The protective effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in rat ovary

Çelik, Önder; Türköz, Yusuf; Hasçalık, Şeyma; Hascalik, Mehmet; Çiğremiş, Yılmaz; Mızrak, Bülent; Yoloğlu, Saim

doi:10.1016/j.ejogrb.2004.05.007

Cited by 68 publications

(67 citation statements)

References 25 publications

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“…3 and 4). According to Celik et al (2004), MDA is a marker of tissue injury increased levels of it reflect the destruction of unsaturated fatty acids in the cell membrane. In our study, administration of rhEPO significantly reduced the oxidant levels within the ovary (Table 1) a reduction at the levels of MDA, prevented post-ischemic ovarian injury and maintained the ovarian morphology (Fig.…”

Section: Discussionmentioning

confidence: 99%

The Ovario-Protective Effect of Erythropoietin against Oxidative Damage Associated with Reperfusion Following Ovarian Torsion in Rat

Manizheh¹

2011

American Journal of Animal and Veterinary Sciences

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Section: Discussionmentioning

confidence: 99%

The Ovario-Protective Effect of Erythropoietin against Oxidative Damage Associated with Reperfusion Following Ovarian Torsion in Rat

Manizheh¹

2011

American Journal of Animal and Veterinary Sciences

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“…The sections were examined under light microscope independently by a pathologist in a blinded fashion. The pathological changes were graded using a 4-level grading scale [5] as follows: grade 0 = normal ovarian architecture; grade 1 = mild edema, mild vascular congestion, no hemorrhage and no leukocytic infiltration; grade 2 = moderate edema, moderate vascular congestion, no hemorrhage and no leukocytic infiltration; grade 3 = severe edema, severe vascular congestion, minimal hemorrhage and minimal leukocytic infiltration, and grade 4 = severe edema, severe vascular congestion, hemorrhage and leukocytic infiltration.…”

Section: Methodsmentioning

confidence: 99%

“…Tissue damage is affected by the duration of I/R, and detorsioned tissue has local and systemic problems with respect to vitality and functional capacity. Various therapeutic agents have been tested to reduce tissue damage in the case of ovarian I/R injury [2,3,4,5]. However, ovarian function is maintained in the majority of cases (approximately 95%) after detorsion [1].…”

Section: Introductionmentioning

confidence: 99%

Sildenafil Reduces Ischemia-Reperfusion Injury in Rat Ovary: Biochemical and Histopathological Evaluation

Çelik

Aksoy

Aksoy³

et al. 2014

Gynecol Obstet Invest

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Background/Aims: To evaluate the effects of sildenafil on antioxidant enzyme activities, lipid peroxidation and histopathological changes in ovarian tissue after ischemia-reperfusion (I/R) injury in a rat model. Methods: A total of 18 adult female Wistar albino rats weighing 200-250 g were studied as follows: (1) control group: sham operation, (2) I/R group: 3 h of reperfusion after 3 h of ischemia and (3) I/R + sildenafil group: 3 h of reperfusion after 3 h of ischemia; half an hour before reperfusion, sildenafil (1.4 mg·kg^-1) was given by oral gavage. At the end of the reperfusion periods, the ovarian tissues were removed for histopathological examination and to determine malondialdehyde (MDA) levels and glutathione peroxidase, myeloperoxidase (MPO) and superoxide dismutase (SOD) activities. Results: The I/R group had higher ovarian tissue MDA levels than the control group and the IR + sildenafil group (p = 0.016 and p = 0.044, respectively). MPO activity was lower in the IR + sildenafil group compared with the I/R group (p = 0.022). SOD activity was lower in the I/R group compared with the control group and the I/R + sildenafil group (p = 0.030 and p = 0.015, respectively). The I/R + sildenafil group had improved histological appearance which was not different to the control group (p > 0.05). Conclusion: The biochemical and histopathological results of this experimental study demonstrated that I/R injury in the ovary is ameliorated by sildenafil treatment.

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“…There are numerous reports about the beneficial effects of anthocyanins on health and prevention of diseases such as heart disorders by the consumption of fruits rich in anthocyanins (Tsuda et al 1996;Wang & Jiao 2000;Tsuda et al 2002Tsuda et al , 2003. There are investigations about the effects of plant extracts and their compounds on the female reproductive system (Celik et al 2004;Gwehenberger et al 2004;Owolabi et al 2008;Mokhtari et al 2009;Chen et al 2010;Zafari Zangeneh et al 2010;Nogueira et al 2010). The effect of some medicinal plants on mice (Gupta et al 2004;Gan et al 2006;Mokhtari et al 2009;Khazaei et al 2011) and rat (Manneras et al 2010) ovaries have been previously evaluated.…”

Section: Introductionmentioning

confidence: 99%

Effects of intraperitoneal administration of Papaver rhoeas L. extract on mouse ovaries

Golkar‐Narenji

Samadi

Eimani

et al. 2013

Animal Cells and Systems

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This research studies the effect of water-alcohol Papaver rhoeas L. (P. rhoeas) extract on mouse ovaries and in vitro development (IVD) of oocytes. Different dosages of P. rhoeas extract (25, 50, 100, 200 mg/kg body weight) were injected intraperitoneally (i.p.) during a period of 12 days. Following superovulation, the numbers of ovulated oocytes, the rates of in vitro fertilization, IVD and the cellularity of blastocysts were recorded. Additionally, effect of the best dosage on ovarian follicle population and the ability of immature oocytes to mature in vitro were evaluated. Administration of 200 mg/kg significantly increased the percentage of 4Á8 cells, morula and blastocyst embryos compared to the control group (p B0.05). Furthermore, total cellularity of blastocysts was significantly higher with the administration of 200 mg/kg of extract in comparison to control group (p B0.05). Therefore, the most effective dosage was considered to be 200 mg/kg. With the administration of 200 mg/kg no marked changes were observed in the IVM rate of retrieved oocytes from treated group in comparison to control group. Furthermore, the percentage of ovarian follicles was not significantly different when compared to control group. Also, during visual evaluations no abnormal apoptosis was detected in follicles of ovaries treated with 200 mg/kg when compared to control group. Higher IVD and blastocyst cellularity in the group treated with defined dosage of P. rhoeas indicates that the extract affects ovaries in a dose dependent manner. The extract possibly increases the quality of ovulated oocytes and IVD competence of oocytes.

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The protective effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in rat ovary

Cited by 68 publications

References 25 publications

The Ovario-Protective Effect of Erythropoietin against Oxidative Damage Associated with Reperfusion Following Ovarian Torsion in Rat

The Ovario-Protective Effect of Erythropoietin against Oxidative Damage Associated with Reperfusion Following Ovarian Torsion in Rat

Sildenafil Reduces Ischemia-Reperfusion Injury in Rat Ovary: Biochemical and Histopathological Evaluation

Effects of intraperitoneal administration of Papaver rhoeas L. extract on mouse ovaries

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