The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction

Ramesh, R.; Murugaiyan, Sathish Babu; Gopal, Niranjan; Shalini, Rachel

doi:10.7860/jcdr/2013/5524.2947

Cited by 9 publications

(9 citation statements)

References 8 publications

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“…20 Serum magnesium was determined using flame atomic absorption spectrophotometer; (AA-630-12) (Schimadzu Europe, GmbH, Albert-Hahn-Strasse 6-10, Germany. 21 The reference range of Mg was 1.6-2.6 mg/dl.…”

Section: Ethical Aspectsmentioning

confidence: 99%

Magnesium in type 2 diabetes mellitus and its correlation with glycemic control

Sadik

EL-Ghaffar

2015

Int J Res Med Sci

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Section: Ethical Aspectsmentioning

confidence: 99%

Magnesium in type 2 diabetes mellitus and its correlation with glycemic control

Sadik

EL-Ghaffar

2015

Int J Res Med Sci

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“…Chloride ion had no significant value in this study as similar as to Mati E et al, study. 10,11 The decrease in potassium level is common in hypertensive patients of AMI. Present study showed that there is increase of potassium level in hypertensive patients when compared with non-hypertensive p-value = 0.05.…”

Section: Discussionmentioning

confidence: 99%

Electrolyte dysfunction in myocardial infarction patients

Basavaraj

2018

Int J Adv Med

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Background: Myocardial Infarction (MI) is the term given for a state of myocardial necrosis which is secondary to an acute interruption of the coronary blood supply. Severity is dependent on level of occlusion, length of time of occlusion and presence or absence of collateral circulation. Myocardial infarction is now considered part of a spectrum referred to as acute coronary syndrome. It is a spectrum of acute myocardial ischemia that also includes unstable angina (STEMI) and non-ST segment elevation myocardial infarction (NSTEMI). The changes in serum electrolytes were studied in this study with a special focus on sodium and potassium serum levels in patients suffering from AMI. Hence, the aim of the study was to examine the changes in serum electrolytes among AMI patients and then comparison was done with the healthy persons.Methods: The study comprised of 80 subjects, which were divided equally into study group and control group. The study group comprised cases of confirmed diagnosis of recent onset of AMI. Clinical data was collected using interviewing questionnaires. The blood samples of both groups were analysed for serum electrolytes (Na+, K+, Cl-, Ca+ and Mg+) with the help of ion sensitive electrode analyser along with quality control sera.Results: There was statistically significant decrease in sodium and potassium levels in AMI patients. It was found that there was decrease in sodium serum levels in AMI patients suffering with hypertension. Potassium levels were increased in AMI patients suffering from Diabetes Mellitus and Hypertension, which was found to be statistically significant.Conclusions: Hyponatremia and hypokalemia are indicators of acute myocardial infarction. Serum sodium and potassium levels are prognostic indicators, i.e., rise in sodium levels after initial fall was indicative of clinical improvement. Therefore, estimation of sodium and potassium level in acute MI patients can help assess their prognosis.

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“…However, cardiac arrest, cardiac failure, myocardial infarction, Parkinson's syndrome and prostate enlargement were detected for the first time when the signal detection methods were used. The exact mechanism of heart disease by imipenem is not clear, but electrolyte exchange, a known ADR of imipenem, is a significant adjuvant marker of acute myocardial infarction 22. Furthermore, seizure, a serious ADR of imipenem, is associated with an increased risk of sudden cardiac death,23 and bradycardia or tachycardia is included in the drug label information in some countries.…”

Section: Discussionmentioning

confidence: 99%

Signal Detection of Imipenem Compared to Other Drugs from Korea Adverse Event Reporting System Database

et al. 2017

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PurposeTo detect signals of adverse drug events after imipenem treatment using the Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database (KIDS-KD).Materials and MethodsWe performed data mining using KIDS-KD, which was constructed using spontaneously reported adverse event (AE) reports between December 1988 and June 2014. We detected signals calculated the proportional reporting ratio, reporting odds ratio, and information component of imipenem. We defined a signal as any AE that satisfied all three indices. The signals were compared with drug labels of nine countries.ResultsThere were 807582 spontaneous AEs reports in the KIDS-KD. Among those, the number of antibiotics related AEs was 192510; 3382 reports were associated with imipenem. The most common imipenem-associated AE was the drug eruption; 353 times. We calculated the signal by comparing with all other antibiotics and drugs; 58 and 53 signals satisfied the three methods. We compared the drug labelling information of nine countries, including the USA, the UK, Japan, Italy, Switzerland, Germany, France, Canada, and South Korea, and discovered that the following signals were currently not included in drug labels: hypokalemia, cardiac arrest, cardiac failure, Parkinson's syndrome, myocardial infarction, and prostate enlargement. Hypokalemia was an additional signal compared with all other antibiotics, and the other signals were not different compared with all other antibiotics and all other drugs.ConclusionWe detected new signals that were not listed on the drug labels of nine countries. However, further pharmacoepidemiologic research is needed to evaluate the causality of these signals.

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The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction

Cited by 9 publications

References 8 publications

Magnesium in type 2 diabetes mellitus and its correlation with glycemic control

Magnesium in type 2 diabetes mellitus and its correlation with glycemic control

Electrolyte dysfunction in myocardial infarction patients

Signal Detection of Imipenem Compared to Other Drugs from Korea Adverse Event Reporting System Database

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