Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population

Ye, H D; Li, Y R; Hong, Qingxiao; Zhou, Ang; Zhao, Qiqi; Liu, Xu; Xu, Mingqing; Xu, Xijin; Tang, Linlin; Dai, Dongjun; Jiang, Danjie; Huang, Yi; Wang, D W; Duan, Shiwei

doi:10.4238/2015.june.11.10

Cited by 8 publications

(8 citation statements)

References 37 publications

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“…In contrast, association between the SNP and higher HDL values has been reported in Scottish and Canadian studies [27,28]. No relation was found with SBP in this study, while others have related the minor allele with lower blood pressure in Chinese population [32,68].…”

Section: Discussioncontrasting

confidence: 97%

Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico

Carrillo-Venzor

Erives-Anchondo

Moreno-González

et al. 2020

Genes

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Peroxisome proliferator-activated receptors (PPARs) play roles in glucose and lipid metabolism regulation. Pro12Ala PPAR-γ2 and +294T/C PPAR-δ have been associated with dyslipidemia, hyperglycemia and high body mass index (BMI). We compared metabolic traits and determined associations with Pro12Ala PPAR-γ2 or +294T/C PPAR-δ polymorphism among teenagers from different ethnicity. Four hundred and twelve samples with previous biochemical and biometric measurements were used. Genomic DNA from peripheral blood was extracted and analyzed by end-point PCR for Pro12Ala PPAR-γ2. The +294T/C PPAR-δ PCR product was also digested with Bsl I. Two genotype groups were formed: major allele homozygous and minor allele carriers. Pro12Ala PPAR-γ2 G minor allele frequencies were: 10% in Mestizo-1, 19% in Mestizo-2, 23% in Tarahumara, 12% in Mennonite, and 17% in the total studied population. The +294T/C PPAR-δ C minor allele frequencies were: 18% in Mestizo-1, 20% in Mestizo-2, 6% in Tarahumara, 13% in Mennonite, and 12% in the total studied population. Teenagers with PPAR-γ2 G allele showed a greater risk for either high waist/height ratio or low high-density lipoprotein; and, also had lower total cholesterol. Whereas, PPAR-γ2 G allele showed lower overweight/obesity phenotype (BMI Z-score) frequency, PPAR-δ C allele was a risk factor for it. Metabolic traits were associated with both PPAR polymorphisms.

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Section: Discussioncontrasting

confidence: 97%

Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico

Carrillo-Venzor

Erives-Anchondo

Moreno-González

et al. 2020

Genes

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“…In mice, expression of PPARδ is related to prognosis and metastatic ability of breast cancer cells 38 . Polymorphisms of PPARD and PPARG are associated with risk and prognosis of many diseases, including cardiovascular disease, diabetes, brain diseases, medulloblastoma and other cancers [39][40][41] . In our study, we firstly observed that PPARD polymorphisms (rs2016520, rs67056409 and rs1053049) were significantly associated with glioma risk.…”

Section: Discussionmentioning

confidence: 99%

The Impact of PPARD and PPARG Polymorphisms on Glioma Risk and Prognosis

Ding

Han

Yuan

et al. 2020

Sci Rep

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Recent studies showed that peroxisome proliferator-activated receptors (PPARs) had effects on the progression of multiple tumors, but the role of PPARD and PPARG in glioma remains poorly understand. We conducted a case-control study to investigate the association of polymorphisms in PPARD and PPARG with glioma risk and prognosis in the chinese Han population. Seven polymorphisms (PPARD: rs2016520, rs67056409, rs1053049 and rs2206030; PPARG: rs2920503, rs4073770 and rs1151988) were genotyped using the Agena MassARRAY system in 568 glioma patients and 509 healthy controls. The odd ratios (OR) and 95% confidence interval (CI) were calculated to assess the association of PPARD and PPARG polymorphisms with glioma risk. the Multifactor dimensionality reduction (MDR) method was used to analysis interactions of genetic polymorphisms on glioma risk. then, we conducted log-rank test, Kaplan-Meier analysis and cox regression model to evaluate the relationship of PPARD and PPARG polymorphisms with glioma prognosis. We found PPARD polymorphisms (rs2016520, rs67056409, rs1053049) were significantly associated with glioma risk in multiple models (P < 0.05). Stratified analysis showed rs2016520, rs67056409, rs1053049 of PPARD significantly decreased risk of glioma in the subgroup of age > 40 and astrocytoma (P < 0.05). For male, PPARD rs1053049 had a strong relationship with glioma risk in allele (P = 0.041), dominant (P = 0.040) and additive (P = 0.040) models. The effect of PPARG rs2920503 on glioma risk was related to glioma grade (P < 0.05). MDR showed that a seven-locus model was the best polymorphisms interaction pattern. Moreover, surgery and chemotherapy had strongly impact on overall survival and progression free survival of glioma patients. Our findings suggested that PPARD and PPARG polymorphisms were associated with glioma risk and prognosis in the Chinese Han population, and further studies are need to confirm our results.Glioma is the most common type of malignant brain tumors in the central nervous system (CNS), accounting for approximately 80% of primary brain tumors 1 . The incidence of brain cancer is the highest in European (5.5/100,000 persons), North America (5.3/100,000 persons), Australia (5.3/100,000 persons), Western Asia (5.2/100,000 persons) and Northern Africa (5.0/100,000 persons) 2 . In China, there were 1,016,000 newly diagnosed cases of brain and CNS tumor in 2015 3 . Glioma occurs varied in age, sex, race, histologic type and geographic characteristics 4 . And, glioma has poor overall survival (OS), with less than 5 year survival of patients after diagnosis 5 . The etiology of glioma is multifactorial, which is the results of environmental exposure and genetic factors 4 . Single nucleotide polymorphism (SNP) is the most studied mutations involved in genetic predisposition of glioma. Recently, increasing studies are focused on the role of Peroxisome proliferator-activated receptors (PPARs) polymorphisms on cancer.PPARs is a subfamily of nuclear receptor transcription factors and consists three iso...

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“…Several SNPs in PPARD, including rs2016520 and rs9794, were found to be associated with CVDs [1,7]. In addition, the PPARD SNP rs2016520 (+294C) seemed to be significantly associated with cholesterol metabolism and the risk of CAD [11,26].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been shown that LncPPARD regulates the expression of neighboring protein-coding genes. PPARD, with its direct target genes ADRP and ANGPTL4 , might serve as a novel biomarker for CAD, particularly when combined with risk factors [9,10], since the positive association between PPARD polymorphism rs2016520 and CAD had previously been reported [11]. In this study, three novel polymorphic variants located in the intron of PPARD, namely, rs3777744, rs3798343, and rs6922548, were selected to further investigate the genetic mechanisms by which PPARD impacts the prevalence of CAD.…”

Section: Introductionmentioning

confidence: 99%

The association between peroxisome proliferator-activated receptor Δ rs3777744, rs3798343, and rs6922548 and coronary artery disease

et al. 2019

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Objective: The aim of the present study is to investigate the association between the single nucleotide polymorphism (SNP) sites of peroxisome proliferator-activated receptor Δ (PPARD) and the risk of coronary artery disease (CAD). To this end, a prospective observational single-center study of the clinical data from 880 subjects in a Chinese population was conducted. Methods: A total of 880 subjects, including 609 CAD patients and 271 control subjects, were selected for the present study. All inpatients had 4 ml of venous blood drawn after 12 h of fasting, and then clinical tests were conducted to obtain the biochemical parameters. CAD patients and Controls were distinguished by coronary angiography. Statistical analysis was conducted with SPSS software (ver 16.0). Results: A significant association between the G-alleles of PPARD rs3777744 and rs3798343 and a decreased risk for CAD was found. Moreover, we found an interaction between high fasting high-density lipoprotein cholesterol (HDL-C) serum levels, low serum glucose levels and their genotypes, ultimately decreasing the risk of CAD. Haplotype analysis was conducted on the three SNP sites, rs3777744 and rs3798343 to form a block [r2 = 0.79, D′ = 0.99). The A-C haplotypes were associated with an increased risk of CAD (odds ratio (OR), 95% confidence interval (CI): 1.321 (1.060–1.647), P=0.013], and the G-G haplotypes were associated with a decreased risk [OR, 95% CI: 0.714 (0.567–0.849), P=0.004]. Conclusions: Our study indicates a significant association between the G-alleles of PPARD rs3777744 and rs3798343 and a decreased CAD risk. In addition, genotypes interact with high serum HDL-C levels and low serum glucose levels, resulting in decreased prevalence of CAD.

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Positive association between PPARD rs2016520 polymorphism and coronary heart disease in a Han Chinese population

Cited by 8 publications

References 37 publications

Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico

Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico

The Impact of PPARD and PPARG Polymorphisms on Glioma Risk and Prognosis

The association between peroxisome proliferator-activated receptor Δ rs3777744, rs3798343, and rs6922548 and coronary artery disease

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