rats, age-related telomere shortening occurred, the effect being more pronounced in males than in females. The cortical region had more short telomeres than the medulla in both genders. p53 And p21 expression over time significantly increased in males, but not in females. MnSOD expression was elevated in female vs. male cortex. Gxp1 and glutathione reductase levels were increased in the older female cortex compared with males. Our findings indicate that a reduction in oxidative damage protection may be responsible for accelerated telomere shortening over time, resulting in increased cellular senescence, loss of renal function, and death in male rats.

show abstract

Section: Discussionmentioning

confidence: 98%

Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity

Tarry-Adkins

Ozanne

Norden

et al. 2006

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

show abstract

“…Unilateral nephrectomy and contralateral ligation of two-thirds of the renal circulation produce more rapid increases in proteinuria, segmental glomerulosclerosis, and collagen ␣1 IV mRNA in male rats than in female rats (7). In line with this, estrogen protects male rats against the development of glomerulosclerosis (8). In mesangial cell cultures, estrogen inhibits proliferation, suppresses synthesis of collagen type I and IV, and inhibits the oxidation and uptake of LDL by macrophages (9,10).…”

mentioning

confidence: 79%

Decreases in Renal Functional Reserve and Proximal Tubular Fluid Output in Conscious Oophorectomized Rats

Nielsen¹,

Flyvbjerg²,

Bruun³

et al. 2003

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Abstract. Age-dependent glomerulosclerosis with reduced GFR develops earlier among men than among women. Therefore, whether female sex hormones could prevent the agedependent decrease in GFR was investigated. The kidney function in oophorectomized rats treated with placebo (OOX group), estrogen (OOXϩE 2 group), or estrogen plus progesterone (OOXϩE 2 ϩP group) for 5 mo and in sham-operated rats (sham group) was examined. The rats were 13 mo of age at the time of the investigation. They were conscious and chronically instrumented. The results demonstrated that estrogen, alone or in combination with progesterone, was without effect on the baseline GFR and effective renal plasma flow but prevented severe decreases in the renal functional reserve and fractional proximal tubular fluid output (lithium clearance technique, fractional lithium excretion), which were observed in the OOX group. The renal functional reserve (estimated by stimulation with glycine) was Ϫ223 Ϯ 151, 483 Ϯ 129, 675 Ϯ 76, and 208 Ϯ 140 l/min in the OOX, OOXϩE 2 , OOXϩE 2 ϩP, and sham groups, respectively. Fractional lithium excretion was 12.4 Ϯ 3.1, 26.8 Ϯ 2.0, 31.8 Ϯ 2.5, and 23.6 Ϯ 3.3% in the OOX, OOXϩE 2 , OOXϩE 2 ϩP, and sham groups, respectively. In conclusion, oophorectomy at the age of 8 mo did not produce a decrease in baseline GFR in female rats within a period of 5 mo. However, oophorectomy led to severe decreases in the renal functional reserve and fractional proximal tubular fluid output. Both effects were prevented with administration of estrogen. Sham-operated rats demonstrated values for renal functional reserve and fractional lithium excretion that were between those observed for the OOX group and the groups treated with sex hormones.

show abstract

“…In another experiment, disease progression in male rats could be slowed by estrogen substitution or orchiectomy [22], suggesting a protective influence of estrogens and adverse effects of androgens. Similarly, experimental castration of 5/6 nephrectomized rats protected male animals against proteinuria, tubulointerstitial damage, and renal accumulation of fibronectin, whereas female animals did not show any protective effect after removal of estrogen influence by ovariectomy [23].…”

Section: Influences Of Hormones On Experimental Models Of Renal Functmentioning

confidence: 97%

The influence of gender and sexual hormones on incidence and outcome of chronic kidney disease

et al. 2011

View full text Add to dashboard Cite

It has long been known that the female sex is associated with a better clinical outcome in chronic renal diseases. Although many experimental, clinical, and epidemiological studies in adults have attempted to explain the difference in disease progression between females and males, a definitive understanding of the underlying mechanisms is still lacking. Hormone-modulating therapies are being increasingly used for various indications (such as post-menopausal hormone replacement, estrogen- or androgen-receptor antagonists for cancer therapy). Therefore, a deeper knowledge of the interaction between sexual hormones and progression of kidney disease is important, as hormone-modulating therapy for non-renal indication may influence both kidney structure and function. In addition, specific modulation of the sexual hormone system, such as the use of selective estrogen receptor modulators, may represent a therapeutic option for patients with renal diseases. Although conclusive data on this topic in the pediatric population are still lacking, the aim of this review is to familiarize pediatric nephrologists with gender-specific differences in renal physiology, pathophysiology, and the progression of kidney diseases. Experimental models that analyze the effects of sexual hormones on renal structure and function are discussed. It is hoped that this review will stimulate researchers to focus on pediatric studies that will provide a deeper insight into the interaction of gender hormones and the kidney both before and during puberty.

show abstract

The protective effect of estrogens against spontaneous pancratic islet and renal changes in aging male rats

Cited by 13 publications

References 10 publications

Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity

Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity

Decreases in Renal Functional Reserve and Proximal Tubular Fluid Output in Conscious Oophorectomized Rats

The influence of gender and sexual hormones on incidence and outcome of chronic kidney disease

Contact Info

Product

Resources

About