The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer

Abstract

As water-soluble flavonoid derivatives, anthocyanidins and anthocyanins are the plants pigments mostly rich in berries, pomegranate, grapes, and dark color fruits. Many bioactivity properties of these advantageous phytochemicals have been reported; among them, their significant abilities in the suppression of tumor cells are of the promising therapeutic features, which have recently attracted great attention. The prostate malignancy, is considered the 2nd fatal and the most distributed cancer type in men worldwide. The present study was designated to gather the preclinical and clinical studies evaluating potencies of anthocyanidins/anthocyanins for the treatment and prevention of this cancer type for the first time. In general, findings confirm that the anthocyanins (especifically cyanidin-3-O-glucoside) indicated higher activity against prostatic neoplasms compared to their correlated anthocyanidins (e.g., delphinidin); in which potent anti-inflammatory, apoptosis, and anti-proliferative activities were analyzed. Complementary anti-prostate cancer assessment of diverse naturally occurred anthocyanidins/anthocyanins and their synthetically optimized derivatives through preclinical experiments and eventually confirmed by clinical trials can promisingly lead to discover natural-based chemotherapeutic drug options.

Combination Anticancer Therapies Using Selected Phytochemicals

“…Anthocyanins (ACN) are water-soluble flavonoids seen as pigments in the dark color of fruits and vegetables such as berries, pomegranates, berries, and rice [ 276 ]. They give different colors depending on their pH, they may appear red, purple, blue, or black.…”

Properties of flavonoids in the treatment of bladder cancer (Review)

“…Anthocyanins and anthocyanidins are plant pigments that account for various colors in plants and fruits. Anthocyanins are anthocyanidins structurally modified by sugar and acyl acids found mainly in dark fruits with excellent potential to inhibit tumor progression (145,146). The combination of anthocyanins, a bladder cancer preventive agent and mitomycin C has been reported to increase BLCA cell death (147).…”

Halochromic Behavior and Anticancer Effect of New Synthetic Anthocyanidins Complexed with β-Cyclodextrin Derivatives

“…Among a wide variety of natural compounds, anthocyanins and their derivatives were proved promising anticancer agents [ 9 ]. Mottaghipisheh et al [ 10 ] gathered many preclinical and clinical studies about the role of anthocyanins in cancer treatment. Sorrenti et al [ 11 ] confirmed that anthocyanins can induce apoptosis and suppression in prostate cancer cell proliferation.…”