Strategies and Techniques to Enhance the<i>In Situ</i>Endothelialization of Small-Diameter Biodegradable Polymeric Vascular Grafts

Melchiorri, Anthony J.; Hibino, Narutoshi; Fisher, John P.

doi:10.1089/ten.teb.2012.0577

Cited by 153 publications

(151 citation statements)

References 161 publications

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“…Numerous attempts have been made to improve the patency and success of these grafts with inner diameters of <6 mm. 1,2 The reduced patency is generally caused by thrombosis and intimal hyperplasia, and the prevailing notion is that the early establishment of a healthy endothelium can reduce the risk of these issues. 3 One approach to expediting the growth of a functional endothelium is the seeding of cells on a vascular graft before implantation.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Endothelialization of Biodegradable Vascular Grafts Via Endothelial Progenitor Cell Seeding and Maturation in a Tubular Perfusion System Bioreactor

Melchiorri

Bracaglia

Kimerer

et al. 2016

Tissue Engineering Part C: Methods

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Section: Introductionmentioning

confidence: 99%

In Vitro Endothelialization of Biodegradable Vascular Grafts Via Endothelial Progenitor Cell Seeding and Maturation in a Tubular Perfusion System Bioreactor

Melchiorri

Bracaglia

Kimerer

et al. 2016

Tissue Engineering Part C: Methods

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“…Coating the lumen of synthetic vascular scaffolds with ECs has 62 been shown to prevent acute thrombosis [9]. Therefore, many 63 researchers have initially focused on the endothelialization of the 64 lumen of vascular scaffolds to produce an anti-thrombogenic 65 surface.…”

mentioning

confidence: 99%

Engineered small diameter vascular grafts by combining cell sheet engineering and electrospinning technology

et al. 2015

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“…[4,5]. Однако на сегодняшний день установ-лено, что несмотря на эффективность используе-мых материалов, необходима их модификация для ускорения образования эндотелиального слоя на внутренней поверхности сосудистого графта с це-лью предотвращения тромбообразования и гипер-трофии неоинтимы [6]. Ранее нами было показано, что одним из эффективных способов модификации биодеградируемого матрикса для привлечения эн-дотелиальных клеток является инкорпорирова-ние в его структуру сосудистого эндотелиального фактора роста (vascular endothelial growth factor, VEGF) [7].…”

Section: Abstract: Polycaprolactone Polyhydroxybutyrate/valerate Vunclassified

Biomechanical Remodeling of Biodegradable Small-Diameter Vascular Grafts in Situ

Глушкова

Sevost'yanova

Антонова

et al. 2016

RJTAO

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Aim: to evaluate the biomechanical remodeling of polymer grafts modified with vascular endothelial growth factor (VEGF) after implantation into rat abdominal aorta.Materials and methods. Vascular grafts of2 mmdiameter were fabricated by electrospinning from polycaprolactone (PCL) and a mixture of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) and PCL. The grafts were modified with VEGF by biphasic electrospinning. Morphology of the grafts was assessed by scanning electron microscopy. Physico-mechanical properties of PCL and PHBV/PCL grafts were estimated using uniaxial tensile test and physiological circulating system equipped with state-of-theart ultrasound vascular wall tracking system. Physico-mechanical testing of PCL/VEGF and PHBV/PCL/VEGF was performed before and after implantation into rat abdominal aorta for 6 months. The modeling of coronary artery bypass grafting (CABG) was performed by finite element analysis for modified grafts.Results. Durability of PCL and PHBV/PCL grafts did not differ from that of human internal mammary artery; however, elasticity and stiffness of these grafts were higher compared to internal mammary artery. Viscoelastic properties of the grafts were comparable to those of native blood vessels. Modification of the grafts with VEGF reduced material stiffness. Six months postimplantation, PCL/VEGF and PHBV/PCL/VEGF were integrated with aortic tissue that induced changes in the physico-mechanical properties of the grafts similar to the native vessel. Biomechanical modeling confirmed the functioning of modified grafts in bypass position for CABG.Conclusion. PCL/VEGF and PHBV/PCL/VEGF grafts have satisfactory physico-mechanical properties and can be potentially used in the reconstruction of blood vessels.

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Strategies and Techniques to Enhance theIn SituEndothelialization of Small-Diameter Biodegradable Polymeric Vascular Grafts

Cited by 153 publications

References 161 publications

In Vitro Endothelialization of Biodegradable Vascular Grafts Via Endothelial Progenitor Cell Seeding and Maturation in a Tubular Perfusion System Bioreactor

In Vitro Endothelialization of Biodegradable Vascular Grafts Via Endothelial Progenitor Cell Seeding and Maturation in a Tubular Perfusion System Bioreactor

Engineered small diameter vascular grafts by combining cell sheet engineering and electrospinning technology

Biomechanical Remodeling of Biodegradable Small-Diameter Vascular Grafts in Situ

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