The Proper Diet and Regular Physical Activity Slow Down the Development of Parkinson Disease

Abstract

From year to year, we know more about neurodegeneration and Parkinson’s disease (PD). A positive influence of various types of physical activity is more often described in the context of neuroprotection and prevention as well as the form of rehabilitation in Parkinson’s patients. Moreover, when we look at supplementation, clinical nutrition and dietetics, we will see that balancing consumed products and supplementing the vitamins or minerals is necessary. Considering the biochemical pathways in skeletal muscle, we may see that many researchers desire to identify molecular mediators that have an impact through exercise and balanced diet on human health or development of the neurodegenerative disease. Therefore, it is mandatory to study the potential mechanism(s) related to diet and factors resulted from physical activity as molecular mediators, which play a therapeutic role in PD. This review summarizes the available literature on mechanisms and specific pathways involved in diet-exercise relationship and discusses how therapy, including appropriate exercises and diet that influence molecular mediators, may significantly slow down the progress of neurodegenerative processes. We suggest that a proper diet combined with physical activity will be a good solution for psycho-muscle BALANCE not only in PD but also in other neurodegenerative diseases.

Mobile health technology, exercise adherence and optimal nutrition post rehabilitation among people with Parkinson’s Disease (mHEXANUT) – a randomized controlled trial protocol

“…Nevertheless, the nutritional guidelines for people with PD focuses on early detection of nutritional problems, advice for common nutritional challenges and maintenance or improvement of physical function [ 38 , 39 ]. In addition, optimal nutrition and dietary habits can positively affect the effectiveness of PD medications and potentially slow down disease development [ 40 ], as well as improve symptom management and overall well-being [ 39 , 40 ].…”

“…The combination of nutrition and exercise has been shown to improve health outcomes, and interventions combining both is found to have better effects than either one alone in other populations [ 75 – 77 ]. This combination has not yet been studied in the PD population, but it is suggested that it has the potential to slow down the progression of the disease [ 40 ]. A focus on self-management with a comprehensive approach is both desired [ 50 , 78 ] and recommended for future research in this area [ 49 , 79 ].…”

The Role of Diet and Dietary Patterns in Parkinson’s Disease

“…One approach to studying the development of PD is to explore factors associated with increased PD risk. For instance, several factors contribute to the risk of developing PD, including genetics, biological sex, environmental exposures, and lifestyle [ 47 , 48 , 49 , 50 ]. As a result, modifiable risk factors serve as potential targets for attenuating an individual’s risk.…”

Fatores associados ao nível de atividade física e comportamento sedentário de pessoas com doença de parkinson: revisão sistemática e meta-análise

“…Ainda, atividades gratificantes aumentam os níveis de dopamina, já que a dopamina está relacionada com o ganho de recompensa, e esse aumento promove melhor aprendizagem ou reaprendizagem. Por fim, pessoas em estágios iniciais da doença tendem a se beneficiar mais de atividades físicas, já que sua progressão se torna mais lenta (ALONSO-FRECH; SANAHUJA; RODRIGUEZ, 2011;CHROMIEC et al, 2021;ELLIS, T.;MOTL, 2013;FOX et al, 2006).…”