The protective effect of curcumin against aluminum chloride-induced oxidative stress and hepatotoxicity in rats

Cheraghi, Ebrahim; Roshanaei, Kambiz

doi:10.18502/pbr.v5i1.761

Cited by 22 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, increased enzymatic activity of alkaline phosphatase (ALP) in the blood generally describes primary liver biliary cirrhosis or an alteration of the hepatic architecture [49], since the rise in total bilirubin level might be due to erythrocyte haemolysis or disruption of hepatic function [2]. Remarkable AlCl 3 -induced alterations in biochemical parameters (decreased plasma concentrations of total proteins and albumin and increased AST, ALT and PAL activities) were confirmed by the These results are in line with those previously reported [14,21].…”

Section: Discussionsupporting

confidence: 83%

“…We demonstrated that the decrease in the levels of protein transporters is associated with liver tissue damage, as evidenced by a significant increase in AST, ALT and LDH activity. This finding could support the hepatic histopathological modifications found, resulting in leakage of liver enzymes into the bloodstream following alterations in cell membrane permeability [48,14]. Furthermore, increased enzymatic activity of alkaline phosphatase (ALP) in the blood generally describes primary liver biliary cirrhosis or an alteration of the hepatic architecture [49], since the rise in total bilirubin level might be due to erythrocyte haemolysis or disruption of hepatic function [2].…”

Section: Discussionmentioning

confidence: 79%

“…Liver dysfunction or failure usually leads to health disorders [13]. Al can affect the liver by causing a loss in redox homeostasis, which consequently leads to pro-/antioxidant imbalance resulting in the production of high levels of ROS [9,14]. Al hepatotoxicity is associated with histopathological alterations, including cell necrosis and increased inflammatory cell infiltration [15,1].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

et al. 2021

View full text Add to dashboard Cite

Background This study was designed to evaluate the protective effects of a Rhamnus alaternus aqueous extract (RAAE) on aluminum chloride-induced hepatotoxicity in rats. A preliminary phytochemical study and antioxidant activity tests of the extract were performed. Methods A preliminary phytochemical study and antioxidant activity tests of the extract were performed. For the in vivo study, twenty-four male rats were divided into four groups. The control group (C); the RAAE group treated with 250 mg/kg b.w RAAE; the AlCl3 group, which received 50 mg/kg b.w AlCl3; and the AlCl3/RAAE group that was treated with AlCl3 plus RAAE. Results The RAAE contains several phenolic compounds. This plant extract showed a high radical scavenging effect and high antioxidant activity. Administration of AlCl3 resulted in a significant increase in the activities of aspartate aminotransferase and alanine aminotransferase (AST, ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) and significant decreases in the plasma concentrations of total proteins and albumin. Moreover, AlCl3 induced a hepatic pro-oxidant effect leading to an increase in malonaldehyde (MDA) and carbonyl protein contents, the depletion of the content of reduced glutathione (GSH) and a decrease in the antioxidant enzymatic activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). However, RAAE supplementation with AlCl3 treatment significantly decreased the levels of MDA and carbonyl proteins and markedly restored the activities of the antioxidant enzymes. These results are supported by the improvement in liver tissue restoration. Conclusions The Rhamnus alaternus aqueous extract was shown to have effective antioxidant activity owing to its phenolic compounds protecting against AlCl3-induced liver oxidative damage.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It had been reported that the accumulation of AlC1 3 in the liver tissue is associated with necrosis and degeneration of hepatic tissue to escape of liver enzymes from the injured cells to the plasma (Imam et al, 2016;Yousef, 2004). In addition, histological changes in the liver and the increase of plasma enzyme activities may be due to free radicals production and oxidative stress after AlC1 3 administration in the liver tissue (Abdel-Wahab, 2012; Cheraghi & Roshanaei, 2019). On the other hand, the administration of propolis, AlCl 3 combined with propolis and administration of AlCl 3 for 1 month, and administration of AlCl 3 combined with propolis for another month showed non- no inflammatory cells were detected as compared to aluminum treated group (d).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of propolis against aluminum chloride-induced hepatorenal toxicity in albino rats

Okail

Ibrahim

Badr

2020

JoBAZ

View full text Add to dashboard Cite

Background: The use of natural products is an essential way to new pharmaceutical leads for the discovery and development of new drugs to treat diseases. Propolis (Pro) is a natural resinous product produced by honey bees. It has a strong cytoprotective effect against various exogenous toxic agents. The current study was designed to evaluate the possible protective effect of propolis against the toxicity of aluminum chloride (AlCl 3) on hepatorenal structure and function in male white albino rats. Methods: Thirty mature males of albino rat, Rattus rattus, weighing about 80-90g were divided into five groups contained 6 rats each. The first group acts as a control (received only saline solution); the second group (Al) had given orally 40 mg/kg b.w. of AlC1 3 , the third group (Pro) had administrated orally 150 mg/kg b.w. of propolis and the fourth group (Al+Pro) had given 40 mg/kg b.w. of AlCl 3 in the morning and 150 mg/kg b.w. of propolis in the evening. These four groups had given the treatments for two months. The fifth group (Al-Pro) had given 40 mg/kg b.w. of AlC1 3 chloride for one month then had given 40 mg/kg b.w. of AlCl 3 combined with 150 mg/kg b.w. of propolis for another month. Results: The AlCl 3-treated group showed a significant increase in the activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), acid phosphatase (AP), and lactate dehydrogenase (LDH) in the plasma. Also, glucose, total protein, albumin, creatinine, uric acid, urea, cholesterol, and triglycerides in the plasma were significantly increased. The histological examination for the liver and kidney sections revealed marked histopathological alternations. The treatment with propolis combined with AlCl 3 improved the previous mentioned biochemical and histological alterations induced by AlCl3. Conclusion: It can be concluded that the combination of propolis with AlCl 3 alleviated the toxic effects of AlCl 3. The propolis has protective influences on the hepatorenal structure and function and could be able to resist AlCl 3 intoxication.

show abstract

“…Group II (AlCl 3 group): Rats were received 10 mg/ kg b.w in 0.2 ml of AlCl 3 once daily through oral gavage 14 .…”

Section: Methodsmentioning

confidence: 99%

Impact of Sesame Oil for Abrogating Hepatic Oxidative Stress Actuated by Aluminum Chloride in Male Rats

Enas S. Abdel-Baky

2020

IJPHRD

View full text Add to dashboard Cite

The hepatoprotective effect of sesame oil (SO) was evaluated against aluminum chloride (AlCl 3 ) induced hepatic tissue damage in male rats. A total of twenty four male rats were used and grouped into four groups of six rats each. AlCl 3 induced hepatic tissue damage, marked by increased the activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and bilirubin levels, and a significant decrease in total protein and albumin levels when compared with the normal control. Also, the level of malodealdehyde (MAD) in the liver tissue was significantly increased. Whereas, the activities of superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) enzymes were markedly decreased. Supplementation of AlCl 3 treated rats with SO could improve most of the biochemical alterations. The results of the present study prove that SO has a potent hepatoprotective effect against AlCl 3 induced oxidative stress injury in hepatic tissues of male rats.

show abstract

The protective effect of curcumin against aluminum chloride-induced oxidative stress and hepatotoxicity in rats

Cited by 22 publications

References 0 publications

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

The protective effect of propolis against aluminum chloride-induced hepatorenal toxicity in albino rats

Impact of Sesame Oil for Abrogating Hepatic Oxidative Stress Actuated by Aluminum Chloride in Male Rats

Contact Info

Product

Resources

About