The protective effect of ascorbic acid and thiamine supplementation against damage caused by lead in the testes of mice

Shan, Guang; Tang, Tian; Zhang, Xiaobin

doi:10.1007/s11596-009-0114-4

Cited by 40 publications

(19 citation statements)

References 20 publications

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“…This caused increased interstitial space and consequently tissue edema [30]. Damaged DNA or increased apoptosis in germinal cells of seminiferous tubules are thought to be one of the effect mechanisms of lead [34,39]. Another mechanism is suppression of hypothalamicpituitary-testicular axis [9].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Adibmoradi¹,

Malekinejad²

2015

Reprod Syst Sex Disord

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Objective: Negative effects of lead on the male reproductive system and sperm fertility parameters have been shown broadly. In recent years, use of medicinal herbs in reducing heavy metal toxicities has increased worldwide. One of these herbals, wheat sprout, contains high amount of vitamins (especially vitamin E), antioxidants and phytoestrogen compounds. This study investigated the effects of wheat sprout extract (WSE) and vitamin E on testicular oxidative stress in rats exposed to lead acetate.Methods: Thirty-five rats were divided randomly into seven groups: G1 (control group) received 1 ml/kg/day of normal saline, G2 received 20 mg/kg/day of lead acetate, G3 and G4 received 100 mg/kg/day and 200 mg/kg/day of WSE respectively, G5 and G6 received 100 mg/kg/day and 200 mg/kg/day of WSE respectively with 20 mg/kg/day of lead acetate, and G7 received 100 mg/kg/day of vitamin E with 20 mg/kg/day of lead acetate. After 35 days, rats were sacrificed and blood, sperm, liver and testicle tissue samples were collected for histomorphological and histochemical studies.Results: Results showed that count, motility and viability of sperms decreased following the administration of lead acetate (P<0.01). Histomorphological studies showed a significant decrease in tubular differentiation index (TDI), spermiogenesis index (SI), repopulation index (RI), number of Leydig and Sertoli cells, and epithelium height and diameter of seminiferous tubules in groups receiving lead acetate (P<0.05). Conclusion:Summary, results of the current study show that dose dependent WSE significantly prevents testicular toxicity and oxidative stress effects of lead acetate.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Adibmoradi¹,

Malekinejad²

2015

Reprod Syst Sex Disord

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“…The effect of risk element uptake on body weight and weight gain of rats was investigated by Paul et al (2002) in the case of arsenic, Asagba (2010) in the case of cadmium, Smith et al (2008) and Shan et al (2009) and in the case of lead. Whereas animal exposure to arsenic and lead did not result in the animal growth suppression regardless of element rate and experiment duration, suppressed animal growth was observed after dietary cadmium exposure of rats.…”

Section: Discussionmentioning

confidence: 99%

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Vlčková¹,

Malinová²,

Koubková³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The long-term accumulation of risk elements (As, Cd, Pb) originated from differently contaminated soils in rat organism was investigated during a model two-generation experiment. The effect of soil contamination level, gender, and length of exposure as well as the interactions between risk elements and selected essential macro-and microelements were studied. Rat diet contained 10% of individual soils (based on dry weight): (i) Fluvisol heavily polluted by As, Cd, Zn, and Pb, (ii) Luvisol contaminated by As, Cd, and Zn, and (iii) uncontaminated Chernozem. Male and female Wistar rats used for the experiment were housed in cages in a room with controlled temperature for 60 days and were fed ad libitum the mentioned diets. Subsequently, the pregnant females were continuously fed the experimental diet until weaning when the young animals were separated to male and female and fed the experimental diet till day 110 of age. The element contents in rat tissues reflected the risk element contents in contaminated soils. The bioaccessibility and bioavailability of the risk elements decreased in the order Cd>As>Pb and was affected by the soil physicochemical parameters. No significant differences were observed between male and female rats as well as between the first and the second generation. However, interactions were reported among the risk elements where the high cadmium content in Fluvisol resulted in increasing arsenic accumulation in the rat liver. Moreover, arsenic-copper interactions were observed where significant increase of the copper level was determined in kidney of the animals fed Luvisol exceeding 50-fold the maximum permissible limits for As content in agricultural soils. Among the hematological and biochemical characteristics of rats, total erythrocyte count (Er), hematocrit (Hct) increased confirming adverse effect of soil-derived risk elements especially in male rats.

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“…They reported that introduction of ascorbic acid during pregnancy and lactation caused to some extent amelioration of oxidative stress in the developing hippocampus. Shan et al (2009) examined the defensive effects of ascorbic acid and thiamine against the toxic effects of lead on testes of mice. Exposure to lead exhibited a significant decrease in epididymal sperm count and motility, along with the induction of apoptosis through activation of caspase-3, Fas/Fas-L and Bcl-2.…”

Section: Vitaminsmentioning

confidence: 99%

Toxicity of lead: a review with recent updates

Flora¹,

Gupta²,

Tiwari³

2012

Interdisciplinary Toxicology

1,712

1,030

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Lead poisoning has been recognized as a major public health risk, particularly in developing countries. Though various occupational and public health measures have been undertaken in order to control lead exposure, cases of lead poisoning are still reported. Exposure to lead produces various deleterious effects on the hematopoietic, renal, reproductive and central nervous system, mainly through increased oxidative stress. These alterations play a prominent role in disease manifestations. Modulation of cellular thiols for protection against reactive oxygen species (ROS) has been used as a therapeutic strategy against lead poisoning. N-acetylcysteine, α-lipoic acid, vitamin E, quercetin and a few herbal extracts show prophylaxis against the majority of lead mediated injury in both in vitro and in vivo studies. This review provides a comprehensive account of recent updates describing health effects of lead exposure, relevant biomarkers and mechanisms involved in lead toxicity. It also updates the readers about recent advances in chelation therapy and newer therapeutic strategies, like nanoencapsulation, to treat lead induced toxic manifestations.

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The protective effect of ascorbic acid and thiamine supplementation against damage caused by lead in the testes of mice

Cited by 40 publications

References 20 publications

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Toxicity of lead: a review with recent updates

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