The promotion of endothelial progenitor cells recruitment by nerve growth factors in tissue-engineered blood vessels

Zeng, Wen; Yuan, Wei; Li, Li; Mi, Jianhong; Xu, Shangcheng; Wen, Can; Zhou, Zhenhua; Xiong, Jiaqiang; Sun, Jun; Ying, Dajun; Yang, Mingcan; Li, Xiaosong; Zhu, Chuhong

doi:10.1016/j.biomaterials.2009.11.037

Cited by 45 publications

(30 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the results are conflicting due to the recruitment of other positive cells, which accelerate the formation of thrombus and the occurrence of inflammatory response . Secondly, cytokines, like nerve growth factor (NGF), stromal cell‐derived factor‐1

normalα

, brain‐derived neurotrophic factor, and VEGF are used to bind small‐diameter vascular grafts to recruit EPCs . Moreover, peptides such as TPS, RGD, and YIGSR were applied to cross‐link with small‐diameter vascular grafts to capture EPCs .…”

Section: Unipotent Stem Cellsmentioning

confidence: 99%

Cell‐based strategies for vascular regeneration

Zou

Fan

Fartash

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

Vascular regeneration is known to play an essential role in the repair of injured tissues mainly through accelerating the repair of vascular injury caused by vascular diseases, as well as the recovery of ischemic tissues. However, the clinical vascular regeneration is still challenging. Cell-based therapy is thought to be a promising strategy for vascular regeneration, since various cells have been identified to exert important influences on the process of vascular regeneration such as the enhanced endothelium formation on the surface of vascular grafts, and the induction of vessel-like network formation in the ischemic tissues. Here are a vast number of diverse cell-based strategies that have been extensively studied in vascular regeneration. These strategies can be further classified into three main categories, including cell transplantation, construction of tissue-engineered grafts, and surface modification of scaffolds. Cells used in these strategies mainly refer to terminally differentiated vascular cells, pluripotent stem cells, multipotent stem cells, and unipotent stem cells. The aim of this review is to summarize the reported research advances on the application of various cells for vascular regeneration, yielding insights into future clinical treatment for injured tissue/organ.

show abstract

normalα

Section: Unipotent Stem Cellsmentioning

confidence: 99%

Cell‐based strategies for vascular regeneration

Zou

Fan

Fartash

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Nerve growth factor (NGF) has also been found to promote EPC migration in vitro and mobilization and homing in vivo to a collagen-modified decellularized blood vessel matrix. 45 NGF was bound to the blood vessels, resulting in significantly increased endothelialization and patency rates in a mouse model. 45 Recently, brain-derived neurotrophic factor (BDNF) has been found to enhance graft patency rates in rats when bound to small-diameter tissue-engineered blood vessels.…”

Section: Growth Factor Incorporationmentioning

confidence: 99%

“…45 NGF was bound to the blood vessels, resulting in significantly increased endothelialization and patency rates in a mouse model. 45 Recently, brain-derived neurotrophic factor (BDNF) has been found to enhance graft patency rates in rats when bound to small-diameter tissue-engineered blood vessels. 46 BDNF was found to increase EPC mobilization and capture in vitro and in vivo.…”

Section: Growth Factor Incorporationmentioning

confidence: 99%

Strategies and Techniques to Enhance theIn SituEndothelialization of Small-Diameter Biodegradable Polymeric Vascular Grafts

Melchiorri

Hibino

Fisher

2013

Tissue Engineering Part B: Reviews

154

147

View full text Add to dashboard Cite

“…In a follow up study, it was proven that these cells were a CD34 (a hematopoietic progenitor) positive fraction of peripheral blood mononuclear cells (PBMCs),28 demonstrating that adult cPCs may participate in the process of endothelialization. Other studies have shown that cPCs may be responsible for in vivo endothelialization of stents,29, 30 synthetic scaffolds,17, 31, 32 and decellularized matrices33 (Table 2).…”

Section: Vascular Tissue Engineeringmentioning

confidence: 98%

Polymer‐based Scaffold Designs For In Situ Vascular Tissue Engineering: Controlling Recruitment and Differentiation Behavior of Endothelial Colony Forming Cells

Fioretta

Fledderus

Burakowska-Meise

et al. 2012

Macromolecular Bioscience

View full text Add to dashboard Cite

In situ vascular tissue engineering has been proposed as a promising approach to fulfill the need for small-diameter blood vessel substitutes. The approach comprises the use of a cell-free instructive scaffold to guide and control cell recruitment, differentiation, and tissue formation at the locus of implantation. Here we review the design parameters for such scaffolds, with special emphasis on differentiation of recruited ECFCs into the different lineages that constitute the vessel wall. Next to defining the target properties of the vessel, we concentrate on the target cell source, the ECFCs, and on the environmental control of the fate of these cells within the scaffold. The prospects of the approach are discussed in the light of current technical and biological hurdles.

show abstract

The promotion of endothelial progenitor cells recruitment by nerve growth factors in tissue-engineered blood vessels

Cited by 45 publications

References 36 publications

Cell‐based strategies for vascular regeneration

Cell‐based strategies for vascular regeneration

Strategies and Techniques to Enhance theIn SituEndothelialization of Small-Diameter Biodegradable Polymeric Vascular Grafts

Polymer‐based Scaffold Designs For In Situ Vascular Tissue Engineering: Controlling Recruitment and Differentiation Behavior of Endothelial Colony Forming Cells

Contact Info

Product

Resources

About