The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody

Han, Qianqian; Jin, Wei; Xiao, Zhifeng; Ni, Hongbin; Wang, Jinhuan; Kong, Jie; Wu, Jun; Liang, Wei; Chen, Lei; Zhao, Yannan; Chen, Bing

doi:10.1016/j.biomaterials.2010.08.040

Cited by 119 publications

(101 citation statements)

References 36 publications

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“…In our previous study, the NeuroRegen scaffold was prepared from bovine aponeurosis, which mainly consists of linearly ordered collagen fibers. When the scaffold was transplanted into complete SCI rat and canine models, it successfully guided neurite outgrowth along its fibers and decreased scar formation (Fan et al, 2010;Han et al, 2009;Han et al, 2010;Han et al, 2015;Li et al, 2013;Lin et al, 2006). Based on these preclinical results, the clinical study was approved by the ethics committee and registered on the National Institute of Health database.…”

Section: Discussionmentioning

confidence: 99%

“…The NeuroRegen scaffold bridges the gap of the lesion and acts as a vehicle to deliver stem cells or biomolecules to promote neural regeneration. In our previous study, a functional biomaterial consisting of NeuroRegen scaffold, biologically active molecules (neurotrophic factors or antagonists to myelin-associated inhibitors), and stem cells was developed that greatly promoted neural regeneration and functional recovery in SCI animals (Han et al, 2010;Han et al, 2015;Li et al, 2015;Li et al, 2013). In future work, biologically active molecules or stem cells could be added to the NeuroRegen scaffold for clinical SCI repair.…”

Section: Discussionmentioning

confidence: 99%

“…In the past 10 years, the NeuroRegen scaffold has been used to deliver multiple functional molecules such as neurotropic factors and antibodies to the injured site in SCI animal models. Newborn neurons, electrical conductivity, re-myelination, and motor function recovery were observed in both rat and canine SCI models (Han et al, 2009;Han et al, 2010;Han et al, 2015;Lin et al, 2006). The NeuroRegen scaffold product standard has been established and the third party inspection of safety evaluation by the National Institute of Food and Drug Control has been completed in order to lay the foundation for the clinical study.…”

Section: Introductionmentioning

confidence: 99%

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One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients

Xiao

Tang

et al. 2016

Sci. China Life Sci.

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The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, NeuroRegen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5-4.5 cm were surgically resected in five complete chronic spinal cord injury (SCI) patients. The NeuroRegen scaffold along with autologous bone marrow mononuclear cells (BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or NeuroRegen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials (SSEP) from the lower limbs was also detected. The results indicate that scar resection and NeuroRegen scaffold transplantation could be a promising clinical approach to treating SCI.NeuroRegen scaffold, chronic spinal cord injury, scar resection, collagen scaffold transplantation, bone marrow mononuclear cells, tissue regeneration Citation:Xiao, Z., Tang, F., Tang, J., Yang, H., Zhao, Y., Chen, B., Han, S., Wang, N., Li, X., Cheng, S., Han, G., Zhao, C., Yang, X., Chen, Y., Shi, Q., Hou, S., Zhang, S., and Dai, J. (2016). One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients. Sci China Life Sci 59, 647 -655.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients

Xiao

Tang

et al. 2016

Sci. China Life Sci.

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“…It was observed that collagen scaffolds is a suitable nerve guidance material (Han et al, 2010) Most collagen nerve guides are engineered from crosslinked collagen with tubular shape such as commercially available NeuraGen® from Integra™. Recent tissue engineering strategies involve addition of neurotrophic factors into collagen scaffolds (Sun et al, 2007;Sun et al, 2009) and cell delivery (Bozkurt et al, 2009;Kemp et al, 2009) in order to attempt to enhance nerve guides.…”

Section: Nerve Repairingmentioning

confidence: 99%

Collagen-Based Drug Delivery Systems for Tissue Engineering

Albu¹,

Titorencu²,

Ghica³

2011

Biomaterials Applications for Nanomedicine

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“…5 This collagen scaffold-CBD-BDNF complex (CSCB) had much better recovery, such as reducing cystic cavity, and extending axonal growth, compared with only collagen scaffold treatment. 5,6 It is important to test CSCB therapy in large animals or non-human primates SCI before clinical trial. 7,8 From the anatomical and physiological perspective, non-human primates are good candidates for SCI model, but high expense and difficult post-surgery care preclude their popularization.…”

Section: Introductionmentioning

confidence: 99%

The collagen scaffold with collagen binding BDNF enhances functional recovery by facilitating peripheral nerve infiltrating and ingrowth in canine complete spinal cord transection

et al. 2014

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Objectives: The aim of this study was to determine the therapeutic effects of a collagen scaffold-collagen binding brain-derived neurotrophic factor (CBD-BDNF) complex (CSCB) on behavioral, electrophysiological and histological improvements in canine complete spinal cord transection model. Methods: A total of 24 adult female beagle dogs received a complete spinal cord transection at the T12 level in three groups, including SHAM group (n = 8), CTL group (complete spinal cord transection without any treatment, n = 8) and CSCB group (complete spinal cord transection with CSCB, n = 8).Results: CSCB therapeutic group showed markedly functional recovery by Olby score and spinal somatosensory evoked responses (SSERs) assay at 12 weeks after complete spinal cord transection. Furthermore, numerous peripheral myelinated axons aligned parallel to the long axis of the spinal cord were detected in CSCB group dogs. In stark contrast, the injured site was dominated by fibrous and only scattered axons were detected in the edge of spinal cord in CTL group dogs. Conclusion: The CSCB has an evident therapeutic effect by facilitating peripheral nerve infiltrating following the severe spinal cord injury in canine animals.

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The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody

Cited by 119 publications

References 36 publications

One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients

One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients

Collagen-Based Drug Delivery Systems for Tissue Engineering

The collagen scaffold with collagen binding BDNF enhances functional recovery by facilitating peripheral nerve infiltrating and ingrowth in canine complete spinal cord transection

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