The Promising Effect of Topiramate on Random-Pattern Skin Flap Survival in Rats

Ahmadzadeh, Mehdi; Esmaeilzadeh, Zeinab; Khezri, Mohammad Rafi; Jafari, Abbas Ali; Ghasemnejad‐Berenji, Morteza

doi:10.1007/s00266-022-02969-6

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…Oxidative stress induced by DOX plays an essential role in the pathogenesis of DOX-induced hepatic toxicity [26-28]. Prooxidants and antioxidants in normal biological systems are generally balanced [7,[29][30][31]. Both the accumulation of oxidants and the depletion of endogenous antioxidants can cause oxidative stress [32].…”

Section: Discussionmentioning

confidence: 99%

Protective effects of metformin against doxorubicin-induced hepatoxicity in rats

lal-Shahsavar,

Zolbanin,

Jafari

et al. 2023

Preprint

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Purpose Doxorubicin (DOX) is one of the most commonly prescribed anti-cancer drugs. However, DOX-induced hepatotoxicity is a dose-limiting side effect. This study aimed to clarify the potential protective effects of metformin on DOX-induced hepatotoxicity in rats. Methods The animals were divided into six groups (n=6 each): Control Group, DOX group, metformin 200 mg/kg group, DOX + metformin 50 mg/kg group, DOX + metformin 100 mg/kg group, and DOX + metformin 200 mg/kg group. Hepatic injury was induced by a single intraperitoneal injection of DOX (20mg/kg). The activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in serum were determined. Furthermore, the hepatic histopathological changes were evaluated. In order to identify the markers of oxidative stress, the level of malondialdehyde (MDA) and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver tissue were measured. Results Results showed that DOX provoked a marked elevation in ALT, AST, and ALP serum levels. In addition, oxidative stress was significantly boosted in DOX-treated rats compared to control rats. All these were abolished with the metformin administration. Histological examination also showed that metformin could significantly reduce DOX-induced alterations. The most prominent effect was observed by high-dose metformin. Conclusion This study showed that metformin could prevent doxorubicin-induced hepatoxicity.

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Section: Discussionmentioning

confidence: 99%

Protective effects of metformin against doxorubicin-induced hepatoxicity in rats

lal-Shahsavar,

Zolbanin,

Jafari

et al. 2023

Preprint

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Section: Methodsmentioning

confidence: 99%

“…Measurements were made with the ImageJ 1.52a software, and the percentage of necrosis area to total flap area was used for each individual to evaluate the skin flap survival rate between different groups. [26] 2.9 | Mechanical testing Ideally, surgical sutures should be physically pliable and comfortable to use, secure in knots, sterilizable, elastic enough, and have tensile strength against incision healing. Because of this reason, a microscale mechanical testing system of Zwick/Z10 was used to compare the ultimate tensile strength (UTS) of A. bruennichi dragline silk sutures, A.…”

Section: General Observations and Skin Flap Survival Evaluationmentioning

confidence: 99%

In vitro and in vivo investigation of Argiope bruennichi spider silk‐based novel biomaterial for medical use

Karahisar Turan,

Kılıç Süloğlu,

İde

et al. 2024

Biopolymers

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As a natural and biocompatible material with high strength and flexibility, spider silk is frequently used in biomedical studies. In this study, the availability of Argiope bruennichi spider silk as a surgical suture material was investigated. The effects of spider silk‐based and commercial sutures, with and without Aloe vera coating, on wound healing were evaluated by a rat dorsal skin flap model, postoperatively (7th and 14th days). Biochemical, hematological, histological, immunohistochemical, small angle x‐ray scattering (SAXS) analyses and mechanical tests were performed. A. bruennichi silk did not show any cytotoxic effect on the L929 cell line according to MTT and LDH assays, in vitro. The silk materials did not cause any allergic reaction, infection, or systemic effect in rats according to hematological and biochemical analyses. A. bruennichi spider silk group showed a similar healing response to commercial sutures. SAXS analysis showed that the 14th‐day applications of A. bruennichi spider silk and A. vera coated commercial suture groups have comparable structural results with control group. In conclusion, A. bruennichi spider silk is biocompatible in line with the parameters examined and shows a healing response similar to the commercial sutures commonly used in the skin.

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“…The increase in the absorbance at 420 nm was used to calculate the rate of pyrogallol autoxidation. An enzyme unit reduces pyrogallol autoxidation rate by 50% while SOD was measured in units/ min/g of protein (Ahmadzadeh et al, 2022).…”

Section: Sod Assaymentioning

confidence: 99%

Potential effects of noni (Morinda citrifolia L.) fruits extract against obsessive-compulsive disorder in marble burying and nestlet shredding behavior mice models

Jeyabalan

Bala

Kavimani³

et al. 2022

Front. Pharmacol.

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Obsessive-compulsive disorder (OCD) is a chronic and complex psychiatric disorder that usually includes both obsessions and compulsions. Morinda citrifolia L. (Noni) is a functional food and it is a well-known plant due to its potential therapeutic effects on human health in many disorders including neurological and neurodegenerative diseases. The purpose of this study was to evaluate the potential effect of M. citrifolia fruits extract (MCFE) against obsessive-compulsive disorder using the marble burying and nestlet shredding behavior mice models. In addition, brain neurotransmitters such as dopamine (DA), serotonin and noradrenaline (NA) were also assessed. Five mice were placed in each of the different groups, and the treatment was given to the animals for a period of 15 days. The marble burying test was evaluated for 30 min on days 1, 7, and 14 while the nestlet shredding test was evaluated for 60 min on days 2, 8, and 15. Treatments with MCFE (100 and 200 mg/kg, p.o.) significantly improved in both behavior tasks when compared to the control group. In addition, diazepam (2 mg/kg, i.p.) and fluoxetine (15 mg/kg,

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The Promising Effect of Topiramate on Random-Pattern Skin Flap Survival in Rats

Cited by 8 publications

References 44 publications

Protective effects of metformin against doxorubicin-induced hepatoxicity in rats

Protective effects of metformin against doxorubicin-induced hepatoxicity in rats

In vitro and in vivo investigation of Argiope bruennichi spider silk‐based novel biomaterial for medical use

Potential effects of noni (Morinda citrifolia L.) fruits extract against obsessive-compulsive disorder in marble burying and nestlet shredding behavior mice models

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