The Protective Effect of EET on Renal I/R through NLRP3 and Pyroptosis

Abstract

Volume 5 -Issue 4Epoxyeicosatrienoic acids (EETs), metabolized from arachidonic acid through the cytochrome P450 epoxygenases pathway, have such protective effects of vasodilation, anti-inflammation and antiapoptosis in the treatment of multiple diseases [13][14][15]. Our previous evidence showed that EETs can alleviate inflammatory cell infiltration induced by renal I/R [16][17][18]. In this study, male C57/BL6 mice were used to establish I/R-induced AKI model with the pre-administration of 14,15-EET. The expression of NLRP3, cleaved cysteinyl aspartate specific proteinase 1 (cleaved-caspase-1), interleukin-1β (IL-1β) and so on were measured to analyze the effect and mechanism of EET on renal I/R-related inflammatory response, which may be developed a novel and useful treatment to improve AKI.