The protective effect of apelin on ischemia/reperfusion injury

Yang, Yanjie; Lv, Shuangyu; Lyu, Shuang-Kun; Wu, Dongdong; Chen, Qiang

doi:10.1016/j.peptides.2014.11.001

Cited by 46 publications

(26 citation statements)

References 36 publications

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“…We did not identify any side effects to ML221 treatment in our xenograft model, however, since apelin signaling also regulated blood pressure and cardiac activity, it is possible significant side effects could develop in more advanced therapeutic trials. Furthermore, apelin signaling has been shown to be organ protective in specific circumstances such as cardiac ischemia/reperfusion injury and hemorrhagic shock [57,58]. Additionally, Chen et al demonstrated that intranasal apelin treatment following an ischemic stroke was neuroprotective and induced angiogenesis in mice [59].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth

et al. 2017

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Purpose Cholangiocarcinoma (CCA) is a malignancy of the biliary epithelium that is associated with low five-year survival. The apelin receptor (APLNR), which is activated by the apelin peptide, has not been studied in CCA. The purpose of this study is to determine if inhibition of the apelin/APLNR axis can inhibit CCA growth. Methods Immunohistochemistry, rtPCR, immunofluorescence, flow cytometry, and ELISA was used to measure APLNR expression in human CCA cells and tissues. Mz-ChA-1 cells were treated with increasing concentrations of apelin and ML221, an APLNR antagonist. Expression of proliferative and angiogenic genes were measured via rtPCR. In vivo, Mz-ChA-1 cells were injected into the flanks of nu/nu mice, which were treated with ML221 (150 μg/kg) via tail vein injection. Results Expression of the apelin/APLNR axis was increased in CCA. In vitro, CCA proliferation and angiogenesis was inhibited by ML221 treatment. ML221 treatment significantly decreased tumor growth in nu/nu mice. Conclusion The apelin/APLNR axis regulates CCA proliferation and angiogenesis. Inhibition of the apelin/APLNR axis decreases tumor growth in our xenograft model. Targeting APLNR signaling has the potential to serve as a novel, tumor directed therapy for CCA.

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Section: Discussionmentioning

confidence: 99%

Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth

et al. 2017

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“…However, the signaling mechanisms underlying these effects are still under investigation. Apelin appears also to have cardio-protective effects against ischemia/reperfusion injury, similarly to adenosine (Yang et al, 2014). Interestingly, apelin has been shown to exert positive inotropy in rat hearts in vitro (Szokodi et al, 2012).…”

Section: Apelin Receptormentioning

confidence: 99%

GPCR signaling and cardiac function

Capote

Perez

Lymperopoulos

2015

European Journal of Pharmacology

127

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“…Recently, researchers have increasingly focussed on the effect of the apelin/APJ system on ischemia/reperfusion (I/R) injury (Chen, Wu, Li, & Chen, ; Y. Yang, Lv, Lyu, Wu, & Chen, ). The pathophysiology of I/R injury is extremely complex, including vascular endothelial cells, leukocytes, oxygen radicals, inflammatory mediators such as platelet‐activating factor and tumor necrosis factor, and adhesion molecules (Sagiroglu et al, ).…”

Section: The Role Of Apelin/apj System In Digestive System Diseasesmentioning

confidence: 99%

“…Apelin could activate multiple protective mechanisms to prevent the heart, brain, liver, and kidney I/R injury (Y. Yang et al, 2015). Similarly, apelin is also studied in the ischemia and reperfusion of the digestive system.…”

Section: Intestinal Ischemia/reperfusion Injurymentioning

confidence: 99%

Function and regulation of apelin/APJ system in digestive physiology and pathology

Huang

Luo

Liu

et al. 2018

Journal Cellular Physiology

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Apelin is an endogenous ligand of seven‐transmembrane G‐protein‐coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, liver, kidney, and gastrointestinal tract and even in tumor tissues. Studies show that apelin messenger RNA is widely expressed in gastrointestinal (GI) tissues, including stomach and small intestine, which is closely correlated with GI function. Thus, the apelin/APJ system may exert a broad range of activities in the digestive system. In this paper, we review the role of the apelin/APJ system in the digestive system in physiological conditions, such as gastric acid secretion, control of appetite and food intake, cell proliferation, cholecystokinin secretion and histamine release, gut–brain axis, GI motility, and others. In pathological conditions, the apelin/APJ system plays an important role in the healing process of stress gastric injury, the clinical features and prognosis of patients with gastric cancers, the reduction of inflammatory response to enteritis and pancreatitis, the mediation of liver fibrogenesis, the promotion of liver damage, the inhibition of liver regeneration, the contribution of splanchnic neovascularization in portal hypertension, the treatment of colon cancer, and GI oxidative damage. Overall, the apelin/APJ system plays diversified functions and regulatory roles in digestive physiology and pathology. Further exploration of the relationship between the apelin/APJ system and the digestive system will help to find new and effective drugs for treating and alleviating the pain of digestive diseases.

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The protective effect of apelin on ischemia/reperfusion injury

Cited by 46 publications

References 36 publications

Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth

Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth

GPCR signaling and cardiac function

Function and regulation of apelin/APJ system in digestive physiology and pathology

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