The Prophylactic Efficacy of Rifampicin-Soaked Graft in Combination with Systemic Vancomycin in the Prevention of Prosthetic Vascular Graft Infection: An Experimental Study

Saçar, Mustafa; Gökşin, İbrahim; Baltalarlı, Ahmet; Turgut, Hüseyin; Saçar, Suzan; Önem, Gökhan; Özcan, Vefa; Adalı, Fahri

doi:10.1016/j.jss.2005.05.017

Cited by 19 publications

(11 citation statements)

References 35 publications

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“…14 Delivering a concentrated topical dose of antibiotic is the basis of antibiotic-bonded grafts, and this method has been illustrated in many studies. [15][16][17][18][19] Shue et al 15 demonstrated that antibiotic-bonded Dacron implants are highly resistant to infection, with a similar description outlined by Torsello et al 16 One animal model study demonstrated that gelatin-sealed vascular grafts prebonded with antibiotics were more resistant to S aureus. 17 In other studies, rifampicin-soaked grafts showed more resistance to methicillin-resistant S epidermidis.…”

Section: Discussionmentioning

confidence: 87%

Antibiotic-loaded polymethylmethacrylate beads for the treatment of extracavitary vascular surgical site infections

Stone

Mousa

Hass

et al. 2012

Journal of Vascular Surgery

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Antibiotic-loaded PMMA beads may serve as an adjunct in the management of VSSIs and may also expand treatment options for graft preservation or in situ reconstruction, with expected recurrent infection rate approaching 20%. Further experience with this adjunct may help elucidate its role in the management of this complicated problem, including the need for bead exchanges, until perigraft cultures are free of microbes.

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Section: Discussionmentioning

confidence: 87%

Antibiotic-loaded polymethylmethacrylate beads for the treatment of extracavitary vascular surgical site infections

Stone

Mousa

Hass

et al. 2012

Journal of Vascular Surgery

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“…CHD is a complex disease related to multiple environmental factors and multiple genes (Zhang et al, 2013). The risk factors of CHD include tobacco (Sacar et al, 2005), excessive alcohol consumption (Wakabayashi, 2013), and unhealthy diet (Ma et al, 2010). These environmental factors may lead to CHD through their impact on epigenetic changes in CHD-related genes (Jiang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population

Ye¹,

Li²,

Hong³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. PPARD encodes peroxisome proliferator-activated receptor delta, which has been shown to play an important role in controlling lipid metabolism and atherosclerosis. In this case-control study, we explored the relationship between PPARD rs2016520 polymorphism and coronary heart disease (CHD) in a Han Chinese population. A total of 657 CHD cases and 640 controls were included in the association study. rs2016520 polymorphism genotyping was performed using the melting temperature-shift polymerase chain reaction method. The PPARD rs2016520-G allele reduced CHD risk by 17.9% (χ 2 = 5.061, In contrast, meta-analysis of PPARD rs2016520 among 3732 cases and 5042 controls revealed no association between PPARD rs2016520 and CHD (P = 0.19). We found that the PPARD rs2016520-GG genotype decreased CHD risk in a Han Chinese population. Moreover, we found an association between serum highdensity lipoprotein cholesterol level and PPARD rs2016520 in senior individuals aged ≥ 65 years. The meta-analysis revealed no association between PPARD rs2016520 and CHD, suggesting ethnic differences in the association between the PPARD locus and CHD.

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“…Although many prosthetic graft materials are used in vascular surgery, we preferred to choose Dacron in this study because of its lower resistance to bacterial adherence compared to polytetrafluoroethylene [9,10,30].…”

Section: Discussionmentioning

confidence: 99%

“…Prior experimental studies have shown that rifampicin-bonded grafts in combination with intravenous antibiotics provided more protection from bacterial contamination than from the use of systemic or local prophylaxis alone [9,32].…”

Section: Discussionmentioning

confidence: 99%

“…Previously, we investigated the effects of intraperitoneal teicoplanin and vancomycin, alone or in combination with rifampicinsoaked grafts, against methicillin-resistant S. epidermidis. Our group was able to demonstrate the efficacy of these antibiotics and optimal routes of administration for in the prevention of vascular graft infections [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Linezolid Alone and in Combination with Rifampicin Prevents Experimental Vascular Graft Infection Due to Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis

Saçar

Kaleli

et al. 2007

Journal of Surgical Research

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The Prophylactic Efficacy of Rifampicin-Soaked Graft in Combination with Systemic Vancomycin in the Prevention of Prosthetic Vascular Graft Infection: An Experimental Study

Cited by 19 publications

References 35 publications

Antibiotic-loaded polymethylmethacrylate beads for the treatment of extracavitary vascular surgical site infections

Antibiotic-loaded polymethylmethacrylate beads for the treatment of extracavitary vascular surgical site infections

Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population

Linezolid Alone and in Combination with Rifampicin Prevents Experimental Vascular Graft Infection Due to Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis

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